*** For details on how to be removed from this list visit the *** *** CCP4 home page http://www.ccp4.ac.uk ***
1) is it even possible to observe any arbitrary, completely, truly disordered molecule (besides bulk solvent - vide infra) in the crystalline state with x-ray diffraction? i.e. can anyone cite a published crystal structure of totally disordered small molecules, or even intrinsically disordered proteins observed in the crystalline environment? (given that it can form _any_ lattice to begin with). 2) if so, what says the x, y, z, B, occupancy assumptions - that atoms are sufficiently ordered to begin with, if i understand - are even close to describing such a distribution? i.e. how would we know disordered molecules when we see them (or not)? 3) if a correction could be made, wouldn't such a correction be at least correlated with a bulk solvent correction, anisotropic scaling, or other treatments for diffuse scatter? -bryan
