Trisquel being based upon Ubuntu does not mean a new Trisquel version starts
with the related Ubuntu ISO. It only means it starts with the related Ubuntu
repository. Ubuntu's default choices does not matter much (they only slightly
matter because those packages are likely to be more thoroughly tested).
As far as I can see on http://devel.trisquel.info/makeiso/iso/ the next
Trisquel 6.0 Toutatis will have a KDE edition (triskel) and an LXDE edition
(trisquel-mini) in addition to the GNOME version (trisquel).
I do not see the problem of running GNOME software on top of an LXDE or Xfce
desktop. All those desktops use the GTK toolkit: there is no real integration
issue.
Thanks to Fedora's work on running GNOME Shell with a software 3D
acceleration, there may not be any problem with this choice either.