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Bryan W. Lepore wrote:
1) is it even possible to observe any arbitrary, completely, truly disordered molecule (besides bulk solvent - vide infra) in the crystalline state with x-ray diffraction? i.e. can anyone cite a published crystal structure of totally disordered small molecules, or even intrinsically disordered proteins observed in the crystalline environment? (given that it can form _any_ lattice to begin with).
For example, would you be able to see density for the iron-mineral core of fully loaded ferritin? Would you need special "bulk solvent" parameters to refine it? EAB
