Joyce, so glad to hear that your husband's PCR is lower and I hope that his 
liver function will steady.  Best wishes to both of you.


Marcie



-----Original Message-----
From: Joyce Mesnarich <joy...@htc.net>
To: cmlhope <cmlhope@googlegroups.com>
Sent: Wed, Jul 22, 2015 12:16 pm
Subject: [CMLHope] New results


Hello everyone.  I have not had time to contribute for awhile.  But I must let
you all know the results of my husband's PCR at his last visit to Dr Talpaz.  He
was taken off Sprycel due to pleural effusion and we were hoping his
undetectable would hold....but it did not.  He was subsequently put on bosulif
and not showing much improvement after 3 months.  So his dosage was changed from
100 mg to 200 mg.  And now, after 3 more months, his PCR went from 8.7 to
0.127!!  Hopefully in another 3 months he will once again reach
undetectable.

The downside of his test results is that the liver function
tests have increased a lot.  The doctor will not really say that bosulif is to
blame, but nothing else has changed.  Has anyone of you CML warriors had any
problems with the liver while on TKI's?  Was there any treatment to help the
liver?

God bless you all.

            Joyce in IL


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