for those who may be interested.  

--- "Jonathan B. Britten" wrote:
> List,
> 
> Many members know about big Pharm fraud, but few
> examples are as 
> compelling at the L-Tryptophan scam, which I recall
> very, very well.   
> BROJON, although being rather uneven in my opinion,
> has a great piece 
> which I am pasting below.
>             THE INSIDER'S STORY OF AN  L-TRYPTOPHAN
> RESEARCHER
>                                   A Response To
> Reader's Requests
> 
> I have received a number of letters to the editor
> asking about which 
> L-tryptophan is the best and where to buy it.  Many
> readers want to 
> start using it each morning to maintain their
> circadian rhythms.  For 
> almost 20 years it has been impossible to purchase
> L-tryptophan.  So 
> where did I buy my tryptophan for my research for
> the last 20 years?
> 
> During the 1980's when I started my circadian rhythm
> experiments, I 
> used the common L-tryptophan found in stores.  I
> soon found there were 
> two types --one with B6 and one without any B6.  I
> tried several brands 
> of each and found that the ones with B6 did not work
> at all in my 
> experiments for shifting or controlling the
> circadian rhythms.  Thus 
> proving that B6 prevents tryptophan from getting
> into the brain.  Using 
> B6 will definitely disrupt your normal circadian
> rhythms.
> 
> I later found that almost all the L-tryptophan in
> all brands was made 
> from the same bulk raw product from Japan.  The
> Showa Denko company had 
> developed a method of using genetically modified
> bacteria to extract 
> copious amounts of L-tryptophan from milk.  Since
> the bacteria was 
> removed and reused, what remained was pure, cheap
> L-tryptophan.  It is 
> now the same method used for making all the other
> amino acid products.
> 
> In November 1989, the CDC made the false claim that
> L-tryptophan was 
> causing a new disease or disorder called
> Eosinophilia Myagia Syndrome 
> (EMS).   The symptoms of EMS were exactly the same
> as trichinosis.  
> Trichinosis is a parasite which comes from eating
> improperly cooked 
> pork.  My research found that about half of all
> American's have 
> contracted the trichinosis parasite.  But for most
> people it is 
> sub-clinical, meaning most people don't even know
> that they have 
> trichinosis.  This sub-clinical form of the disease
> is the primary 
> reason for most autoimmune disorders such as
> fibromyagia and chronic 
> fatique syndrome.  The body immune system attacks
> itself in an attempt 
> to get rid of the parasite.  The disease is caused
> by microscopic worms 
> embedding by the millions into your muscles.  Then
> they form a tiny 
> impenetrable cyst which protects them from
> medication and from your own 
> immune system.  No effective medication has been
> found for ridding the 
> body of trichinosis.
> 
> For most people the original symptoms were a slight
> fever like the flu, 
> and achy muscles as the trichinella enter the
> muscles and become 
> encysted.   It takes about a week and later those
> early symptoms go 
> away and are forgotten.  Those were exactly the same
> symptoms which 
> were identified as EMS by the CDC.   In the first
> week after the CDC 
> alert for EMS, the doctors before reporting EMS
> needed to perform a 
> trichinosis test.   In the second week after the CDC
> alert, the 
> trichinosis test requirement was strangely dropped,
> so all the usual 
> hundreds of thousands of cases of trichinosis were
> then falsely 
> reported to the CDC as the new tryptophan disorder,
> EMS.
> 
> The CDC also changed the reporting requirement to
> include: observe the 
> symptoms and also, secondly interview the patient
> for having previously 
> or still using L-tryptophan.   Thus, suddenly this
> became an 
> L-tryptophan disease.  But it wasn't at all.  It was
> just the common 
> trichinosis.  I was using L-tryptophan in my
> research studies but I 
> never had any symptoms.  Something was very wrong
> with the CDC story 
> about EMS and the ban on sales of L-tryptophan.
> 
> I suspected then that this was a fraudulent story
> and I have kept in my 
> files, several years worth of all the CDC reports
> and university 
> research reports into the suspected causes for EMS. 
