Hello everyone.  I have not had time to contribute for awhile.  But I must let 
you all know the results of my husband's PCR at his last visit to Dr Talpaz.  
He was taken off Sprycel due to pleural effusion and we were hoping his 
undetectable would hold....but it did not.  He was subsequently put on bosulif 
and not showing much improvement after 3 months.  So his dosage was changed 
from 100 mg to 200 mg.  And now, after 3 more months, his PCR went from 8.7 to 
0.127!!  Hopefully in another 3 months he will once again reach undetectable.

The downside of his test results is that the liver function tests have 
increased a lot.  The doctor will not really say that bosulif is to blame, but 
nothing else has changed.  Has anyone of you CML warriors had any problems with 
the liver while on TKI's?  Was there any treatment to help the liver?

God bless you all.

            Joyce in IL


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