[ccp4bb] Postdoctoral Position Available in the Karakas Lab at Vanderbilt University School of Medicine

[Karakas, Erkan]

The Karakas Lab at Vanderbilt University School of Medicine, located in 
Nashville, TN, is seeking a highly motivated individual to fill an NIH-funded 
postdoctoral position. Our research group is dedicated to unraveling the 
molecular mechanisms of ion channels using state-of-the-art structural biology 
approaches. The laboratory, situated within the Department of Molecular 
Physiology and Biophysics, offers access to cutting-edge cores specializing in 
crystallography, cryo-electron microscopy (cryo-EM), mass spectrometry, and a 
range of advanced biophysical instrumentation. 

We invite you to explore our recent research publications that demonstrate our 
significant contributions to understanding diverse ion channels and their 
underlying structural basis:

Structural basis for activation and gating of IP3 receptors 
(https://www.nature.com/articles/s41467-022-29073-2)
Cryo-EM structures of an LRRC8 chimera with native functional 
properties reveal heptameric assembly (https://elifesciences.org/articles/82431)

As a Postdoctoral Researcher in our lab, you will work closely with Dr. 
Karakas, utilizing cutting-edge technologies such as X-ray crystallography, 
cryo-EM, and various biophysical techniques. You will have the freedom to 
design and conduct experiments, analyze data, and contribute to the development 
of novel methodologies.

Candidates should have a Ph.D. in biochemistry, biophysics, or related fields. 
While prior experience in X-ray crystallography, cryo-EM, or electrophysiology 
would be advantageous, it is not required. We welcome applicants with diverse 
backgrounds and a strong interest in applying structural biology techniques to 
study ion channels.

To apply for this position, please submit the following documents via e-mail to 
Erkan Karakas at erkan.kara...@vanderbilt.edu:
*   Cover Letter: Please provide a cover letter that outlines your research 
interests, goals, and how your background aligns with our research focus.
*   CV: Attach a current curriculum vitae highlighting your educational 
background, research experience, and publications.
*   References: Include the contact information (2-3 references) who can 
provide insight into your qualifications and potential as a postdoctoral 
researcher.

We encourage interested candidates to apply as soon as possible. The position 
will remain open until filled.

For any additional inquiries or further information, please do not hesitate to 
contact Erkan Karakas at erkan.kara...@vanderbilt.edu or by phone at (615) 
343-4494.

Sincerely,

-

Erkan Karakas, PhD
Assistant Professor of Molecular Physiology and Biophysics
Vanderbilt University School of Medicine 
2215 Garland Avenue
Light Hall 741A
Nashville, TN 37232

e-mail: erkan.kara...@vanderbilt.edu
Phone: (615) 343-4494



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[ccp4bb] Postdoctoral position available

[Herwig Schüler]

A postdoctoral position in biochemistry and structural biology is available at 
Lund University, Sweden.
The focus of the position will be bacterial toxin-antitoxin systems and we will 
use X-ray crystallography, cryo-EM and NMR within the project.
Please email me for further details and how to apply.
Sincerely, Herwig Schüler
herwig.schuler(at)biochemistry.lu.se



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[ccp4bb] Postdoctoral position available at UCL/Birkbeck ISMB to work on bacterial secretion systems

[Gabriel Waksman]

Postdoctoral Researcher – cryo-Electron Microscopy - fixed term – for up to 33 
months

At Birkbeck/UCL -ISMB- Gabriel Waksman Lab

The ISMB is seeking a Post-Doctoral Research Assistant to carry out structural 
analysis of the Type IV Secretion System by cryo-electron microscopy with 
Professor Gabriel Waksman. The laboratory has been exceptionally productive 
over the years in this area (see Science, 2009, 323:266-268; Nature, 2009, 
462:1011-1015; Nature, 2014, 508:550-553; Cell, 2016, 166:1436–1444; Cell, 
2017, 169:708–721; Nature. 2022, 607:191-196). The research programme is funded 
by a grant from the Wellcome Trust. Further details on the research group and 
on type IV secretion can be found at 
http://www.ismb.lon.ac.uk/gabriel-waksman/homepage.htm 
.

Applicants should have a PhD in Structural Molecular Biology, and experience in 
Electron Microscopy, Image Processing, Biophysics, Biochemistry or related 
areas.

To apply (and read further details on job description), click on the following 
link: https://cis7.bbk.ac.uk/vacancy/postdoctoral-researcher-511711.html 


Closing date: 15th February 2023 - Tentative interview date: 28th February 2023


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[ccp4bb] Postdoctoral position available at UCL/Birkbeck ISMB to work on bacterial secretion systems

[Gabriel Waksman]

Postdoctoral Researcher – cryo-Electron Microscopy - fixed term – for up to 36 
months

At Birkbeck/UCL -ISMB- Gabriel Waksman Lab

The ISMB is seeking a Post-Doctoral Research Assistant to carry out structural 
analysis of the Type IV Secretion System by cryo-electron microscopy with 
Professor Gabriel Waksman. The laboratory has been exceptionally productive 
over the years in this area (see Science, 2009, 323:266-268; Nature, 2009, 
462:1011-1015; Nature, 2014, 508:550-553; Cell, 2016, 166:1436–1444; Cell, 
2017, 169:708–721; Nature. 2022, 607:191-196). The research programme is funded 
by a grant from the Wellcome Trust. Further details on the research group and 
on type IV secretion can be found at 
http://www.ismb.lon.ac.uk/gabriel-waksman/homepage.htm.

Applicants should have a PhD in Structural Molecular Biology, and experience in 
Electron Microscopy, Image Processing, Biophysics, Biochemistry or related 
areas.

To apply (and read further details on job description), click on the following 
link: https://cis7.bbk.ac.uk/vacancy/postdoctoral-researcher-503868.html 


Closing date: 15th November 2022 - Tentative interview date: 29th November 2022




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[ccp4bb] Postdoctoral position available in Bethesda, MD, US

[Marzena Pazgier]

A postdoctoral position is available immediately to participate in an
interdisciplinary research program in structural immunology in the
laboratory of Dr. Pazgier (https://www.usuhs.edu/node/68252) at the
Uniformed Services University of the Health Sciences (USU) in Bethesda, MD.
Candidates are expected to work on ongoing research projects in structural
biology with the aim to understand the molecular basis of the adaptive
immune response to HIV-1 and Sars-Cov-2 and the ultimate goal to develop
new protein-based therapeutics and novel vaccine concepts. Strong research
interests and experience in molecular cloning, protein expression,
molecular interaction analysis, X-ray crystallography and/or Cryo-EM, as
well as outstanding interpersonal, oral, and written communication skills,
are required for this post. Candidates with an immunological background are
invited to apply.

Candidates need to be highly motivated individuals who enjoy working as
part of a dynamic, collaborative and multidisciplinary team. Preference
will be given to candidates with exceptionally strong experimental skills,
a strong record of peer-reviewed publications, and a demonstrated
commitment to basic and translational research. Qualified candidates should
have a doctorate in chemistry/biochemistry, microbiology, immunology or a
closely-related field. Candidates at any career stage are invited.

USU is in Bethesda, MD directly across the street from the NIH, and is
therefore part of an extraordinarily vibrant local biomedical research
community. Our research projects take advantage of recently established
Core facilities for Nextgen sequencing, Bioinformatics and Structural
Biology analyses. USU has a strongly collaborative environment, with weekly
Immunology data club and journal club meetings, as well as regular research
seminars featuring local and invited speakers.

Please contact Dr. Pazgier directly at marzena.pazg...@usuhs.edu.



--



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[ccp4bb] Postdoctoral position available in the Laboratory of Cell Biology, National Cancer Institute, NIH

[Xia, Di (NIH/NCI) [E]]

Dear structural biologists,

The Section of Structural Biology in the Laboratory of Cell Biology, Center for 
Cancer Research, National Cancer Institute, NIH has an opening for a 
Postdoctoral Fellow with a recent Ph.D. This individual will be working on 
"structure and function of proteins involving in cancer drug resistance ".  Our 
group is equipped with start-of-the-art instruments for carrying out molecular 
and cellular biology experiments and has assured access to a synchrotron beam 
line at APS and to an intramural EM facility equipped with an FEI Krios 
microscope and Gatan K3 detector. The successful candidate should have training 
in molecular biology, biochemistry, and protein purification for target protein 
production. Experience in cryo-EM and/or X-ray crystallography is a plus. NIH 
has a welcoming, collaborative and vibrant environment for biomedical research. 
Our campus is located in Bethesda, Maryland. Interested individuals should send 
their applications, consisting of a CV, a statement of research interest, and 
three letters of recommendation, to Dr. Di Xia via Email at 
x...@mail.nih.gov. The application deadline is 
October 31st, 2022.




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[ccp4bb] Postdoctoral Position available at the Ohio State University

[Krishna Chinthalapudi]

Dear All,



Applications are invited for a postdoctoral scientist position in the
laboratory of Dr. Krishna Chinthalapudi at the Ohio State University. The
research project focuses on understanding the role of cytoskeletal proteins
in health and disease. We combine state-of-the-art structural biology
approaches including cryo-EM and X-ray crystallography with biochemical,
biophysical, and cell biological methods to investigate how protein
structure is related to its function. Our laboratory is equipped with
state-of-the-art instrumentation for the proposed studies and has generous
access to a Titan Krios G3i Cryo-TEM and a K3 direct electron detector,
imaging phase plates, STEM/TEM tomography, and an image spherical
aberration corrector. In addition, my lab has access to Glacios with a
falcon III detector and Ceta-D camera for MicroED analysis at the
world-class Center for Electron Microscopy and Analysis (CEMAS) at the Ohio
State University.



Candidates with a recent Ph.D. degree and prior experience in structural
biology with interests in cytoskeletal protein structure-function studies
are encouraged to apply.



To be considered for this position, please email your curriculum vitae and
a short cover letter with research experience and interests to Krishna
Chinthalapudi (*krishna.chinthalap...@osumc.edu
*).



Thank you,
Krishna



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[ccp4bb] Postdoctoral Position Available

[Troy Johnson]

Hi All, 
This post is to bring your attention to a postdoctoral position currently 
available in the Structural Chemistry group, part of the Institute for Applied 
Cancer Science (IACS) within the Therapeutics Discovery Division of MD Anderson 
Cancer Center. The highly collaborative teams within IACS are focused on 
discovering and developing the next generation of small-molecule therapeutics 
targeting unmet medical needs in oncology and neurodegeneration. 

