Hi Beth and so sorry about your liver enzymes. I hope you do good on your time off. I never do As my blood counts zoar when not kept in check. I am in my 7th month of ponatinib. Hang in there warrior.
My Motto: Faith and Pills Jeanie 🐟🐟18,s Dx 1/2004. CML Leukemia Started Gleevec 2/2004 Started Tasigna 9/2009 Started Sprycel 11/2009 Started Ponatinib January 2015 Dr Balducci Moffitt Cancer Center > On Jul 25, 2015, at 12:35 PM, Joyce Mesnarich <joy...@htc.net> wrote: > > Thanks Beth, > I think these TKIs are so new that they do not fully know all the side > effects, and especially not the long term ones. We are confident in his > doctor and he is watching it closely. Have you reached "undetectable" on > your low dose of tasigna? > Thanks for your good thoughts. > Joyce in IL > > >> On Jul 24, 2015, at 10:36 PM, bkbarney via CMLHope wrote: >> >> Hi Joyce, I am so glad that your husband's CML numbers are going in the >> right direction. The cml journey is often a balancing act, between the right >> dosage and side effects...Maybe your husband could be on 150 of busutinif >> with time??? It seems that 200 put him close to remission. I had to go off >> tasigna because of elevated liver enzymes, 10 X normal. Going off the med >> for a short time to give the liver a rest, and then using the lowest >> possible successful dosage...seems to work for some people. I hope your >> husband's liver calms down. I will keep my fingers crossed. 18's Beth >> >> -----Original Message----- >> From: Joyce Mesnarich <joy...@htc.net> >> To: cmlhope <cmlhope@googlegroups.com> >> Sent: Fri, Jul 24, 2015 7:50 pm >> Subject: Re: [CMLHope] New results >> >> Jeanie, >> I know you have been dealing with that pain for a long time. Medicine has >> come so far and yet the Good Lord holds some secrets from us. I hope in >> Sept they will get a clue as to the pain's cause. >> Joyce in IL >> >> >> On Jul 24, 2015, at 11:20 AM, 'Icandoallttc' via CMLHope wrote: >> >> Just wanted to say that I take OTC pain killers and have tried prescription >> ones. I have a right side pain that won't go away and they can't find out >> what it is. Nothing seems to help the pain. >> They are doing a ct scan in Sept to see if they can find it but they have >> already done that with no luck. Blessings >> >> My Motto: Faith and Pills >> Jeanie \uD83D\uDC1F\uD83D\uDC1F18,s >> Dx 1/2004. CML Leukemia >> Started Gleevec 2/2004 >> Started Tasigna 9/2009 >> Started Sprycel 11/2009 >> Started Ponatinib January 2015 >> Dr Balducci Moffitt Cancer Center >> >> On Jul 24, 2015, at 12:14 PM, "'Icandoallttc' via CMLHope" < >> cmlhope@googlegroups.com> wrote: >> >> Hi Joyce. >> It looks like your liver counts are 1-10% common to increase on that drug. >> Read the information that comes with the meds. Read the whole document >> through. >> They will stabilize as well as other side effects. >> It seems I will go from one side effect to another as time passes. >> Fight on. Good luck. >> >> My Motto: Faith and Pills >> Jeanie \uD83D\uDC1F\uD83D\uDC1F18,s >> Dx 1/2004. CML Leukemia >> Started Gleevec 2/2004 >> Started Tasigna 9/2009 >> Started Sprycel 11/2009 >> Started Ponatinib January 2015 >> Dr Balducci Moffitt Cancer Center >> >> On Jul 23, 2015, at 11:43 PM, Joyce Mesnarich < joy...@htc.net> wrote: >> >> Jeanie, >> Thanks for your interest and suggestion. We have gone over all his other >> meds with doctors and nothing should affect the liver. He doesn't take any >> OVC pain meds, or any pain meds. And he does not drink alcohol. The >> primary doctor says that the drug information for bosulif says it can cause >> liver problems, but Dr Talpaz is less certain of that and he is the >> specialist. He says he is watching it closely and I guess we will just >> trust him. Wayne is getting blood tests every other week locally and they >> are sent to Dr Talpaz. The liver enzyme levels seem to have stabilized, >> although they are elevated. As you say, faith and pills. One of Wayne's >> mottos is "Better living through chemistry". LOL I think that used to be >> part of a TV ad for a large chemical company, maybe Du Pont or Monsanto. >> >> Joyce in IL >> >> >> On Jul 23, 2015, at 11:32 AM, 'Icandoallttc' via CMLHope wrote: >> >> Be careful with his diet. Ovc pain pills hurt the liver as well as other >> drugs we take. Ask your pharmacy if any other drugs he take are hurting his >> liver. It's hard but maybe they can figure out something. >> Good luck. >> >> My Motto: Faith and Pills >> Jeanie \uD83D\uDC1F\uD83D\uDC1F18,s >> Dx 1/2004. CML Leukemia >> Started Gleevec 2/2004 >> Started Tasigna 9/2009 >> Started Sprycel 11/2009 >> Started Ponatinib January 2015 >> Dr Balducci Moffitt Cancer Center >> >> On Jul 22, 2015, at 2:01 PM, lrc lrc < kneesrb...@gmail.com> wrote: >> >> Joyce does he drink alcohol? >>> On Jul 22, 2015 1:43 PM, "margood18 via CMLHope" < >>> cmlhope@googlegroups.com> wrote: >>> Joyce, so glad to hear that your husband's PCR is lower and I hope that his >>> liver function will steady. Best wishes to both of you. >>> >>> Marcie >>> >>> >>> -----Original Message----- >>> From: Joyce Mesnarich < joy...@htc.net> >>> To: cmlhope < cmlhope@googlegroups.com> >>> Sent: Wed, Jul 22, 2015 12:16 pm >>> Subject: [CMLHope] New results >>> >>> Hello everyone. I have not had time to contribute for awhile. But I must >>> let >>> you all know the results of my husband's PCR at his last visit to Dr >>> Talpaz. He >>> was taken off Sprycel due to pleural effusion and we were hoping his >>> undetectable would hold....but it did not. He was subsequently put on >>> bosulif >>> and not showing much improvement after 3 months. So his dosage was changed >>> from >>> 100 mg to 200 mg. And now, after 3 more months, his PCR went from 8.7 to >>> 0.127!! Hopefully in another 3 months he will once again reach >>> undetectable. >>> >>> The downside of his test results is that the liver function >>> tests have increased a lot. The doctor will not really say that bosulif is >>> to >>> blame, but nothing else has changed. Has anyone of you CML warriors had any >>> problems with the liver while on TKI's? Was there any treatment to help the >>> liver? >>> >>> God bless you all. >>> >>> Joyce in IL >>> >>> >>> -- >>> -- >>> >>> [CMLHope] >>> A support group of >>> http://cmlhope.com >>> ------------------------------------------------- >>> >>> You >>> received this message because you are subscribed to the Google Groups >>> "CMLHope" >>> group. >>> To post to this group, send email to CMLHope@googlegroups.com >>> To >>> unsubscribe from this group, send email to >>> cmlhope-unsubscr...@googlegroups.com >>> For more options, visit this group at >>> http://groups.google.com/group/CMLHope >>> --- >>> You received this message because >>> you are subscribed to the Google Groups "CMLHope" group. >>> To unsubscribe from >>> this group and stop receiving emails from it, send an email to >>> cmlhope+unsubscr...@googlegroups.com. >>> For more options, visit >>> https://groups.google.com/d/optout. >>> >>> -- >>> -- >>> [CMLHope] >>> A support group of http://cmlhope.com >>> 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