> The CDC even 
> blamed Showa Denko for making a contaminated product
> and forced them 
> out of business.  But NO cause of EMS was ever found
> and the story was 
> quietly dropped, but the ban for local drug stores
> to sell L-tryptophan 
> has remained.  Mysteriously and quietly the ban on
> sales has been 
> dropped in the last year and now many small sellers
> are using the 
> Internet to push L-tryptophan.  Why?  What has
> suddenly changed?
> 
> The original reason for banning the sale of
> L-tryptophan is still a 
> mystery.  I suspected the illegal ban was bought and
> paid for by Eli 
> Lilly which made nearly a trillion dollars by
> selling Prozac, which was 
> designed to replace L-tryptophan as a means to raise
> the level of 
> serotonin in the brain.  Of course the reason for
> the "brain chemical 
> imbalance" or low level of serotonin in the first
> place was the 
> over-abundance of B6 in the diet which eliminates
> L-tryptophan from the 
> body.  That strange relationship is why I have
> studied and done 
> experiments with both L-tryptophan and B6 for the
> last 20 years.
> 
> Right after the sales ban in November 1989, I looked
> for alternate 
> sources for L-tryptophan.   I did find a source, a
> company called BIOS 
> Biochemical, which was continuing to sell
> L-tryptophan, not for people, 
> but to farmers who added the product to cattle feed.
>  Since about 10 
> percent of the protein in cow's or mother's milk is
> tryptophan, by 
> adding L-T to the dairy feed, the farmers could
> increase the milk 
> output from their cows.  Adding $5 worth of
> tryptophan to the dairy 
> feed would increase the milk output by about $500
> over the life of the 
> dairy cow.  Such a deal for the farmer on such a
> small investment.
> 
> The BIOS Biochemical product was also USP quality so
> it was certified 
> for purity and content -- even though the product
> was clearly marked 
> "For Veterinary Use Only."  Just ignore that.  That
> was to get around 
> the CDC ban.  L-tryptophan from cows milk or
> mother's milk is exactly 
> the same.  If the CDC wanted to completely ban
> L-tryptophan they would 
> have needed to outlaw breast feeding.  And that's
> never going to 
> happen.  Also L-tryptophan, when it was packaged
> with other amino acids 
> and vitamins such as B6 was never banned for sale. 
> Is that mysterious 
> or what?
> 
> At that time, BIOS was the only source I found for
> tryptophan and it 
> was online in 1990, which was just a few years
> before the Internet.  In 
> those days, to be online meant you had an account
> with Compuserve, AOL 
> or smaller sites such as Mindspring.  AOL actually
> let you create your 
> own “homepage” or “webpage” which since than has
> grown from several 
> hundreds of pages to multiple billions of websites. 
> I have been using 
> BIOS Biochemicals for 16 years.  For cattle feed,
> the company sells 
> L-tryptophan in large bags or bulk containers by the
> multiple pound.  
> They also sell the powder in 500mg capsules.  I had
> been using 250 to 
> 500mg capsules before 1989.  I figured that the
> cattle farmers are not 
> stuffing capsules in the mouths of their cattle, so
> the only purpose of 
> the capsules must be for human use.
> 
> Thus, BIOS must have known that their biggest L-T
> market was tryptophan 
> for  humans who did not believe the CDC's EMS hoax
> story.  Prior to the 
> CDC ban, about 30 million Americans had been using
> L-tryptophan for a 
> variety of problems, mostly circadian rhythm
> disorders. Most of these 
> people were later diagnosed as "brain chemical
> disorder" and were put 
> on Eli Lilly's Prozac.  Thus Lilly already had a
> huge ready-made market 
> for their Prozac.  But instead of a 20-cent
> L-tryptophan capsule each 
> day, the people were paying $20 or more per day for
> Prozac -- which 
> supposedly did the same thing.