This is a unique opportunity to learn how structural biology contributes to the 
development of novel therapeutics by participating in the drug discovery 
process as a team member. The postdoctoral researcher will have the opportunity 
to work in a project-driven environment with a multi-disciplinary team of 
scientists from several functional groups (eg. in vitro pharmacology, medicinal 
and computational chemistry) all within a highly respected academic and 
clinical setting.

We are seeking an individual with a background in structural biology, including 
protein expression and purification, protein crystallization, and X-ray 
crystallography structure determination. Experience with biophysical techniques 
to measure binding interactions (eg. ITC, SPR, MST), fragment based drug 
discovery and/or structure determination of membrane proteins is not required, 
but would be advantageous. We want a motivated individual to join us in our 
quest to discover, develop, and deliver more effective treatments to our 
patients.

Interested individuals should send an introductory email and CV to 
therapeut...@mdanderson.org

To apply visit the link below:
https://www.mdanderson.org/about-md-anderson/careers/open-trainee-positions.html
Applied Cancer Science - Req #: 600140-202204261644



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[ccp4bb] Postdoctoral position available in Bethesda, MD, US

[Pazgier, Marzena]

A postdoctoral position is available immediately to participate in an
interdisciplinary research program in structural immunology in the
laboratory of Dr. Pazgier (https://www.usuhs.edu/node/68252) at the
Uniformed Services University of the Health Sciences (USU) in Bethesda, MD.
Candidates are expected to work on ongoing research projects in structural
biology with the aim to understand the molecular basis of the adaptive
immune response to HIV-1 and Sars-Cov-2 and the ultimate goal to develop
new protein-based therapeutics and novel vaccine concepts. Strong research
interests and experience in molecular cloning, protein expression,
molecular interaction analysis, X-ray crystallography and/or Cryo-EM, as
well as outstanding interpersonal, oral, and written communication skills,
are required for this post. Candidates with an immunological background are
invited to apply.


Candidates need to be highly motivated individuals who enjoy working as
part of a dynamic, collaborative and multidisciplinary team. Preference
will be given to candidates with exceptionally strong experimental skills,
a strong record of peer-reviewed publications, and a demonstrated
commitment to basic and translational research. Qualified candidates should
have a doctorate in chemistry/biochemistry, microbiology, immunology or a
closely-related field. Candidates at any career stage are invited.


USU is in Bethesda, MD directly across the street from the NIH, and is
therefore part of an extraordinarily vibrant local biomedical research
community. Our research projects take advantage of recently established
Core facilities for Nextgen sequencing, Bioinformatics and Structural
Biology analyses. USU has a strongly collaborative environment, with weekly
Immunology data club and journal club meetings, as well as regular research
seminars featuring local and invited speakers.


Candidates should apply to the Henry M. Jackson Foundation:
http://careers.hjf.org submitting a CV plus names and contact information
for 3 references.

Note: you may also directly contact Dr. Pazgier directly,
marzena.pazg...@usuhs.edu.

--



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[ccp4bb] Postdoctoral position available in Australia

[Forwood, Jade]

Dear All,

We have a 3 year postdoctoral position in our lab investigating viral:host 
protein interactions. Our lab uses X-ray crystallography and cryoEM approaches, 
and we have regular access to the Australian Synchrotron. We are based in Wagga 
Wagga, NSW, Australia. For further information, please see our website, and/or 
feel free to contact me on jforw...@csu.edu.au.

http://csusap.csu.edu.au/~jforwood/

Kind regards,

Jade.

Prof Jade Forwood
ARC Future Fellow
School of Biomedical Sciences
Charles Sturt University
Wagga Wagga 2650
Australia
Ph: +61 2 693 32317
Fx:  +61 2 693 32587
http://csusap.csu.edu.au/~jforwood/


[Charles Sturt University]

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[ccp4bb] Postdoctoral Position Available in Leiden

[Zach Armstrong (Leiden University)]

Hi All!

The Armstrong lab is recruiting a postdoctoral fellow with extensive experience 
in structural biology for a 3 year, funded project to study human and viral 
enzymes that modify carbohydrates.
A PhD in Biochemistry, Biophysics, Structural Biology (or a related field), 
experience in protein expression and purification, and excellent English 
communication and writing skills are required. Membrane protein experience is a 
plus (but not required).

The Armstrong lab is part of the bio-organic synthesis group within the 
Institute of Chemistry at Leiden University: 
https://www.universiteitleiden.nl/en/science/chemistry

For more information about the position, contact Zach Armstrong : 
z.w.b.armstr...@lic.leidenuniv.nl
to apply see the adverisemenet: https://www.linkedin.com/jobs/view/2786149594/

 
/Zach 



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[ccp4bb] postdoctoral position available

[Srivastava, Dhiraj]

I am posting this advertisement on behalf of Prof. Nikolai Artemyev.


A postdoctoral position is available immediately at the Department of Molecular 
Physiology and Biophysics, University of Iowa Carver College of Medicine to 
study the molecular mechanisms of vertebrate visual transduction. We are using 
multiple approaches, including protein structure-function analysis, 
biochemistry, structural and molecular biology. A successful applicant will 
have a PhD, experience in biochemistry/structural and molecular biology, and a 
relevant publication record. Experience in x-ray crystallography and/or cryo-EM 
is preferred. Salary is commensurate with experience.

The University of Iowa is located in Iowa City, a dynamic college-town within 
driving distance of Chicago, St. Louis, and Minneapolis. Iowa City offers a 
culturally rich and highly academic environment supportive of the arts and 
sciences. The University of Iowa is part of the Molecular Biology Consortium 
that gives us substantial beam time for crystallographic studies at the 4.2.2 
ALS beamline (Lawrence Berkeley National Labs). We have active proposals at the 
Pacific Northwest Cryo-EM Center (PNCC) in Portland, OR.


Interested applicants should send a summary of previous research and a CV with 
names of at least two referees by e-mail to 
nikolai-artem...@uiowa.edu



Thank you
Dhiraj



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[ccp4bb] Postdoctoral Position Available at Rutgers University

[Matthew Neiditch]

An NIH-funded postdoctoral position is available in the Neiditch lab at Rutgers 
University - New Jersey Medical School to develop new anti-TB drugs that 
inhibit cell wall biosynthesis and respiration. In addition to a Ph.D., the 
ideal candidate will have a background in macromolecular X-ray crystallography, 
cryo-EM, biochemistry, protein purification, and molecular biology. Candidates 
with demonstrated success in another field and a strong commitment to learning 
X-ray crystallography and cryo-EM will also be considered. A working knowledge 
of bacterial genetics is a plus. The ability to communicate ideas and work 
collaboratively as a member of a highly motivated team is essential.

Please submit your CV to matthew.neidi...@rutgers.edu with the subject line 
Postdoctoral Position Applicant.

Matthew Neiditch
Dept. of Microbiology, Biochemistry, and Molecular Genetics
New Jersey Medical School
Rutgers University



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[ccp4bb] Postdoctoral position available at the National Cancer Institute, NIH in Bethesda, MD, USA

[Xia, Di (NIH/NCI) [E]]

Dear colleagues,

The Section of Structural Biology of Membrane Proteins in the Laboratory of 
Cell Biology, Center for Cancer Research, National Cancer Institute, NIH has an 
opening for Postdoctoral Fellow with a recent Ph.D. in Biology and training in 
cryo-EM and/or X-ray crystallography. This individual will be working on 
"Mechanistic investigation of cellular drug resistance ".  The project involves 
structural studies of cytosolic and mitochondrial proteins that are targets of 
antimicrobial compounds.  It is anticipated that multiple structural techniques 
will be employed, involving the use of X-ray crystallography and Cryo-EM to 
illuminate structural aspects of target protein’s response to drug treatment.  
Our group has assured access to a synchrotron beam line at APS and to an 
intramural EM facility equipped with an FEI Krios microscope and Gatan K3 
detector. The successful candidate should have practical experiences in 
molecular biology and protein purification for target protein production. 
Experience in mitochondrial proteins is a plus. NIH has a welcoming, 
collaborative and vibrant environment for biomedical research. Our campus is 
located in Bethesda, Maryland. Interested individuals should send their 
Applications, consisting of a CV, a statement of research interest, and three 
letters of recommendation, to Dr. Di Xia via Email at 
x...@mail.nih.gov

Best wishes,

Di Xia, Ph.D. Senior Investigator



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[ccp4bb] Postdoctoral Position Available at Rutgers University

[Matthew Neiditch]

An NIH-funded postdoctoral position is available at Rutgers University - New 
Jersey Medical School to study the structure and function of novel bacterial 
cytidine deaminases and their regulatory RNAs. In addition to a Ph.D., the 
ideal candidate will have a strong background in macromolecular X-ray 
crystallography, cryoEM, biochemistry, protein purification, and molecular 
biology. Candidates with demonstrated success in another field and a strong 
commitment to learning X-ray crystallography and cryoEM will also be 
considered. A working knowledge of bacterial genetics is a plus. This project 
is an important component of a long-term collaboration with Dr. Christopher 
Waters (Michigan State University), and the ability to communicate ideas and 
work collaboratively as a member of a highly motivated team is essential.

Please submit your CV to matthew.neidi...@rutgers.edu with the subject line 
Postdoctoral Position Applicant.

Matthew Neiditch
Dept. of Microbiology, Biochemistry, and Molecular Genetics
New Jersey Medical School
Rutgers University



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[ccp4bb] Postdoctoral position available at the Institute of Cancer Research, London UK

[Rob Van Montfort]

The Institute of Cancer Research (ICR), London, is one of the world’s most 
influential cancer research institutes, with an outstanding record of 
achievement dating back more than 100 years. Under the leadership of our Chief 
Executive, Professor Paul Workman FMedSci, the ICR is ranked as the UK’s 
leading academic research centre. Together with our partner The Royal Marsden 
Hospital, we are rated in the top four cancer centres globally. The ICR is 
committed to attracting, developing and retaining the best minds in the world 
to join us in our mission – to make the discoveries that defeat cancer.


The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of 
Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, 
comprising around 160 staff dedicated to the discovery and development of novel 
therapeutics for the treatment of cancer. The CTU’s exciting goal is to 
discover high quality small molecule drug candidates and to progress these to 
clinical trial. All the scientific disciplines are in place to make this 
possible, including medicinal chemistry, biology, structural biology, assay 
scientists, drug metabolism and clinical specialists.

