Le 26/02/2016 10:08, Jerry a écrit :
I don't know if you could infer that from my previous comments, but
more or less what happens.

I could infer, more or less :)

The luatex process starts almost as soon
as I hit Reconfigure. I Quit it (force quit not required) using
Activity Monitor. LyX is unresponsive for about a minute, then the
message

The system has been reconfigured. You need to restart LyX to make use
of any updated document class specifications.

appears. At that point, LyX seems to operate normally. Also it
operates normally after quitting and relaunching.

This makes me think that we experienced the same issue. I would suggest to make sure that LyX does not call inadvertently the wrong luatex binary from your older texlive 2013 installation. If you're sure it is running the most recent version, then you could try to temporarily remove non-essential fonts and see if it gets quicker. (I do not know how to safely do this on your OS.)

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