As I was writing the message below describing how Cystic Fibrosis patients take A LOT of supplements, minerals, and so on I realised I'm not quite sure about.. Are there any foods, drinks, etc. that decrease the effectiveness of the CS? Some interactions?? Thanks,
Maia --- Maja Hristozova <majahristoz...@yahoo.com> wrote: > Hello Duncan > Yes, selenium is well known and taken by most Cystic > Fibrosis people that I know. They also take > additional > antioxidants, almost all vitamins (C + all the fat > solable), Calcium, Magnesium (which play a major > role > in many processes in the body), DHA, CoEnzymeQ10 and > some antioxidant herbs and essential oils. The list > of > daily supplements is really long. > As for the GSH - taking it orally is not.. clear. I > mean there are pros and cons, something to do with > the > fact that when taken orally it doesn't go into the > cells but stays outside (which for some reason is > not > good for CF). There are CF people that use it orally > with success, but others are sceptical. Not many > papers on that. There is a group of researchers > though > that investigated GSH inhalations. This is 'on the > age' research, very new, not established but so far > successful. > > As someone pointed though all these things do not > change the genetical disorder - the CFTR channel is > still staffed up and so far there is no cure for > that. > > > And there are other issues - mixing and interaction > between all these supplements. The more they become > the more you get confused what causes what. You get > bounded by all the timing and dossages ... > Just recently MannaRelief started a study on the > effect of their products (mainly Aloe Vera based) on > CF patients. So now some take these gluconutriens as > well. > > I'll update later today how is Kamellia going with > the > Colloidal Silver. > > Maia > > --- Duncan Crow <duncanc...@shaw.ca> wrote: > > Did the cystic fibrosis treatement program address > > the control of > > oxidative stress? I ask because there are > hundreds > > of articles pointing > > out the culprit in lung disorders as being chronic > > oxidative stress > > (lipid peroxidation). This can be stopped cold > with > > cold-processed whey > > and selenium, and an antioxidant program. > > > http://members.shaw.ca/duncancrow/medline_links.html > > Here's just one study chosen at random so you'll > see > > what I mean. > > > > The mucus and inflammation and most of the scar > > tissue is produced by > > irritation from whatever sourse and propagated by > > free radical damage. > > Glutathione increase (requires selenium) stops all > > that and also reduces > > the Th2 inflammatory cell count on favour of > > non-inflammatory, reduced > > damage, Th1. But since all the antioxidants work > > together I recommend a > > program of them to my clients. > > > > __________________________ > > Monaldi Arch Chest Dis 2002 Jun-Aug;57(3-4):173-6 > > Related Articles, Links > > > > Role of oxidative stress in pulmonary fibrosis. > > > > Mastruzzo C, Crimi N, Vancheri C. > > > > Dipartimento di Medicina Interna e Medicina > > Specialistica, Sezione di > > Malattie Respiratorie, Universita di Catania, via > > Passo Gravina 187, I- > > 95125 Catania, Italy. > > > > Pulmonary fibrosis can be observed as an end state > > in a number of chronic > > inflammatory pulmonary diseases. Although the > > mechanisms by which lung > > fibrosis develops are not fully ascertained, > recent > > findings suggest that > > oxidative stress may play an important role in the > > pathogenesis of tissue > > fibrosis affecting apoptosis of both structural > and > > inflammatory cells > > and altering the cytokine microenvironment > balance. > > Damage and alteration > > of alveolar epithelial cells is one of the > hallmarks > > of interstitial lung > > fibrosis. Recently, it has been demonstrated that > > the presence of > > oxidative stress may lead to the damage, > activation > > and/or apoptosis of > > alveolar epithelial cells either directly, through > > an imbalanced > > intracellular redox equilibrium, or indirectly, by > > activating redox- > > sensitive effector pathways, such as transcription > > factors and > > angiotensin converting enzyme, increasing the > > conversion of > > angiotensinogen into angiotensin II that can be > > considered a mediator of > > oxidative stress, capable of inducing apoptosis. > > Furthermore, it has been > > demonstrated that angiotensin II acts as a > > proinflammatory cytokine and > > is effective in activating fibroblasts through the > > release of > > transforming growth factor (TGF-beta). As well as > > activation, > > differentiation, proliferation and apoptosis of > > fibroblasts seem related > > to the oxidant/antioxidant balance, and the > > maintenance of a high > > intracellular level of reduced glutathione (GSH) > is > > considered crucial in > > providing a reducing environment within the cell, > > able to protect against > > oxidative stress. In those conditions where > > oxidants, either inhaled or > > produced by inflammatory cell, increase, the ratio > > between GSH and > > oxidized glutathione (GSSH) may lower, influencing > a > > variety of cellular > > redox-sensitive signaling processes such as the > > activation of nuclear > > factor-kB (NF-kB) and activator protein-1 (AP-1) > > that lead to a > > transcriptional up-regulation of a number of genes > > involved in > > inflammation and/or fibrogenesis, including > > cytokines [interleukin (IL)- > > 1,, tumor necrosis factor (TNF-alpha), IL-6] > > chemokines (IL-8), adhesion > > molecules (VCAM-1, ICAM-1) and growth factors > > (GM-CSF). In addition, > > several studies have shown that oxidative stress > may > > also affect the > > immune response by inducing an up-regulation of > > HLA-DR as well as the > > expression of two costimulatory molecules such as > > CD40 and CD86, > > determining a persistent state of immune > activation, > > and affecting the > > Th1/Th2 balance, modulating the T-cell effector > > response towards the Th2 > > phenotype. It is clear that a better understanding > > of the precise > > sequence of events that make the difference > between > > normal tissue repair > > and fibrosis, including the role played by > oxidative > > stress, will > > certainly improve our therapeutic approach to > > pulmonary fibrosis. > > ___________________________ > > > You would be surprised.... Cystic Fibrosis > people > > have > > > tried many things... > > > One mother tried DMSO on the sputum of her > Cystic > > > Fibrosis son. It tickens the mucus though and > she > > > never tried using with on the son. Tick mucus is > > > killing for them. I assume it's because their > > mucus > > > has a different structure. They have much more > > salt in > > > the sweat, etc. > > > > > > -- > > The silver-list is a moderated forum for > discussion > === message truncated === __________________________________________________ Do you Yahoo!? Yahoo! Tax Center - File online, calculators, forms, and more http://tax.yahoo.com -- The silver-list is a moderated forum for discussion of colloidal silver. Instructions for unsubscribing may be found at: http://silverlist.org To post, address your message to: silver-list@eskimo.com Silver-list archive: http://escribe.com/health/thesilverlist/index.html List maintainer: Mike Devour <mdev...@eskimo.com>