A postdoctoral position is available in Dr Rob van Montfort’s Hit Discovery and 
Structural Design Team within the CTU in Sutton. The Post-doc will be involved 
in the structure determination of protein complexes by cryo-electron microscopy 
(cryoEM) as part of CTU research programmes in targeted protein degradation. 
The postholder will be responsible for sample preparation, structure 
determination by cryoEM, and subsequent structural analysis of protein 
complexes and will interact closely with the structural biologists and biology, 
computational chemistry and medicinal chemistry teams at the CTU. The 
successful candidate will also be part of the Division of Structural Biology, 
located in Chelsea, in which the structural biologists in Dr van Montfort’s 
team are embedded, and will have access to its state-of-the art cryoEM 
facilities. These include an in-house Glacios and 30% direct access to a Titan 
KRIOS located at the Francis Crick Institute. Both microscopes are equipped 
with Falcon III detectors and volta phase plates (VPP). In addition, we have 
excellent access to the electron bioimaging Centre (eBIC) at the Harwell 
Science and Innovation campus, Didcot, UK. The postholder will be expected to 
work across the two sites in Chelsea, London and Sutton, Surrey.

Applicants must have a PhD (or equivalent) in a biological or physical science, 
with experience in cryo-EM specimen preparation and data processing. Experience 
in single particle electron microscopy is essential for this post. Experience 
in molecular biology and protein expression in insect cells will be an 
advantage.

The starting salary for the position will be in the range £32,844 to £40,902 
p.a. inclusive (based on previous post-doctoral experience) and the post is 
offered on a fixed term contract of 18 months. Informal enquiries to 
rob.vanmontf...@icr.ac.uk or 
yann-vai.lebi...@icr.ac.uk.
Please DO NOT send your application to Dr van Montfort or Dr Le Bihan, but 
apply via the e-recruitment system on our website 
www.icr.ac.uk.


Closing date:  21st February 2021


Dr. Rob van Montfort
Reader in Structural Biology and Cancer Drug Discovery
Team Leader Hit Discovery and Structural Design
Divisions of Cancer Therapeutics and Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG
UK

Tel:
+44-(0)20-8722-4364 (Sutton)
+44-(0)20-7153-5142 (Chelsea)
Email: rob.vanmontf...@icr.ac.uk


The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company 
Limited by Guarantee, Registered in England under Company No. 534147 with its 
Registered Office at 123 Old Brompton Road, London SW7 3RP.

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[ccp4bb] Postdoctoral position available at the Institute of Cancer Research, London UK

[Rob Van Montfort]

The Institute of Cancer Research, London, is one of the world’s most 
influential cancer research institutes, with an outstanding record of 
achievement dating back more than 100 years. Under the leadership of our Chief 
Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading 
academic research centre. Together with our partner The Royal Marsden, we are 
rated in the top five cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in 
the world to join us in our mission – to make the discoveries that defeat 
cancer.

The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of 
Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, 
comprising around 160 staff dedicated to the discovery and development of novel 
therapeutics for the treatment of cancer. The CTU’s exciting goal is to 
discover high quality small molecule drug candidates and to progress these to 
clinical trial. All the scientific disciplines are in place to make this 
possible, including medicinal chemistry, biology, structural biology, assay 
scientists, drug metabolism and clinical specialists.
A postdoctoral position is available in Dr Rob van Montfort’s Hit Discovery and 
Structural Design Team within the CTU in Sutton. The Post-doc will be involved 
in X-ray crystallography, fragment-based screening and structure-based drug 
design and will be responsible for protein expression, purification, 
crystallisation, structure determination and structural analysis of 
protein-ligand complexes from one of the CTU’s drug discovery programmes. The 
successful candidate will also be part of the Division of Structural Biology, 
located in Chelsea, in which the structural biologists in Dr van Montfort’s 
team are embedded, and will have access to state-of-the art crystallisation 
facilities, in-house X-ray sources and excellent access to synchrotrons. The 
successful candidate will interact closely with the biology, computational 
chemistry and medicinal chemistry teams at the CTU, and will therefore be 
expected to work across the two sites in Chelsea, London and Sutton, Surrey.
Applicants must have a PhD in a biological or physical science, and experience 
in macromolecular crystallography (to include protein biochemistry, protein 
crystallisation and protein crystallography). Experience in molecular biology, 
protein expression in insect cells, structure-based drug design, and/or 
biophysics will be an advantage.
The starting salary for the position will be in the range £32,844 to £40,137 
p.a. inclusive (based on previous post-doctoral experience) and the post is 
offered on a fixed term contract of 1 year. Informal enquiries to 
rob.vanmontf...@icr.ac.uk or yann-vai.lebi...@icr.ac.uk.
Please DO NOT send your application to Dr van Montfort or Dr Le Bihan, but 
apply via the e-recruitment system on our website 
www.icr.ac.uk
For more details see: 
https://icr.tal.net/vx/lang-en-GB/mobile-0/appcentre-1/brand-4/xf-a7200b374103/candidate/so/pm/1/pl/1/opp/1110-Postdoctoral-Training-Fellow-Protein-Crystallography/en-GB


Dr. Rob van Montfort
Reader in Structural Biology and Cancer Drug Discovery
Team Leader Hit Discovery and Structural Design
Divisions of Cancer Therapeutics and Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG
UK

Tel:
+44-(0)20-8722-4364 (Sutton)
+44-(0)20-7153-5142 (Chelsea)
Email: rob.vanmontf...@icr.ac.uk


The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company 
Limited by Guarantee, Registered in England under Company No. 534147 with its 
Registered Office at 123 Old Brompton Road, London SW7 3RP.

This e-mail message is confidential and for use by the addressee only.  If the 
message is received by anyone other than the addressee, please return the 
message to the sender by replying to it and then delete the message from your 
computer and network.




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[ccp4bb] Postdoctoral position available at EMBL Hamburg

[Margret Fischer]

Dear all,
I would like to draw your attention to a postdoctoral Vacancy Notice in 
the research group of Dr. Matthias Wilmanns at the EMBL Hamburg Unit.


*Vacancy Notice: HH_00183*
Postdoctoral Fellowship: High-resolution structure and function of the 
multi-layered kidney slit diaphragm


Detailed information can be found under:
http://s.embl.org/HH00183


best wishes,
Margret

--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Postdoctoral position available

[M. Joanne Lemieux]

Applications are invited for a postdoctoral position to work on
crystallography of proteases. Experience in crystallography is preferred.
In addition, the successful candidate should be well versed in one or more
of the following areas: molecular biology, protein purification, and
membrane protein biochemistry. The candidate must be within five years of
attaining a PhD degree.

This is an opportunity to join a lab experienced in the expression and
crystallization of various enzymes, including soluble coronavirus proteases
(https://www.biorxiv.org/content/10.1101/2020.05.03.073080v2) and membrane
proteins (See *PNAS *(2007) 104(3):750-4, and *Science, *(2003)*. *
301:616-620),( http://www2.biochem.ualberta.ca/LemieuxLab/).  The
University of Alberta, located in Edmonton, Alberta (Canada), is home to a
large and interactive community of biomedical scientists, and facilities
for structural biology are excellent. Our department provides interaction
with numerous crystallographers. The Canadian Light Source (CLS)
synchrotron facility is located a short drive away. In addition, the
membrane protein research group provides a dedicated forum for membrane
protein research at the University of Alberta (http://www.mpdrg.com).

Edmonton, having a population of over 1 million, offers a
cosmopolitan environment with world-class performing arts, sports, culinary
and recreational opportunities.  In addition, the city’s proximity to the
Rocky Mountains including the towns of Jasper and Banff is an additional
bonus.

Salary is commensurate with training and experience at the CIHR standard
rates. A medical and dental benefit package is included with salary. The
University of Alberta hires on the basis of merit. We are committed to the
principle of equity in employment. We welcome diversity and encourage
applications from all qualified women and men, including persons with
disabilities, members of visible minorities, and Aboriginal persons. The
records arising from this competition will be managed in accordance with
provisions of the Alberta Freedom of Information and Protection of Privacy
Act (FOIPP).



Please direct CV, statement of interests including structures previously
solved, and a list of three references to Dr. M. Joanne Lemieux at the
following email address: joanne.lemieux@ualberta.cawith the subject
header: *PDF
application*.



M. Joanne Lemieux



**
M. Joanne Lemieux, Ph.D.
Professor
Director, Membrane Protein Disease Research Group
Department of Biochemistry
Faculty of Medicine & Dentistry
University of Alberta
Medical Sciences Bldg.
Office 4-53
Lab4-51
University of Alberta
Edmonton AB, T6G 2H7

office phone: 780-492-3586
lab phone:780-492-3465
fax: 780-492-0886

Lab web pages:
http://www2.biochem.ualberta.ca/LemieuxLab
http://www.biochem.ualberta.ca/faculty_detail.php?id=39#

Membrane Protein Disease Research Group:
http://www.mpdrg.com

NSERC Membrane Protein International Research Training Group:
http://www.mpdrg.com/index.php/international-linkages/


CONFIDENTIALITY WARNING
This communication is intended for the use of the recipient to which it is
addressed, and may contain confidential, personal, and/or privileged
information. Please contact me immediately if you are not the intended
recipient of this communication, and do not copy, distribute, or take
action relying on it. Any communication received in error, or subsequent
reply, should be deleted or destroyed.



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[ccp4bb] Postdoctoral position available in the area of Membrane Transport at Northwestern University

[Heather Pinkett]

Postdoctoral Position in Membrane Transport

The laboratory is seeking a highly motivated individual for a postdoctoral
fellow position in the field of protein structural biology. The individual
will join a  research team studying the structure and function of ABC
transporters.  Our laboratory is equipped with state-of-the art facilities
for x-ray crystallography, cryo-EM and protein biochemistry research.  We
are approximately an hour drive to Argonne National labs (APS).

An ideal applicant would be highly motivated with strong analytical skills
and enjoy working independently as well as in a collaborative environment.
A strong background in structural biology, protein expression and
biochemistry is a plus.  The position requires a Ph.D. in a related field
and less than one year of postdoctoral experience.

Applicants should email their CV and a summary of their research experience
to Dr. Heather Pinkett (h-pink...@northwestern.edu).


-- 
Heather W Pinkett, PhD

Associate Professor
Department of Molecular Biosciences
Northwestern University
2205 Tech Drive
Evanston, IL 60208-3500

Tel. (847) 467-4048
Office: Cook Hall 4133

Lab: Cook Hall 4161
Tel. (847) 467-0877

h-pink...@northwestern.edu
Twitter @LabPinkett
https://pinkettlab.northwestern.edu/




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[ccp4bb] Postdoctoral position available at the Basque Centre for Biophysics (Bilbao, SPAIN)

[David albesa-jove]

Dear colleagues,



We are currently looking for a postdoctoral researcher to join our lab.
Please see below for details:



*OFFER* – Postdoctoral Position (Two years)



*DEADLINE: *4th of February, 2020 at 17:00 h CET or until position is
filled.



