Aha, I shall quickly try with the non -w weighting and see what happens. 
Thanks! 
On 29 Apr 2013, at 15:05, Bruce Fischl <fis...@nmr.mgh.harvard.edu> wrote:

> yes, the -w will create an optimal weighting to maximize gray/white contrast. 
> The image it generates won't in general be physically realizable in an real 
> MR acquisition. Not surprising that the tal stuff fails
> On Mon, 29 Apr 2013, Fred Dick wrote:
> 
>> Hi Bruce
>> 
>> I'm using TR=20, flip=30, TE=5 - but possibly irrelevant as also have the -w 
>> flag on.
>> 
>> I originally thought this was from a bad brainmask, but then generated a 
>> good one and same thing happening.
>> 
>> 
>> On 29 Apr 2013, at 14:27, Bruce Fischl <fis...@nmr.mgh.harvard.edu> wrote:
>> 
>>> Hi Fred
>>> 
>>> we don't have much experience with this. Which synthesis are you using? You 
>>> might need to use a different one for the talairaching to more closely 
>>> match the atlas (maybe a TR=20,TE=2.5,flip=20-30 one)
>>> 
>>> 
>>> On Mon, 29 Apr 2013, Fred Dick wrote:
>>> 
>>>> Dear all
>>>> 
>>>> I'm having difficulties getting correct Talairach.lta's from synthetic 
>>>> flash volumes (Bruce, you are probably sorry you ever told me about 
>>>> this!).  Basically the brain is over-scaled (bigger than it should be), 
>>>> which I think is happening because the contrast is so good (gm much darker 
>>>> than wm).
>>>> 
>>>> Is there an example of how to use the -flash_parms flag, and what 
>>>> mri_em_register is expecting in the parameter file?
>>>> 
>>>> Thanks,
>>>> 
>>>> Fred
>>>> 
>>>> 
>>>> 
>>>> 
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>>>> 
>>> 
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>> 
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