Hi Dan,

No, mris_preproc and also surf2surf are functions that work on surfaces. You 
would just import the volume statistics into Matlab and fill the corresponding 
columns in your matrix directly, similar to using co-variates such as eTIV.

Best, Martin


On 1. Jul 2024, at 14:03, Dan Levitas <djlevitas...@gmail.com> wrote:

Hi Martin,

I wanted to ping this thread again, to confirm that my proposed mass-univariate 
workflow using the subcortical segmented ROIs is appropriate for the LME 
longitudinal analysis.

Thanks again.

Dan

On Thu, Jun 27, 2024 at 5:44 AM Dan Levitas 
<djlevitas...@gmail.com<mailto:djlevitas...@gmail.com>> wrote:
Hi Martin,

Thanks for your reply, it's good to know that the mass-univariate approach is 
still appropriate here.

Since the aseg segmentations are volumetric, can I still use the mris_preproc 
and mri_surf2surf functions? If so, would the mri_preproc function look 
something like mri_preproc --qdec-long /path/to/asegstats2table.long.table 
--target fsaverage --hemi rh --meas volume --out output_dir/rh.volume.mgh

If not, and I need separate functions, would mri_surf2surf be replaced by 
mri_vol2surf?




On Thu, Jun 27, 2024 at 4:51 AM Reuter, Martin,Ph.D. 
<mreu...@mgh.harvard.edu<mailto:mreu...@mgh.harvard.edu>> wrote:
Hi Dan,

You could do either one. I would recommend the mass univariate for multiple 
independent test with the same design.

Best, Martin

On 26. Jun 2024, at 17:20, Dan Levitas 
<djlevitas...@gmail.com<mailto:djlevitas...@gmail.com>> wrote:


I recently performed an LME longitudinal mass-univariate (surface) analysis and 
am now trying to do something similar, but with subcortical (aseg) ROIs instead.

I first created an aseg table with the following command:
 asegstats2table \
--sd $subjects_dir \
--qdec-long /path/to/long.qdec.table.dat \
--segno 4 10 11 12 17 18 26 43 49 50 51 53 54 58 251 253 255 \
--stats aseg.stats \
--tablefile $output_file


The LME tutorial 
(https://surfer.nmr.mgh.harvard.edu/fswiki/LinearMixedEffectsModels) provides 
information and examples of both a univariate and mass-univariate approach. 
While univariate seems most appropriate in this case, the example details 
design matrix setup and testing of a single ROI (hippocampus), whereas I would 
like to assess several subcortical ROIs.

Would I simply create a loop structure to set up design matrices for each ROI 
(both hemispheres) and test them individually, or can I perform a 
mass-univariate approach to assess all ROIs at once?

Thanks,

Dan


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