*WHERE* – Basque Centre for Biophysics (Bilbao, SPAIN)



The Basque Centre for Biophysics is an international research center of
excellence with the main aim of promoting a multidisciplinary research
program in the field of Biophysics and its application in the areas of
Biotechnology and Health, the center is a joint effort of the University of
the Basque Country (UPV/EHU) and the Spanish National Research Council
(CSIC).



*Description of the position offered*

The position is available in the Structural Microbiology Laboratory led by
Dr. David Albesa-Jové at the Basque Centre for Biophysics (Bilbao, Spain).
Our group was recently established and focuses on understanding the
biological function of virulence factors and essential enzymes in human
pathogenic bacteria. Please, see below for some recent publications. The
laboratory is well equipped for all aspects of molecular biology,
biochemistry, biophysics and crystallography. We also have regular access
to synchrotron radiation at Diamond (UK) and ALBA (Spain) through BAG
applications.



1.*Albesa-Jové** D, et al.: Structural Snapshots of
α-1,3-Galactosyltransferase
with Native Substrates: Insight into the Catalytic Mechanism of Retaining
Glycosyltransferases.

*Angew Chemie Int Ed* 2017, 56:14853–14857. *IF. 12.26 *corresponding
author*


2.Planamente S, Salih O, Manoli E, *Albesa**‐**Jové D*, Freemont PS,
Filloux A: TssA forms a gp6‐like ring attached to the type VI secretion
sheath.

*EMBO J.* 2016, 35:1613–1627. *IF. 11.23*


3.*Albesa-Jové *D, et al.: Structural basis for selective recognition
of acyl chains by the membrane-associated acyltransferase PatA

   *Nature Communications*. 2016, 7:10906. *IF. 11.89*


4.*Albesa-Jové* D, et al.: A native ternary complex in crystal reveals
the catalytic mechanism of a retaining glycosyltransferase.

*Angew Chem Int Ed Engl.* 2015; 54(34): 9898-902. *IF. 12.26*


5.Giganti D, *Albesa-Jové* D, et al.: Secondary structure reshuffling
modulates glycosyltransferase function at the membrane.

*Nature Chemical Biology.* 2015, 11(1): 16–18. *IF. 12.15*


6.Andrés A1, *Albesa-Jové1* D, et al.: Structural basis of chitin
oligosaccharide deacetylation.

*Angew Chem Int Ed Engl.* 2014, 53(27): 6882–6887. *IF. 12.26 1equal
contribution*



*Education and Experience Required*

We are seeking a highly motivated individual with a strong background in
structural biology, including protein expression and purification, protein
crystallization, and X-ray crystallography. Outstanding postdoctoral
candidates will also have the necessary support to apply for the Ikerbasque
Fellows 2020 call. These 5-year Fellowships are directed to promising young
postdoctoral researchers (applicants must have their PhD completed between
2009 and 2017) and are intended to offer a track towards independent
research as a group leader. Ikerbasque Fellows in their 5th year can be
assessed for permanent group leader positions. More details about the
previous 2019 Ikerbasque Fellows call can be found here:

http://www.ikerbasque.net/sites/default/files/files/Ikerbasque_RF_2019_Call_Specifications.pdf



*Contact:* Please submit your application for the postdoctoral position
through the Centre’s website (http://biofisika.org/contact/) indicating the
following subject: *Job Application: 52Albesa*, and adding a cover letter,
curriculum vitae, and contact information for three professional referees.
Informal enquires can be directed to davidalb...@gmail.com. Women are
encouraged to apply.



==
David Albesa-Jové, Ph.D.
Ikerbasque Research Associate
Head of the Structural Microbiology Laboratory
Instituto Biofísika (CSIC-UPV/EHU)
Scientific Park of the University of the Basque Country
Barrio Sarriena s/n, 48940 Leioa
SPAIN
Tel – office: +34 94 601 5171
Tel – lab:  +34 94 601 3356
http://www.researcherid.com/rid/F-5683-2016



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[ccp4bb] Postdoctoral Position Available at Rutgers University

[Matthew Neiditch]

An NIH-funded postdoctoral position is available at Rutgers University - New 
Jersey Medical School to study the structural basis of bacterial competence, 
more specifically the movement of DNA across bacterial membranes during natural 
transformation. In addition to a recent Ph.D., the ideal candidate will have a 
strong background in macromolecular X-ray crystallography, cryoEM, 
biochemistry, protein purification, and molecular biology. A working knowledge 
of bacterial genetics is a plus. Candidates with demonstrated success in 
another field and a strong commitment to learning X-ray crystallography and 
cryoEM will also be considered. Please submit: CV and at least 2 letters of 
reference to matthew.neidi...@rutgers.edu and dubna...@njms.rutgers.edu with 
the subject line Postdoctoral Position Applicant.

Matthew B. Neiditch, Ph.D.
Associate Professor
Dept. of Microbiology and Molecular Genetics
New Jersey Medical School
Rutgers University

David Dubnau, Ph.D.
Professor
Public Health Research Institute
New Jersey Medical School
Rutgers University



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[ccp4bb] Postdoctoral position available @EMBL Hamburg

[Margret Fischer]

Dear all,

we are currently looking for a highly motivated molecular biologist with 
protein biochemistry expertise to develop the use of single domain 
antibodies as a platform technology for structural and functional studies
at the EMBL Hamburg unit. The research portfolio of the Hamburg Unit is 
mainly focused on structures of membrane proteins and large protein 
complexes by diverse structural biology approaches including X-ray
crystallography and cryo-electron microscopy. The successful candidate 
will work in a collaborative environment together with structural and 
computational biologists. You will be affiliated with the research group 
of Christian Löw.
The Löw laboratory is specialized in structural biology of integral 
membrane proteins. The team uses innovative approaches to study the 
structure and dynamics of nutrient uptake systems.


Further information about the position can be obtained under the 
following link:http://s.embl.org/HH00169


best

Margret
--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Postdoctoral position available

[Shaun Olsen]

Dear Colleagues,
 
A postdoctoral position is available for a highly motivated 
biochemist/structural biologist interested in studying molecular mechanisms of 
cell signaling by ubiquitin and ubiquitin-like proteins.  Available projects in 
the laboratory provide excellent training opportunities as they involve a 
multidisciplinary approach that combines X-ray crystallography, cryo-electron 
microscopy, biochemical/biophysical techniques, and cell-based assays.

Candidates should hold a recently obtained PhD in structural biology, 
biochemistry, or a related area and should be skilled in standard molecular 
biology techniques and recombinant protein expression and purification.  
Candidates with demonstrated expertise in X-ray crystallography and/or single 
particle cryo-electron microscopy are preferred.

Interested candidates should e-mail a cover letter, CV, and the names of three 
references to olse...@musc.edu.  The position will remain open until filled.
 
Best Regards,

Shaun K. Olsen, PhD
Assistant Professor
Dept. of Biochemistry & Molecular Biology
Medical University of South Carolina
Charleston, SC 29425
olse...@musc.edu



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[ccp4bb] Postdoctoral Position Available at Rutgers University

[Matthew Neiditch]

An NIH-funded postdoctoral position is available at Rutgers University - New 
Jersey Medical School to study the structural basis of bacterial competence, 
more specifically the movement of DNA across bacterial membranes during natural 
transformation. In addition to a recent Ph.D., the ideal candidate will have a 
strong background in macromolecular X-ray crystallography, cryoEM, 
biochemistry, protein purification, and molecular biology. A working knowledge 
of bacterial genetics is a plus. Candidates with demonstrated success in 
another field and a strong commitment to learning X-ray crystallography and 
cryoEM will also be considered. Please submit: CV and at least 2 letters of 
reference to matthew.neidi...@rutgers.edu and dubna...@njms.rutgers.edu with 
the subject line Postdoctoral Position Applicant.

Matthew B. Neiditch, Ph.D.
Associate Professor
Dept. of Microbiology and Molecular Genetics
New Jersey Medical School
Rutgers University

David Dubnau, Ph.D.
Professor
Public Health Research Institute
New Jersey Medical School
Rutgers University



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[ccp4bb] Postdoctoral Position Available

[Andrew Lovering]

Dear All,

A Wellcome-Trust postdoctoral position (for 2 years, possibly extendible to 4) 
is open in the Lovering laboratory, using x-ray crystallography to study the 
means by which predatory bacteria can form a pore in the prey outer membrane.

The link for the position is https://bit.ly/2EET1ta

More information on the lab can be found here: 
https://www.birmingham.ac.uk/staff/profiles/biosciences/lovering-andrew.aspx

Have a good xmas!
Andy



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[ccp4bb] Postdoctoral position available at Structural Biology Unit, IBMB-CSIC, Barcelona

[Laia Vives Adrián]

Dear all,

a 3-year postdoctoral position at the Structural Biology Unit (IBMB-CSIC,
Barcelona) is available.

Find all the information at the following link
:

https://sbu.csic.es/jobs/postdoctoral-position-gomis-ruth-2018/

Please distribute to anyone who may be interested.

Laia Vives Adrián
Project Manager & Head of Communication

Structural Biology Unit (IBMB-CSIC)
Parc Científic de Barcelona
c/Baldiri Reixac, 15 08028 Barcelona
Tel: 934020189

www.sbu.csic.es
 @sbu_csic 
 Structural Biology Unit CSIC




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[ccp4bb] postdoctoral position available in Australia

[Forwood, Jade]

Dear CCP4 BB Members,

We have a two year postdoctoral position in Australia. The start date can be 
anytime from now. The work will involve protein expression, purification, 
crystallisation, and structure determination of protein-protein complexes. For 
specific details on the project and/or work environment, please email 
jforw...@csu.edu.au

Best,

Jade.

Prof Jade Forwood
ARC Future Fellow
School of Biomedical Sciences
Charles Sturt University
Wagga Wagga 2650
Australia
Ph: +61 2 693 32317
Fx:  +61 2 693 32587
http://csusap.csu.edu.au/~jforwood/




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[ccp4bb] Postdoctoral Position available - University of Warsaw, Poland

[Paulina Dominiak]

Dear colleagues,

I would like to draw your attention to a post-doctoral position 
available in my research group.

For all the details, please see the complete call text below.
If you need any further information, please contact me directly.

Best regards,
Paulina Dominiak


An announcement for Post-doctoral position

Position of Post-doctoral Researcher in the OPUS project entitled

"More accurate models of the electrostatic potential of biological 
macromolecules and organic crystals necessary for proper interpretation 
of data from cryo-electron microscopy and from electron diffraction – 
feasibility study"


financed by NCN is open for application.

