Hello NONMEM Users,
When clearance changes over time, the classic analytical solution for
the 2-compartment linear model is not correct. Nevertheless, if the
change is only ~30%, one can say it is still acceptable. Time required
to run an analytical and numerical models is drastically diff
Hello Chris,
What is the point of modeling 2 drugs in one NONMEM
code? Do the drugs interact? For example, you can have 2 monoclonal
antibodies competing for or binding to the same target and/or
concentration of
one drug changes elimination rate or some other parameters of th
You can add formulas to NONMEM code. All individual noncompartmental
parameters can be calculated within NONMEM. An example of the NONMEM
code is below. tH
DADT(6) = A(8) ;calculates AUC if A is concentration
DATD(8) = [put here the right part of the differential equation which
calc
Hello NONMEM Users,
When I tried to print log-scaled VPC, there was an error message about
negative
values. It can be caused by an additive error and/or linearization of
the
error model when NONMEM transforms
Y = F*DEXP(ERR(1)*SD1) into Y =
F+ F*ERR(1)*SD1. The error is inflated at
Hello The Team,
We hear different opinions about effectiveness of parallel processing
with NONMEM from very helpful to less helpful. It can be task
dependent. How useful is it in phase 3 for basic and covariate models,
as well as for bootstrapping?
We reached a non-exploratory (produc
Hello The NONMEM Team,
I removed $sigma record because ERR(1) and ERR(2) were not used
(home-made likelihood was used instead; SD was parameterized as THETA)
and got "A VALUE IN THE ESTIMATION RECORD IS INAPPROPRIATE" (see
below). The message sounds rather emotional than mathematical
("in
-
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web:www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel:(301) 767 5566
On 11/20/2015 5:15 PM, Pavel Belo wrote:
That is perfect!
P.
On Fri, Nov 20, 2015 at 04:04 PM, Bauer, Robert wrote:
Unfortunately adding records to est
be largely ignored in the
estimation step and not contribute much to run time.
Nick
On 21-Nov-15 08:59, Pavel Belo wrote:
Thank you Bill,
In my case it exactly doubles the number of records... The records
are daily measures and the code is running slow enough. I'll split
the code into es
expect that the MDV=1 records would be largely ignored in the
estimation step and not contribute much to run time.
Nick
On 21-Nov-15 08:59, Pavel Belo wrote:
Thank you Bill,
In my case it exactly doubles the number of records... The records
are daily measures and the code is running s
Hello The NONMEM Professionals,
The model requires SAEM. Is mu coding useful when each subject has to
have different SD (SDi=SD0*exp(etai))?
It may look something like
MU_8 =THETA(8)
SD = DEXP(MU_8 +ETA(8))
$THETA (0.1,0.0413,50) ;SD1
$THETA (0.001 FIX)
IPRED in the rows with MDV=1.
Thanks,
Bill
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Pavel Belo
Sent: Friday, November 20, 2015 11:47 AM
To: nmusers@globomaxnm.com
Subject: [NMusers] PRED for BLQ-like observations
Hello The NONMEM
Hello The NONMEM Users,
When we use M3-like approach, the outputs has PRED for non-missing
observations and something else for BLQ (is that PRED=CUMD?). As in the
diagnostic figures PRED for BLQs looks like noise, I remove them. It is
not always perfect, but OK in for most frequent cases.
>
@PD_value
+31 6 23118438
-- More value out of your data!
Op 06-11-15 om 17:05 schreef Pavel
Belo:
NONMEM demonstrated very large differences in
objective function when variability or correlations were added or
removed. Monolix demonstrated close-to-insignificant
matrix. Monolix teachers recommend to be
careful and try a diagonal matrix first.
Thanks,
Pavel
On Fri, Nov 06, 2015 at 08:42 AM, Pavel Belo wrote:
Hello Jeroen,
Thank you for your response. It was a practical question. I understand
the theory. What is the reason different
-value.com <http://pd-value.com>
jer...@pd-value.com <mailto:jer...@pd-value.com>
@PD_value
+31 6 23118438
-- More value out of your data!
On 11/04/2015 05:55 PM, Pavel Belo
wrote:
Hello NONMEM Users,
I try to make sense of the results and one of the ways
Dear Ashley,
What is the location of the position?
Kind regards,
Pavel Kovalenko
914-4622515
On Tue, Aug 11, 2015 at 11:30 AM, Ashley Weavers wrote:
Dear all,
Hope this email finds you well. Currently I have a senior level
Pharmacometrician position from a top, global pharmaceutic
Hello NONMEM Users,
I try to make sense of the results and one of the ways to do it is to
compare the same or similar models across software packages. 5x5 full
omega matrix is used because it was prohibitive to remove some
insignificant correlations from the matrix without removing significa
er-nmus...@globomaxnm.com> ] On Behalf Of Standing Joseph
(GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST)
Sent: Friday, September 26, 2014 09:15
To: Kowalski, Ken; 'Eleveld, DJ'; 'Pavel Belo'; nmusers@globomaxnm.com
<mailto:nmusers@globomaxnm.com>
Su
h
(GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST)
Sent: Friday, September 26, 2014 09:15
To: Kowalski, Ken; 'Eleveld, DJ'; 'Pavel Belo'; nmusers@globomaxnm.com
<mailto:nmusers@globomaxnm.com>
Subject: RE: [NMusers] OMEGA matrix
Dear Pavel,
To answer your
Hello Nonmem Community,
It seems like NONMEM developers may advise to start with full OMEGA
matrix at the beginning of model development. Monolix developers may
advise to start with a diagonal matrix. Is there something different
in NONMEM SAEM algorithms that makes model stable when a
ivariate normal, but
then use a 1-d pseudo-random sequence to generate the chi-square random
variable.
