At 08:49 PM 3/6/2010, you wrote:
Sol,
Perhaps my message didn't come through with the a response to your
question of my dogs color of fur or skin color noticeable changes or
it was missed. So here's the answer:
skin color on paws and legs only changed--not fur.
Thanks, that was not clear to me at all, so I am happy to have you
clarify it in terms I can understand.
Believe it or not, this is my story and our eyes including the VET
seeing it too which I just remember asking him about.
I don't exactly recall how many days or weeks, at this point as I
didn't chart it, but my posts you may be able to track for more
exact details before it became noticeable. It may have just
happened....I don't have scientific proof to back up my sayings
other than my eyes and others who saw dog.
My point is that I have never ever seen such a skin color change
posted about in any other animal, and though it may be inaccurate to
generalize from human cases of argryia to an animal, but in a human
argryia (so far as I know to date) does not develop in one month, nor
does it reverse in weeks after stopping CS. You may have followed the
thread on those here who have argryia from YEARS of high dose CS. I
have blue moons, that appeared after about 2.5 years of very high
dose CS daily. It is now about 5 years since I acquired the color in
my nails, and during those 5 years I have not taken CS daily and not
ever in constant high doses, and the color has not left, and hasn't
even faded much.
I just don't see how CS could cause what you saw in your dog (I do
not say you didn't see it, obviously you did) and I have seen NO
similar reports at all in an animal or a human. CS takes a long time
to build up to causing skin color changes, and a long time to reverse
the color change if it can EVER be reversed, which is debatable, and
may be different for different individuals.
I hope my question may bring up some ideas and different input. Maybe
someone else has seen something similar in an animal and just never
posted about it. If so, it will be interesting to see ideas on how CS
could work so very differently in an animal than in humans in this
one instance, since in all other instances I am aware of, mechanisms
of action of CS are virtually the same in all mammals, and even in birds.
It is human and normal to see something happen and attribute it to
the new and unfamiliar thing that has been added to a treatment
regimen. That doesn't mean such a conclusion is correct. To be
perfectly honest, if you were not new to CS, and had had years of
experience with it, I believe you might have looked for another
cause. It may yet turn out you are right and it was the CS, but
someone needs to give me a good rational mechanism for how CS could
have done it and it reversed so quickly, given what we think we know
about how CS works, and how it accumulates in body tissues to date.
Without that, I cannot believe you have the right cause.
sol
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