Project leader: dr hab. Paulina M. Dominiak, prof. UW

Available positions: 1

Project description:
The Dominiak’s group works on developing new methods of electron density 
modelling for X-ray and electron crystallography, chemistry and 
structural biology. The project aims at development of new models of 
electrostatic potentials for electron crystallography. The models will 
considerably deviate from the conventional spherical independent atom 
model currently used. With new models more  information should be 
extracted from electron scattering experiments on biological 
macromolecules and organic crystals, and improved quality of geometric 
data and quantitative estimates of molecular electrostatic potentials 
should become easily available. For further information see 
http://cnbch.uw.edu.pl and http://www.chem.uw.edu.pl.


Position description:
You will be mainly responsible for development and verification of new 
databanks of atomic electron densities on the basis of existing procures 
published in: Acta Cryst. 2012, A68, 139; JCTC, 2014, 10, 1652; 
ChemPhysChem, 2016, 17, 2455; Acta Cryst. 2017, B73, 610.


We are looking for motivated candidates with:

-a PhD degree in chemistry or related fields at the moment of starting 
the job (PhD defended not later than 7 years ago according to NCN 
regulations, see www.ncn.gov.pl)
-experience in crystallography OR/AND computational chemistry proven by 
scientific article publications
-knowledge of macromolecular crystallography OR/AND proven experience in 
high-resolution x-ray diffraction charge density measurements
-basic programing skills OR/AND practical experience in script 
usage/writing and proven ability to work with large amount of data
-experience with structure refinement against electron diffraction or 
single particle cryoEM data will be an advantage

-well-developed analytical skills
-good knowledge of written and spoken English
-written and spoken presentation skills
-ability to work as part of a team
We offer:
a temporary employment contract with the University of Warsaw:
-full time position
-a salary approx. 5000 PLN per month (net salary, after taxes and other 
deductions)

-for one year with a possible extension upto three years
-appointment starting in November 2018 (the competition may be repeated 
until a suitable candidate who fulfils all requirements is found)


Required documents (in English):
-Curriculum Vitae (including list of scientific articles, conference 
presentations, awards, international internships,  scholarships, 
workshops, participation in research projects),
-a motivation letter (What are your scientific interests? What are your 
key strengths and achievements? Why do you want to work in the project?),

-information on the processing of personal data (see the text below),
-two recommendation letters (at least one from direct supervisor) sent 
by the referees directly  to prof. Dominiak (pdo...@chem.uw.edu.pl).


Please submit the documents no later than 26 October 2018 to: 
pdo...@chem.uw.edu.pl (PDF is the preferred format). E-mail entitled: 
“Post-Doc position”


Selected candidates may be invited by e-mail, no later than  30 October 
2018, to participate in interview.  The interview will take place on 5 
or 6 November 2018 in person or via Skype or phone. The results of the 
competition will be delivered to selected candidates by e-mail till 15 
November 2018. In the case of not signing the contract by the candidate, 
due to the resignation, we reserve the right to choose the next 
candidate from the ranking list.


 
INFORMATION ON THE PROCESSING OF PERSONAL DATA
INFORMATION CLAUSE
Pursuant to Article 13 of Regulation (EU) 2016/679 of the European 
Parliament and of the Council of 27 April 2016 on the protection of 
natural persons with regard to the processing of personal data and on 
the free movement of such data, and repealing Directive 95/46/EC 
(General Data Protection Regulation), University of Warsaw hereby informs:
1.	The Controller of your personal data is the University of Warsaw with 
its registered office at Krakowskie Przedmieście 26/28, 00-927 Warszawa;
2.	The Controller has designated the Data Protection Officer who 
supervises the processing of personal data, and who can be contacted via 
the following e-mail address: i...@adm.uw.edu.pl;
3.	

[ccp4bb] postdoctoral position available

[Elisa BERGAMIN]

Two years full time postdoctoral position available in the laboratory of Elisa 
Bergamin, PhD., at the Institute of Genetic and Molecular and Cellular Biology 
(IGBMC) in Illkirch-Graffenstaden, near Strasbourg, in France. 
We use a combination of cryo-electron microscopy, X-ray crystallography, 
biochemistry, and other functional assays to study the molecular mechanisms of 
action of the mammalian SWI/SNF protein complex with special attention to newly 
identified subunits.
We welcome highly qualified and motivated individuals with a Ph.D. training in 
structural biology (cryo-electron microscopy, X-ray crystallography) and/or 
protein biochemistry. 
The ideal applicant will have experience with protein crystallography and 
cryoEM, molecular biology, and protein complex expression and purification. 
Although not a strict requirement, preference will be given to candidates with 
experience in single particle Cryo-EM. The position might also be of interest 
to people with experience in other structural biology areas (crystallography, 
NMR, computational modelling) that are eager to learn cryo-EM.
The IGBMC is a leading European research institute focused on understanding 
human disease and basic biological mechanisms at the molecular level. It counts 
several state-of-the-art technical facilities including the Titan Krios cryo 
electron microscope and a high throughput crystallization facility. It is a 
vibrant, international scientific community.
Please send your application (as a single pdf document) including cover letter, 
brief statement of prior research experience, a one-page statement of current 
research goals, CV, and contact information for three references to: 
berga...@igbmc.fr



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

[ccp4bb] Postdoctoral position available

[Daniel Rosenbaum]

Dear all,

A postdoc position is available in my lab. I am looking for someone with 
experience in protein biochemistry and structural biology who is interested in 
studying the structure and mechanism of GPCRs. Project will involve elucidating 
mechanisms of activation and inhibition of therapeutically important CNS 
receptors, in collaboration with chemical biology collaborators. X-ray 
crystallography is a central technique in the lab, however we also use other 
biophysical techniques including cryo-EM and NMR.

Send CV to 
dan.rosenb...@utsouthwestern.edu, or 
contact me for more information.

Best,
Dan

—
Daniel Rosenbaum
Associate Professor
UT Southwestern
Dept. of Biophysics




UT Southwestern


Medical Center



The future of medicine, today.




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[ccp4bb] Postdoctoral position available

[Guenter Fritz]

Dear all,

a postdoctoral position is available in a joint project between my group 
and the group of Julia Fritz-Steuber. The position is at the University 
of Stuttgart Hohenheim, where I have moved recently. The position is 
available immediately with preferred starting date 1.1.2018.


The project is on a membrane protein complex and its maturing factors 
(https://www.nature.com/articles/nature14003). A successful candidate is 
experienced in (membrane) protein biochemistry, biochemistry of oxygen 
sensitive proteins (work with a glove box) and X-ray crystallography.


Applications should be send to guenter.fr...@uni-hohenheim.de.

Please contact me for any further information.

Best regards,

Guenter Fritz

[ccp4bb] Postdoctoral Position available - Long Island, New York

[Steven Glynn]

A postdoctoral position is available in the laboratory of Dr. Steven Glynn
at Stony Brook University (*https://you.stonybrook.edu/glynnlab
*). We are looking for a highly
motivated individual to participate in a collaborative research project to
determine the structure and mechanism of proteases that regulate protein
quality control in mitochondria.



https://www.nature.com/articles/ncomms13301

https://www.ncbi.nlm.nih.gov/pubmed/28214511

https://www.biorxiv.org/content/early/2017/09/15/189316



The candidate should hold a Ph. D in Biochemistry, Structural Biology or
related field in hand by January 1, 2018. Qualified applicants will have
demonstrated experience in molecular biology, and protein expression and
purification. Experience in protein structure determination, enzyme
activity assays, and yeast protein expression is preferred.



The Glynn Lab is located at Stony Brook University, 60 miles from New York
City on Long Island's scenic North Shore. We have access to state of the
art facilities in enzymology and structural biology, including the nearby
National Synchrotron Light Source II.  The 1,100-acre campus is home to
24,000 undergraduate, graduate, and doctoral students and more than 13,500
faculty and staff, including those employed at Stony Brook Medicine.



Interested applicants should apply at:

https://stonybrooku.taleo.net/careersection/jobdetail.ftl?job=1700692=GMT-04:00=en



or by visiting http://www.stonybrook.edu/hr/prospective-employees.shtml and
applying to position *1700692*



The posting is available until October 31st. Inquiries may be sent to
steven.gl...@stonybrook.edu

-- 
Steven E. Glynn, PhD
Assistant Professor
Department of Biochemistry and Cell Biology
Stony Brook University
148 Centers for Molecular Medicine
Stony Brook, NY 11794-5115
Tel: 631-632-1055

[ccp4bb] Postdoctoral Position available at The Institute of Cancer Research, London UK

[Rob Van Montfort]

The Institute of Cancer Research, London, is one of the world’s most 
influential cancer research institutes, with an outstanding record of 
achievement dating back more than 100 years. We provided the first convincing 
evidence that DNA damage is the basic cause of cancer, laying the foundation 
for the now universally accepted idea that cancer is a genetic disease. Today, 
The Institute of Cancer Research (ICR) leads the world at isolating 
cancer-related genes and discovering new targeted drugs for personalised cancer 
treatment. Under the leadership of our Chief Executive, Professor Paul Workman 
FRS, the ICR is ranked as the UK’s leading academic research centre. Together 
with our partner The Royal Marsden, we are rated in the top four cancer centres 
globally. The ICR is committed to attracting, developing and retaining the best 
minds in the world to join us in our mission – to make the discoveries that 
defeat cancer.
The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of 
Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, 
comprising around 160 staff dedicated to the discovery and development of novel 
therapeutics for the treatment of cancer. The Cancer Therapeutics Unit’s 
exciting goal is to discover high quality small molecule drug candidates and to 
progress these to clinical trial. All the scientific disciplines are in place 
to make this possible, including medicinal chemistry, biology, drug metabolism 
and clinical specialists who focus on new molecular targets emerging from human 
genome and ground breaking cell biology research.

A postdoctoral position is available in Dr Rob van Montfort’s Hit Discovery and 
Structural Design Team within the CTU. The Post-doc will be involved in 
high-throughput X-ray crystallography, fragment-based screening and 
structure-based drug design and will be responsible for protein expression, 
purification, crystallisation, structure determination and structural analysis 
of protein-ligand complexes from one of the CTU’s drug discovery programmes. 
The successful candidate will also be part of the Division of Structural 
Biology, in which the crystallographers in Dr van Montfort’s team are embedded, 
and will have access to state of the art crystallisation facilities, in-house 
X-ray sources and excellent access to synchrotrons. The successful candidate 
will interact closely with the biology, computational chemistry and medicinal 
chemistry teams at the CTU, and will therefore be expected to work across the 
two sites in Chelsea, London and Sutton, Surrey.