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Emmanuel Chigutsa
Sent: Thursday, May 15, 2014 1:03 PM
To: Pavel Belo; nmusers@globomaxnm.com
Sub
Hello NONMEM Users,
As SAEM does not provide a useful objective function, the manuals
recommend using IMP after SAEM. It works well in many cases when IMP
works well. When IMP works well, SAEM is not always needed. SAEM is
really needed when the other methods do not work well.
The issue i
to the error message.
Can you send me your complete control stream?
On Wed, Mar 26, 2014, at 05:23 PM, Pavel Belo wrote:
Thank you Nick.
It does not work. The error message is the same. It is strange. It
almost looks like a bag or an installation issue. I tried it on
gical test is required
HM=1
ELSE
HM=0
ENDIF
ENDIF
On 27/03/2014 11:23 a.m., Pavel Belo wrote:
Hello NONMEM73 Users,
I try to use call random:
$PK
IF (ICALL.EQ.4.AND.NEWIND.NE.2) CALL RANDOM(2,R)
IF (ICALL.EQ.4.AND.R.LE.0.1855) HM=1
IF (ICALL.EQ.4.AND.R.GT.0.1855)
Hello NONMEM73 Users,
I try to use call random:
$PK
IF (ICALL.EQ.4.AND.NEWIND.NE.2) CALL RANDOM(2,R)
IF (ICALL.EQ.4.AND.R.LE.0.1855) HM=1
IF (ICALL.EQ.4.AND.R.GT.0.1855) HM=0
It does not matter how I try to code it, I am receiving the same error
message:
372 "R" IN CA
=K0*A(2)-K0*A(3)
...
DADT(X)=K0*A(X-1)-K0*A(X)
AUCapprox=A(2)+...+A(X)
This will prolong the shape of AUCapprox(t). It could be a bit simpler
and smoother than tlag implementation Leonid
Original email:
-
From: Pavel Belo non...@optonline.net
Date: Thu, 16 Jan 2014 13:
r than tlag implementation
Leonid
Original email:
-
From: Pavel Belo non...@optonline.net <mailto:non...@optonline.net>
Date: Thu, 16 Jan 2014 13:05:54 -0500 (EST)
To: lgibian...@quantpharm.com <mailto:lgibian...@quantpharm.com> ,
nmusers@globomaxnm.c
Leonid
Original email:
-----
From: Pavel Belo non...@optonline.net
Date: Tue, 14 Jan 2014 13:45:18 -0500 (EST)
To: robert.ba...@iconplc.com, nmusers@globomaxnm.com
Subject: [NMusers] backward integration from t-a to t
Dear Robert,
Â
Efficacy is frequently considered a function of AUC. (A
t start of
treatment)
Are you aware of the standard models for effect delay that one would
commonly consider and why did you dismiss these?
Best regards
Jakob
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Pavel Belo
Sent: 14 January 2014 18:45
Sr. Statistical Programmer\Statistical Programmer I\II
Job Location: Tarrytown, NY
Auto req ID: 1208BR
Job Posting Title: Sr. Statistical Programmer/Statistical Programmer
I/II
Person Type: Regular
Posting Category: Research & Discovery
Location: Tarrytown
Job Summary and Essential Functi
you aware of the standard models for effect delay that one would
commonly consider and why did you dismiss these?
Best regards
Jakob
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Pavel Belo
Sent: 14 January 2014 18:45
To: Bauer, Robert
C
Please never mind. Someone suggested tose tlag, which is a simple
and efficient enough way to do it.
Regards,
Pavel
Dear Robert,
Efficacy is frequently considered a function of AUC. (AUC is just an
integral. It is obvious how to calculate AUC any software whic
Dear Robert,
Efficacy is frequently considered a function of AUC. (AUC is just an
integral. It is obvious how to calculate AUC any software which can
solve ODE.) A disadvantage of this model of efficacy is that the effect
is irreversable because AUC of concentration can only increa
Hello Kajsa,
Do you have an example of PsN configuration file for NONMEM7.3/windows?
Whan I try to install PsN, it asks me for NONMEM directory for the
psn.config file. When I provide it, PsN states it cannot find the nmfe
file in run or other directories.
Pavel
On Wed, Dec 04, 2013 at 09:
Hello
Nele,
You can try Ke, V2, K23 and K32 instead of Cl, Q, V2 and V3. It
may mostly remove the correlation between V2 and Cl because
Cl=V2*Ke. If F1 is not a parameter in your model and you give
SC doses, it is the same. You have (Cl/F1) = (V2/F1)*Ke, i.e.
your parameters are "app
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