Hi Joyce. 
It looks like your liver counts are 1-10% common to increase on that drug.  
Read the information that comes with the meds.   Read the whole document 
through. 
They will stabilize as well as other side effects.  
It seems I will go from one side effect to another as time passes. 
Fight on.  Good luck. 

My Motto: Faith and Pills
Jeanie 🐟🐟18,s 
Dx 1/2004. CML Leukemia
Started Gleevec 2/2004
Started Tasigna  9/2009
Started Sprycel 11/2009
Started Ponatinib January 2015
Dr Balducci Moffitt Cancer Center

> On Jul 23, 2015, at 11:43 PM, Joyce Mesnarich <joy...@htc.net> wrote:
> 
> Jeanie,
> Thanks for your interest and suggestion.  We have gone over all his other 
> meds with doctors and nothing should affect the liver.  He doesn't take any 
> OVC pain meds, or any pain meds.  And he does not drink alcohol.  The primary 
> doctor says that the drug information for bosulif says it can cause liver 
> problems, but Dr Talpaz is less certain of that and he is the specialist.  He 
> says he is watching it closely and I guess we will just trust him.  Wayne is 
> getting blood tests every other week locally and they are sent to Dr Talpaz.  
> The liver enzyme levels seem to have stabilized, although they are elevated.  
> As you say, faith and pills.  One of Wayne's mottos is "Better living through 
> chemistry".  LOL  I think that used to be part of a TV ad for a large 
> chemical company, maybe Du Pont or Monsanto.
> 
>               Joyce in IL
> 
> 
>> On Jul 23, 2015, at 11:32 AM, 'Icandoallttc' via CMLHope wrote:
>> 
>> Be careful with his diet.  Ovc pain pills hurt the liver as well as other 
>> drugs we take.  Ask your pharmacy if any other drugs he take are hurting his 
>> liver.  It's hard but maybe they can figure out something. 
>> Good luck. 
>> 
>> My Motto: Faith and Pills
>> Jeanie 🐟🐟18,s 
>> Dx 1/2004. CML Leukemia
>> Started Gleevec 2/2004
>> Started Tasigna  9/2009
>> Started Sprycel 11/2009
>> Started Ponatinib January 2015
>> Dr Balducci Moffitt Cancer Center
>> 
>>> On Jul 22, 2015, at 2:01 PM, lrc lrc <kneesrb...@gmail.com> wrote:
>>> 
>>> Joyce does he drink alcohol?
>>> 
>>>> On Jul 22, 2015 1:43 PM, "margood18 via CMLHope" 
>>>> <cmlhope@googlegroups.com> wrote:
>>>> Joyce, so glad to hear that your husband's PCR is lower and I hope that 
>>>> his liver function will steady.  Best wishes to both of you.
>>>> 
>>>> Marcie
>>>> 
>>>> 
>>>> -----Original Message-----
>>>> From: Joyce Mesnarich <joy...@htc.net>
>>>> To: cmlhope <cmlhope@googlegroups.com>
>>>> Sent: Wed, Jul 22, 2015 12:16 pm
>>>> Subject: [CMLHope] New results
>>>> 
>>>> Hello everyone.  I have not had time to contribute for awhile.  But I must 
>>>> let
>>>> you all know the results of my husband's PCR at his last visit to Dr 
>>>> Talpaz.  He
>>>> was taken off Sprycel due to pleural effusion and we were hoping his
>>>> undetectable would hold....but it did not.  He was subsequently put on 
>>>> bosulif
>>>> and not showing much improvement after 3 months.  So his dosage was 
>>>> changed from
>>>> 100 mg to 200 mg.  And now, after 3 more months, his PCR went from 8.7 to
>>>> 0.127!!  Hopefully in another 3 months he will once again reach
>>>> undetectable.
>>>> 
>>>> The downside of his test results is that the liver function
>>>> tests have increased a lot.  The doctor will not really say that bosulif 
>>>> is to
>>>> blame, but nothing else has changed.  Has anyone of you CML warriors had 
>>>> any
>>>> problems with the liver while on TKI's?  Was there any treatment to help 
>>>> the
>>>> liver?
>>>> 
>>>> God bless you all.
>>>> 
>>>>             Joyce in IL
>>>> 
>>>> 
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