Applicants must have a PhD in a biological or physical science, and experience 
in macromolecular crystallography (to include protein biochemistry, protein 
crystallisation, & protein crystallography). Experience in molecular biology, 
protein expression in insect cells, structure-based drug design, and/or 
biophysics will be an advantage.

The starting salary will be in the range £30,410 to £37,383 p.a. inclusive 
(based on previous post-doctoral experience) and the post is offered on a fixed 
term contract of 2 years. Informal enquiries to 
rob.vanmontf...@icr.ac.uk or 
yann-vai.lebi...@icr.ac.uk. Closing date is 
November 21st 2017.

Please DO NOT send your application to Dr van Montfort or Dr Le Bihan; Please 
see our website for more details and on how to apply: 
www.icr.ac.uk.

Dr. Rob van Montfort
Team Leader Hit Discovery and Structural Design
Divisions of Cancer Therapeutics and Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG
UK

Tel:
+44-(0)20-8722-4364 (Sutton)
+44-(0)20-7153-5142 (Chelsea)
Email: rob.vanmontf...@icr.ac.uk








The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company 
Limited by Guarantee, Registered in England under Company No. 534147 with its 
Registered Office at 123 Old Brompton Road, London SW7 3RP.

This e-mail message is confidential and for use by the addressee only.  If the 
message is received by anyone other than the addressee, please return the 
message to the sender by replying to it and then delete the message from your 
computer and network.

[ccp4bb] postdoctoral position available

[Jeffrey B Bonanno]

I would like to draw your attention to a position available in New York City:

The laboratories of Kartik Chandran and Steve Almo at the Albert Einstein 
College of Medicine seek a highly motivated and innovative post-doctoral 
scientist interested in the structural, mechanistic and functional analysis of 
viral entry mechanisms exploited by New World and Old World Hantaviruses, and 
newly discovered emerging viruses. Albert Einstein offers a unique environment 
for these studies, including high-throughput resources for protein 
purification, biochemical studies, and high resolution structural analyses. 
Successful candidates must have demonstrated considerable expertise in protein 
chemistry and structural biology. This position requires a significant level of 
independence, as well as the ability to interface with a larger team of 
investigators, and will afford freedom in defining future courses of study.
 
Applicants must have a PhD, MD, or equivalent degree. Qualified applicants 
should submit a cover letter, curriculum vitae, and a brief summary of research 
accomplishments and goals in a single PDF document to steve.almo  
einstein.yu.edu. Applicants should also arrange to have three letters of 
reference sent directly to this email address.
 
cheers,
Jeff

Jeffrey Bonanno, Ph.D.
Department of Biochemistry
Albert Einstein College of Medicine
1300 Morris Park Avenue
Bronx, NY 10461
718-430-2452
jeffrey.bona...@einstein.yu.edu

[ccp4bb] Postdoctoral Position available, IHV of University of Maryland, Baltimore, MD

[Pazgier, Marzena]

A postdoctoral position is available immediately to participate in an 
inter-disciplinary research program on structural immunology at the Institute 
of Human Virology of School of Medicine, University of Maryland, Baltimore, MD. 
Candidates are expected to work on ongoing research projects in structural 
biology aimed at understanding Fc mediated effector function of antibodies to 
HIV-1 and development of antibody-based therapeutics and novel vaccine 
concepts. Qualifications for the position include: strong research interest and 
experience in cell biology, functional analyses, biophysical and structural 
techniques (which may include a combination of: X-ray crystallography, 
computational chemistry, small-angle X-ray scattering and cryoEM) and excellent 
interpersonal/oral/written communication skills. Candidates need to be highly 
motivated individuals who enjoy working as part of a young, dynamic, 
collaborative and multidisciplinary team. Preference will be given to 
candidates with exceptionally strong experimental skills, a strong record of 
peer-reviewed publications and with experience in small-angle X-ray scattering 
and/or CryEM image reconstruction. Qualified candidates should have a doctorate 
in in the field of structural biology, biochemistry or immunology. New Ph.D. 
graduates are highly encouraged to apply.



Interested candidates should send a CV, one page research experience summary 
and contact information for three references to mpazg...@ihv.umaryland.edu. 
Salary and starting date are negotiable.



The University of Maryland, Baltimore is an Equal Opportunity/Affirmative 
Action Employer.  Minorities, women, veterans and individuals with disabilities 
are encouraged to apply.

[ccp4bb] Postdoctoral Position available, IHV of University of Maryland, Baltimore, MD

[Pazgier, Marzena]

A postdoctoral position is available immediately to participate in an 
inter-disciplinary research program on structural immunology at the Institute 
of Human Virology of School of Medicine, University of Maryland, Baltimore, MD. 
Candidates are expected to work on ongoing research projects in structural 
biology aimed at understanding Fc mediated effector function of antibodies to 
HIV-1 and development of antibody-based therapeutics and novel vaccine 
concepts. Qualifications for the position include: strong research interest and 
experience in cell biology, functional analyses, biophysical and structural 
techniques (which may include a combination of: X-ray crystallography, 
computational chemistry, small-angle X-ray scattering and cryoEM) and excellent 
interpersonal/oral/written communication skills. Candidates need to be highly 
motivated individuals who enjoy working as part of a young, dynamic, 
collaborative and multidisciplinary team. Preference will be given to 
candidates with exceptionally strong experimental skills, a strong record of 
peer-reviewed publications and with experience in small-angle X-ray scattering 
and/or CryEM image reconstruction. Qualified candidates should have a doctorate 
in in the field of structural biology, biochemistry or immunology. New Ph.D. 
graduates are highly encouraged to apply.

Interested candidates should send a CV, one page research experience summary 
and contact information for three references to mpazg...@ihv.umaryland.edu. 
Salary and starting date are negotiable.

The University of Maryland, Baltimore is an Equal Opportunity/Affirmative 
Action Employer.  Minorities, women, veterans and individuals with disabilities 
are encouraged to apply.

[ccp4bb] Postdoctoral Position available at The Institute of Cancer Research, London UK

[Rob Van Montfort]

The Institute of Cancer Research, London, is one of the world’s most 
influential cancer research institutes, with an outstanding record of 
achievement dating back more than 100 years. We provided the first convincing 
evidence that DNA damage is the basic cause of cancer, laying the foundation 
for the now universally accepted idea that cancer is a genetic disease. Today, 
The Institute of Cancer Research (ICR) leads the world at isolating 
cancer-related genes and discovering new targeted drugs for personalised cancer 
treatment. Under the leadership of our Chief Executive, Professor Paul Workman 
FMedSci, the ICR is ranked as the UK’s leading academic research centre. 
Together with our partner The Royal Marsden, we are rated in the top four 
cancer centres globally.The ICR is committed to attracting, developing and 
retaining the best minds in the world to join us in our mission – to make the 
discoveries that defeat cancer.
The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of 
Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, 
comprising around 160 staff dedicated to the discovery and development of novel 
therapeutics for the treatment of cancer. The Cancer Therapeutics Unit’s 
exciting goal is to discover high quality small molecule drug candidates and to 
progress these to clinical trial. All the scientific disciplines are in place 
to make this possible, including medicinal chemistry, biology, drug metabolism 
and clinical specialists who focus on new molecular targets emerging from human 
genome and ground breaking cell biology research.
A postdoctoral position is now available in the Hit Discovery and Structural 
Design Team within the CTU (Ref. 1646606). The team combines assay development 
and small-molecule high-throughput screening with fragment-based hit discovery, 
biophysical assays and X-ray crystallography. These methodologies are 
underpinned by state-of-the art protein expression, purification and protein 
characterisation capabilities allowing the generation of large quantities of 
high quality recombinant proteins. The successful candidate will work on an 
exciting early stage target in CTU’s drug discovery portfolio. The postdoctoral 
training fellow will establish the successful expression, purification and 
characterisation of the protein target, using contemporary expression systems, 
including insect and mammalian cells, and purification methods available within 
the team. They will establish the in-house crystallisation and structure 
determination and subsequently carry out the structural determination of 
protein-inhibitor complexes. In addition, the post-holder is expected to 
initiate the development of biochemical and biophysical assays to characterise 
the protein target and to establish compound screening assays. The successful 
candidate will be an integral member of a multidisciplinary project team and 
will interact closely with the biologists, computational chemists, medicinal 
chemists and structural biologists and will therefore be expected to work 
across the two sites in Chelsea, London and Sutton, Surrey.
Applicants must have a PhD in a biological or physical science, and experience 
in macromolecular crystallography (to include protein biochemistry, protein 
crystallisation, & protein crystallography). Experience in insect 
cell/mammalian cell expression, assay development, and/or biophysics will be 
highly advantageous. The starting salary for this position will be up to 
£35,538p.a. inclusive (based on previous experience) and the post is offered on 
a fixed term contract of 1 year.
Further information about these positions can be found in the full job 
description at www.icr.ac.uk. Informal enquiries to 
rob.vanmontf...@icr.ac.uk - but applications 
must be submitted on-line (www.icr.ac.uk). Closing date 
is June 11th.

Dr. Rob van Montfort
Team Leader Hit Discovery and Structural Design
Joint Interim Head of Division of Structural Biology
Divisions of Cancer Therapeutics and Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG
UK

Tel:
+44-(0)20-8722-4364 (Sutton)
+44-(0)20-7153-5142 (Chelsea)
Email: rob.vanmontf...@icr.ac.uk







The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company 
Limited by Guarantee, Registered in England under Company No. 534147 with its 
Registered Office at 123 Old Brompton Road, London SW7 3RP.

This e-mail message is confidential and for use by the addressee only.  If the 
message is received by anyone other than the addressee, please return the 
message to the sender by replying to it and then delete the message from your 
computer and network.

[ccp4bb] postdoctoral position available

[Tom Peat]

Dear Board Readers,

For anyone who might be interested, or know of interested persons, there is a 
postdoctoral position available at CSIRO:

https://career10.successfactors.com/sfcareer/jobreqcareer?jobId=39270=CSIRO

Best regards,  tom

[ccp4bb] Postdoctoral Position Available to Study Structure and Mechanisms of Gene-regulatory Noncoding RNAs and Highly Structured Viral RNAs

[Jinwei Zhang]

A fully funded postdoctoral position (up to 5 years) is available in the 
Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory 
of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD 
near Washington DC. The lab addresses a widening gap between the accelerated 
discovery and functional description of the noncoding transcriptome, and a 
paucity of 3D structures and mechanistic understanding of complex noncoding 
RNAs. We seek a new member to join our diverse group to deepen current work on 
gene-regulatory riboswitches, highly structured viral RNAs, circular and other 
structured long noncoding RNAs. 
https://www-mslmb.niddk.nih.gov/zhang/zhanglab.html


Current manuscripts and recent publications:
1. Li et al., & Zhang (2017) Structural basis of amino acid sensing on the tRNA 
by a T-box riboswitch. In preparation.

