C. Creel, 

The abstract you posted is remarkable.  Could you possibly post more
about that?  I am very curious to know how this woman ingested so much
silver as to develop argyria, and to know why such an extensive autopsy
was conducted.   The whole story would be tremendously useful to members
on this list;  if you buy the MedLine report it would be a great
service.   Few postings on this list have been as relevant as this one,
in my opinion.   



C Creel wrote:
> 
> Dear Solar,
> 
>   You said:
> 
> <<My whole point was.... Read carefully, and don't jump to make
> outlandish statements.>>
> 
>      Someone asked for studies, I sent some abstracts.  I made no statement
> about them. I would never presume to draw any conclusions from abstracts.
> Trust me, I know how to pick apart a study.  I can do it with
> the best of them.  It sometimes gets me in trouble around here ;-)
> 
>   I did respond to another post with some speculative ideas and questions.
> Heck, I didn't even get to the point of forming a hypothesis.
> 
>    I'm in complete agreement with your point,  but I'd like to  also make a
> point.
> One cannot expect to find literature on the toxicity of silver to the brain
> when silver itself supposedly doesn't cross the BBB.   Could it be that what
> is being suggested is that CS does not cross the BBB?   There appears to be
> some evidence that silver
> can possibly affect the brain:
> 
> Brain involvement in generalized argyria.
> 
> Clin Neuropathol, 3: 1, 1984 Jan-Feb, 32-6
> 
> Abstract
> Cutaneous argyria was diagnosed in a 59-year-old woman. Manic depressive
> psychosis developed at about the same or a short time thereafter. The
> patient died 6 years later from a ruptured aortic aneurysm. At autopsy
> silver deposits were seen in skin, mucous membranes, heart, kidney, and
> liver. In the central nervous system the leptomeninges and choroid plexuses
> contained silver granules. In addition, silver granules were visualized in
> the walls of many intraparenchymal vessels, particularly of the basal
> ganglia, hypothalamus, substantia nigra, and cerebellum. Progressive glial
> changes and cellular gliosis were evident in many areas of the brain. With
> the electron microscope the deposition of silver granules in basal membrane
> structures of the choroid plexus and intracerebral vasculature was amply
> confirmed. Furthermore, silver deposition was seen in brain parenchymal
> cells inside bodies of apparently lysosomal nature. The silver content of
> various brain regions was determined by absorption spectrophotometry.
> 
> Dietl HW; Anzil AP; Mehraein P
> 
>   **  I'm not arguing a position.  I will have no position until I have
> what I consider to be enough information.  Brooks provides some
> good information.  I wish it was published in full, even if only
> on a website.
> 
> Regards,
> Catherine
> 
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