> 
> Since BIOS has also sold its L-T in large bags since
> before the 1980's, 
> I assume that most of all the other small marketers
> who now sell 
> L-tryptophan online are simply buying the big bulk
> bags from BIOS and 
> then repackaging it into small capsules.  Since it
> costs a lot of money 
> to get a product USP certified, it seems only
> natural that all the 
> smaller tryptophan companies now selling on the
> Internet are getting 
> their USP certified product simply by buying the raw
> product in bulk 
> from BIOS.  What that means is that it doesn't
> matter which brand or 
> source you use for USP L-tryptophan  -- because they
> are all the same 
> -- they all come in bulk from BIOS Biochemicals.
> 
> If you search on Google for buying L-tryptophan you
> will get many pages 
> for marketers of USP L-tryptophan.  Way down on the
> 4th or 5th page you 
> find BIOS.  The reason is because BIOS doesn't need
> to advertise their 
> product.  They ARE the source, and everybody else is
> selling their 
> product.  BIOS doesn't need to compete with its own
> distributers.
> 
> Based on that information, I have been buying
> directly from the source 
> for the last 16 years.  If you find something better
> let me know.   I 
> don't work for BIOS, so I am not selling or
> promoting their product.  I 
> just use it.
> 
> And what about the strange mystery of why it has
> suddenly become so 
> easy to buy L-tryptophan?  Maybe it is just strange
> coincidence (I 
> don't believe in strange coincidences), but two
> years ago the Eli Lilly 
> international drug patent ran out.  Numerous other
> pharmaceutical 
> companies are now making generic Prozac, not for $20
> per dose, but for 
> about a dollar a dose.  So Prozac is no longer a big
> profit item.  The 
> Prozac era has come to an end.  There is no longer a
> need to eliminate 
> the competition from 50 cent L-tryptophan.  Since
> nobody is now pushing 
> for a ban on L-tryptophan to keep competitors off
> the market, it has 
> suddenly become very easy to purchase it, but still
> it is not being 
> stocked in stores.  So buying online is still the
> best bet.  But that 
> does explain the mysterious and sudden easing of the
> ban on 
> L-tryptophan.  Could the 19-year ban on the sales of
> L-tryptophan be 
> called a huge billion dollar Big Pharma fraud?   You
> betcha.  And 
> similar such frauds are continuing today.
> 
> But if you doctor is still suggesting you use Prozac
> or Zoloft or any 
> of the other similar SSRI's consider this.  If you
> take L-tryptophan in 
> the morning it produces serotonin in the brain, and
> raises the brain 
> temperature and wakes you up.  If you take
> L-tryptophan in the evening 
> it produces melatonin in the brain, which lowers the
> brain temperature 
> and induces sleep.  This operates the daily cycle of
> your circadian 
> rhythms.
> 
> If, instead, you take Prozac in the morning, it
> raises your brain 
> temperature, and works something like an
> anti-depressant.  But if you 
> take Prozac with an evening meal, as prescribed by
> some doctors, it 
> will still raise your brain temperature and keep you
> awake all night 
> long.  One of the most common reported side-effects
> of Prozac or the 
> other SSRI's is insomnia or circadian rhythm
> disorders.  It only works 
> as an anti-depressant if you take it first thing in
> the morning.  But 
> if instead, you take L-tryptophan at any time of
> day, it automatically 
> converts to serotonin or melatonin depending on the
> time of day when 
> you take it.  It works automatically to run your
> circadian rhythms, you 
> can't overdose and there are no side-effects such as
> insomnia.  But for 
> “Tryptophan Pumping” is still works best if you take
> it first thing in 
> the morning.  That's how you get optimum and
> quickest results.
> 
> If you want to do your own circadian rhythm
> experiments, go here:
> BIOS Biochemicals
> www.biochemicals.com
> 
> If you find this information is valuable, post a
> copy of this to the 
> Internet and let everyone know about it.  Also tell
> your friends that 
> they can sign up for the BroJon Digest to get the
> latest research about 
> circadian rhythms, as it is published.  Or go to the
> BroJon Gazette to 
> read all the stories in the “B6 Bomber” series.
> 
>      Marshall Smith
>      Editor, Brother Jonathan Gazette
>      newsedi...@brojon.com
> 
> Click here to find the live links to the full
> stories in the Gazette -
>      http://www.brojon.com
> 
> 
> KBB


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