2. Bahmanjah et al., & Zhang (2017) Structural basis of functional repurposing 
of an aminoacyl-tRNA synthetase in stress response. In preparation.

3. Hood et al., & Zhang (2017) Structural mimicry of codon-anticodon 
interactions by a viral noncoding RNA. In preparation.

4. Zhang & Ferré-D'Amaré (2014) Dramatic improvement of crystals of large RNA 
by cation replacement and dehydration. Structure 22, 1363-1371.

5. Zhang & Ferré-D'Amaré (2014) Direct evaluation of tRNA aminoacylation status 
by the T-box riboswitch using tRNA-mRNA stacking and steric readout. Molecular 
Cell 55, 148-155.

6. Zhang & Ferré-D'Amaré (2013) Co-crystal structure of a T-box riboswitch stem 
I domain in complex with its cognate tRNA. Nature 500, 363-7.


The lab is part of the Earl Stadtman Investigator program for high-risk, 
high-impact research at the NIH intramural program consisting of 1100 labs. The 
well-supported lab has dedicated access to state-of-the-art equipment in 
structural biology (Mosquito, Dragonfly, Rock Imager, Akta Pures, FSEC, for 
X-ray crystallography; new Titan Krios for single-particle Cryo-EM; SAXS, AFM, 
etc), efficient biochemistry, biophysics (ITC, DSC, SPR, BLI, AUC, DLS, 
SEC-MALS, CD, fluorescence, thermophoresis, etc), fermentation, genomics, and 
proteomics core facilities with hands-on training or service by PhD-level staff 
scientists. The NIH, NIDDK, and LMB are committed to the continued education 
and career development of trainees through numerous courses and workshops 
offered by NIH OITE and FAES. 

Requirements: Interested candidates must have received (or be expecting) a 
Ph.D. or M.D. within the past five years in molecular or structural biology, 
biochemistry, or biophysics, and be strongly self-motivated to lead innovative 
and rigorous research projects. Strong background in protein expression and 
purification, enzyme kinetics, and structural biology is desirable. 

To apply: Please email a preferred start date, CV, a brief summary of research 
interests, accomplishments, and career goals, and names and contact information 
for at least three references to: Dr. Jinwei Zhang, Email: 
jinwei.zh...@nih.gov. The NIH is dedicated to building a diverse community and 
DHHS/NIH is an Equal Opportunity Employer.

[ccp4bb] Postdoctoral Position available - Birkbeck - Gabriel Waksman

[Gabriel Waksman]

Postdoctoral position available to work in Professor Gabriel Waksman’s 
laboratory. See detail below:

http://jobs.bbk.ac.uk/fe/tpl_birkbeckcollege01.asp?s=4A515F4E5A565B1A=62907,6135151214=109009471=72867758720287=seryeckcebralfkhmw
 

[ccp4bb] Postdoctoral position available

[Kim, Jung Ja]

A postdoctoral position is immediately available in the laboratory of Dr. 
Jung-Ja Kim at the Department of Biochemistry, Medical College of Wisconsin, 
Milwaukee, WI.  The project entails an interdisciplinary approach to studying 
the catalytic mechanisms of cytochrome P450 reductase and nitric oxide synthase 
isozymes, using various biophysical techniques, including time-resolved 
structure/function studies in solution and time-resolved crystallography.  This 
is a collaborative project under the NSF Program International Collaboration 
in Chemistry between US NSF and French ANR.  Applications are invited from 
candidates with prior experience in protein X-ray crystallography, with strong 
background in protein biochemistry and enzymology. Preference will be given to 
candidates who received their Ph.D. degree recently.
For more information on the Kim laboratory research, please visit  
http://www.mcw.edu/biochemistry/faculty/JungJaKim.htm
Interested applicants should submit their CV, publication record, and contact 
information of three references to:  Interested candidates should send their 
CV, brief description of prior research accomplishments and contact information 
for three references to Jung-Ja Kim (jj...@mcw.edumailto:jj...@mcw.edu).
Jung-Ja Kim, Ph.D.
Professor
Department of Biochemistry
Medical College of Wisconsin
Milwaukee, WI 53226

[ccp4bb] Postdoctoral position available in structural virology

[Frank Li]

Applications are invited for a postdoctoral position in Dr. Fang Li's 
lab at the Department of Pharmacology, University of Minnesota Twin 
Cities. Research involves biochemical and structural studies of proteins
 that guide invasion and replication of viral pathogens.



Strong background in molecular biology and protein biochemistry is 
required. Experience in insect cell culture and protein crystallography 
is preferred. Candidates must have completed PhD at the time of the 
appointment. Salary commensurates with experience. The position starts 
immediately. For more information about Dr. Li's lab, visit 
http://www.msi.umn.edu/~lifang/.



Interested applicants should send (1) a resume, (2) a one-page summary 
of previous research experience, and (3) arrange two letters of 
recommendation to be sent to Dr. Fang Li via email (lif...@umn.edu).
  

[ccp4bb] Postdoctoral position available - Molecular Biology-Biochemistry - University of Minnesota

[Mikael Elias]

A new and exciting postdoc position is available at the University of
Minnesota, USA, Department of Biochemistry, Molecular Biology, and
Biophysics, in the Lab of Mikael Elias (http://www.cbs.umn.edu/lab/elias). 

The project scope relate to the cellular phosphate and phosphonate uptake
mechanisms, a very central cellular mechanism that modulates numerous
cellular responses, from quorum sensing to bacterial virulence. The project
will involve a significant variety of methods, including state-of-the-art
molecular biology, biochemistry, structural biology and bioinformatics.

The Fellow will join a highly stimulating environment, working in the
BioTechnology Institute, and will have outstanding opportunities on a
research projects with numerous possible applications. The candidate should
hold a PhD thesis in Biochemistry, Molecular biology, Structural Biology or
related areas. The fellow should be a passionate and skilled molecular
biologist and biochemist.  

Environment: The University of Minnesota, founded in 1851, is one of the
largest university in the United States, and ranks amongst the most
prestigious research universities in the world. The campus is located in the
heart of the Minneapolis-St Paul (Twin Cities) area, an enjoyable,
affordable place, extremely rich in cultural events and natural attractions.

The University of Minnesota is an equal opportunity educator and employer.

To apply, please send a CV and names for at least two referees to Mikael
Elias: mhel...@umn.edu mailto:mhel...@umn.edu 

 

[ccp4bb] Aw: Re: [ccp4bb] postdoctoral position available

[nicola horstmann]

Dear Ccp4 user,




on behalf of Dr. Muthiah Kumaraswami I would like to inform you that

there is a postdoc position available in the Department of Pathology and Genomic Medicine

at the Houston Methodist Hospital Research Institute.



The group employs a multidisciplinary approach to dissect the mechanisms of bacterial signaling

pathways and to understand the implications of such signaling pathways in bacterial pathogenisis.

Key areas the group is currently investigating include bacterial communication systems and the bacterial

sensory systems for metal and carbohydrate acquisiton.

To this end, we are using a wide range of techniques including X-ray crystallography, SAXS, bacterial genetics,

biochemical and transcriptome analyses, and animal infection studies.



Qualifications and Experience:

Qualified candidates will have or are about to obtain a PhD degree. Candidates are expected to have experience

in protein biochemistry and crystallography. Experience in MAD phasing and model building as well as biochemical/

analytical techniques are a plus. The ability to work in a team, good organizational and communication skills in

English as well as initiative, flexibility and good learing ability are also desired.



Applicants should send a CV with description of current and future research interests, pdfs of representative publications,

and the names, addresses, phone number and e-mail addresses of 2-3 references to

mkumarasw...@houstonmethodist.org





Best wishes,

Nicola




Gesendet:Montag, 02. Mrz 2015 um 05:49 Uhr
Von:Avisek Mondal avisekmonda...@gmail.com
An:CCP4BB@JISCMAIL.AC.UK
Betreff:Re: [ccp4bb] substructure solution.


Thank you all for the guidance.


Avisek



On Mon, Mar 2, 2015 at 4:24 PM, Tim Gruene t...@shelx.uni-ac.gwdg.de wrote:

Dear Avisek,

did you try shelxd for substructure solution? I think that it tries to
avoid the Uranium solution. There are a couple of caveats with soaks,
e.g. you are not sure about the number of sites and their occupancies.
Occupancies are refined by shelxd, and you can test a few number of
search sites - shelxd has a certain tolerance with respect to the number
of sites. Do you have a native data set, too? Maybe you could try SIRAS
instead of SAD for better phases?

If you feel unfamiliar with shelxc / shelxd shelxe , you can use the GUI
through ccp4i, or also hkl2map which guide you through the process.

Note that autotracing may not work well at 3A resolution.

Best regards,
Tim


On 02/23/2015 02:29 PM, Avisek Mondal wrote:
 Dear all,
 I am trying to phase a large novel structure of 150 kDa with P21 space
 group. So far I have collected 3.0A datasets from iodinated derivatives in
 Cu-K alpha. In SAD phasing I got 0.745 figure of merit (FOM) and LLG about
 476208.27 (sites in inverse hand gave the same FOM and LLG),by Phenix
 Phaser-EP. But i am seeing monstrous peak from the substructure solution,
 it seems that all phases merge into huge fourier peak (like Urenium-atom
 solution and Fourier truncation ripples; Ref.Bernerd and Rupp) .But it is
 clear that the iodine has incorporated into the proteins lysine residues
 where the large electron density has been seen (from partial molecular
 replacement solution). Would anyone be able to advise me on how itd be
 best to improve my phases/density given the limitations of the data? it
 will be very helpful for me as a learner.

 Avisek



--
Dr Tim Gruene
Institut fuer anorganische Chemie
Tammannstr. 4
D-37077 Goettingen

GPG Key ID = A46BEE1A

[ccp4bb] Postdoctoral position available at UT Southwestern Medical Center at Dallas

[Hong Zhang]

A postdoctoral researcher position has just become available in Dr. Hong 
Zhang’s laboratory to study mammalian circadian clocks. The overall goal of the 
project is to understand how various multi-domain clock proteins interact with 
each other; and how these interactions are modulated to regulate the 
clock-mediated transcription activation. A number of multi-protein complexes 
have been over-expressed, reconstituted, and purified for crystallization 
experiments. We are looking for a highly motivated postdoctoral fellow with a 
Ph.D. degree in a relevant field. He or she should be proficient in molecular 
cloning, protein expression, purification, crystallization, and X-ray crystal 
structure determination. Additional experiences in insect cell protein 
expression systems and various biochemical and biophysical techniques to study 
protein-protein interactions are particularly helpful. 

 

If you are interested in this position, please email your CV and contact info 
of two or more referees to zh...@chop.swmed.edu. 

 

Happy New Year and all the Best!

 

 

Hong Zhang, Ph.D.

Associate Professor

Department of Biophysics and Department of Biochemistry

UT Southwestern Medical Center at Dallas

4323 Harry Hines Blvd.

Dallas, Texas 75390-8816

Phone: 214-645-6372

Fax:   214-645-5948

http://profiles.utsouthwestern.edu/profile/23445/hong-zhang.html

 

 

[ccp4bb] postdoctoral position available

[Collins, Edward J]

POSTDOCTORAL FELLOW POSITION University of North Carolina DEPARTMENT OF 
MICROBIOLOGY AND IMMUNOLOGY

We are seeking a motivated PhD crystallographer to drive two projects dealing 
with host defense against pathogens.  The first project involves peptide 
binding to MHC and is a highly productive collaboration between a computational 
chemist and our lab involving design of HIV therapeutics.  The second project 
is the design and production of therapeutic bi-specific antibodies directed 
against peptide/MHC complexes.  We have already designed and are currently 
testing an antibody directed towards HER2/neu overexpressing tumors.   The 
fellow will be responsible for the crystallography associated with each project 
and can drive the therapeutic antibody project as far as they wish to go.

The position is open immediately and is available for up to four years with 
yearly reappointments.

Biophysicists without direct crystallographic experience will be considered.

Applications will be administered through the department at: 
https://unc.peopleadmin.com/postings/63270
Please include a C.V., cover letter and list of three references.

The cover letter should be directed specifically to  Dr. Edward J Collins and 
specifying that you are applying for this set of projects.

Since the applications on the website go to our department, it would be wise to 
send an email to Dr. Collins once the application is complete.

[ccp4bb] postdoctoral position available in Singapore, Duke-NUS

[Sheemei Lok]

 
Post-doctoral position in Singapore at the Duke-NUS is
available
A post-doctoral position is available at the laboratory of Shee-Mei
Lok (http://www.loksheemeilab.com) in the emerging infectious disease program
of the Duke-NUS. Duke-NUS graduate medical school situated in Singapore, is a
global partnership between Duke University and the National University of
Singapore. We have the state of the art facility for both x-ray crystallography
and also cryoelectron microscopy (Titan Krios with Falcon II detector, Jeol
microscope with phase plate, energy filter and DE camera). Projects
undertaken by the post-doc will mainly investigate the structure and function
of important proteins contributing to the longevity and low rates of cancer in
bats. He/she will also take part in dengue virus research. In addition to
crystallography, cryo-electron microscopy will also be used to determine the
structures. Individuals with experience in electron microscopy and/or 
crystallography,
protein expression and purification are highly desirable. 
Interested individuals should send their CV, experience, research
interest, and a list of three referees to Shee-mei Lok 
(sheemei@duke-nus.edu.sg)

[ccp4bb] Postdoctoral position available in the area of Membrane Transport at Northwestern University

[Heather Pinkett]

Postdoctoral position available in the area of Membrane Transport at
Northwestern University

The Pinkett laboratory at Northwestern University is seeking a highly
motivated candidate for a postdoctoral fellow position in the field of
protein structural biology. The individual will join a  research team
studying the structure and function of ABC transporters.  Our laboratory is
equipped with state-of-the art facilities for structural biology and
protein biochemistry research.  We also have access to nearby Argonne
National labs (APS).

An ideal applicant would be highly motivated with strong analytical skills
and enjoy working independently as well as in a collaborative environment.
A strong background in X-ray crystallography, protein expression and/or
biochemistry is a plus.  The position requires a Ph.D. in a related field
and less than two years of postdoctoral experience.

Applicants should email their CV and a summary of their research experience
to Dr. Heather Pinkett (h-pink...@northwestern.edu).

-- 
Heather W Pinkett, PhD

Assistant Professor
Department of Molecular Biosciences
Northwestern University
2205 Tech Drive
Evanston, IL 60208-3500

Office: Cook Hall 4133
Lab: Cook Hall 4161

Tel. (847) 467-4048
h-pink...@northwestern.edu

-- 
Heather W Pinkett, PhD

Assistant Professor
Department of Molecular Biosciences
Northwestern University
2205 Tech Drive
Evanston, IL 60208-3500

Tel. (847) 467-4048
Office: Cook Hall 4133

Lab: Cook Hall 4161
Tel. (847) 467-0877

h-pink...@northwestern.edu

http://groups.molbiosci.northwestern.edu/pinkett/Pinkettlab/Welcome.html

[ccp4bb] Postdoctoral position available - Molecular Biology-Biochemistry - University of Minnesota

[Mikael Elias]

 

An exciting postdoc position is available at the University of Minnesota,
USA, Department of Biochemistry, Molecular Biology, and Biophysics, in the
Lab of Mikael Elias (http://www.cbs.umn.edu/lab/elias). 

The project scope relate to the cellular phosphate uptake mechanism, a very
central cellular mechanism that modulates numerous cellular responses, from
quorum sensing to bacterial virulence. The project will involve a
significant variety of methods, including state-of-the-art molecular
biology, biochemistry, structural biology and bioinformatics.

The Fellow will join an exciting new Lab, in a highly stimulating
environment, and will have outstanding opportunities. The candidate should
hold a PhD thesis in Biochemistry, Molecular biology, Structural Biology or
related areas. The fellow should be a passionate and skilled molecular
biologist and biochemist.  

Environment: The University of Minnesota, founded in 1851, is one of the
largest university in the United States, and ranks amongst the most
prestigious research universities in the world. The campus is located in the
heart of the Minneapolis-St Paul (Twin Cities) area, an enjoyable,
affordable place, extremely rich in cultural events and natural attractions.

The University of Minnesota is an equal opportunity educator and employer.

To apply, please send a CV and names for at least two referees to Mikael
Elias: mhel...@umn.edu mailto:mhel...@umn.edu  

 

[ccp4bb] Postdoctoral position available: RNA-mediated gene regulation

[Yunsun Nam]

**
Postdoctoral Position in RNA-Mediated Gene Regulation
**

The research group of Yunsun Nam at UT Southwestern Medical Center is seeking a 
postdoctoral scholar. Our laboratory is housed in a newly renovated space at 
the heart of the Cecil H. and Ida Green Center of University of Texas 
Southwestern Medical Center. Dallas offers many exciting activities, with 
affordable living costs and convenient housing options near the medical center 
campus. For more information, please visit the UT Southwestern website.

The overarching goal of our group is to elucidate the mechanistic details of 
RNA-regulated gene expression, by investigating the structure-function 
relationship of various protein/nucleic acid complexes. We are particularly 
interested in the gene regulation pathways relevant to mammalian development 
and cancer. Postdoctoral fellows will have many opportunities to learn the 
newest methods in biochemistry and biophysics, in addition to working in an 
exciting, fast evolving area in the field of biological and biomedical 
sciences. We use various approaches, including X-ray crystallography, NMR 
spectroscopy, molecular biology, nucleic acid and protein biochemistry, high 
throughput sequencing, and eukaryotic cell-based studies. For more information, 
please refer to the lab website: www.ynamlab.org. 

Candidates must have a Ph.D. degree and a strong background in biochemistry 
and/or structural biology. Interested individuals should submit a CV as a 
single pdf file to: Yunsun.Nam AT UTSouthwestern.edu. 

 *UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

[ccp4bb] Postdoctoral Position available at the University of Georgia

[Scott Pegan]

Seeking Post-Doctoral candidates for a position in my laboratory located in
the University of Georgia's Department of Pharmaceutical  Biomedical
Sciences.  This individual will assist in my ongoing NIH funded infectious
disease related projects that involve the use of structural biology
(X-ray/NMR) as well as other drug discovery and biophysical techniques. My
laboratory, and UGA at large, possesses significant Structural Biology
resources including a home source, several high field magnets,
crystallization robotics, liquid handling robots and regular access to the
SER-CAT at APS. More information on my laboratory can be found at:
http://pbs.rx.uga.edu/index.php/people/faculty/scott_pegan/

Recent graduates encouraged. X-ray, or NMR, experience a plus. Ideal start
date would be July 1, 2014. Interested parties please send a single PDF
file with your CV, with publication list included, and a minimum of
information for two references.  Please submit to spe...@uga.edu.

Scott

[ccp4bb] Postdoctoral Position Available at Rutgers University

[Matthew Neiditch]

A postdoctoral position is available in the Department of Microbiology and 
Molecular Genetics at Rutgers University - New Jersey Medical School to study 
structural mechanisms regulating bacterial signaling and perform SAR studies of 
antimicrobial compounds.  In addition to a recent Ph.D., the ideal candidate 
will have a strong background in macromolecular X-ray crystallography, 
biochemistry, protein purification, and molecular biology. A working knowledge 
of bacterial genetics and computational modeling of protein-ligand interactions 
is a plus. Candidates with demonstrated success in another field and a strong 
commitment to learning the crystallographic process will also be considered. 

Please submit: CV and at least 2 letters of reference by email to 
matthew.neidi...@rutgers.edu with the subject line “Postdoctoral Position 
Applicant”


Matthew B. Neiditch, Ph.D.
Associate Professor
Dept. of Microbiology and Molecular Genetics
New Jersey Medical School
Rutgers, The State University of New Jersey
225 Warren St., Room E450U
Newark, NJ 07103

[ccp4bb] POSTDOCTORAL POSITION AVAILABLE IN STRUCTURAL BIOLOGY

[Carine VAN HEIJENOORT]

A postdoctoral position is available at the Laboratory of Structural Biology 
and Chemistry (www.icsn.cnrs-gif.fr/guittet) of the Institute of Chemistry of 
Natural Compounds (ICSN) in Gif-sur-Yvette, France, 20km southwest of Paris.
The project aims at understanding the mechanisms of action of the 275aa, 
intrinsically disordered, C-terminal cytosolic tail of the tyrosine kinase 
receptor ErbB2, whose implication in signaling pathways is established but 
still poorly understood. Over expression of ErbB2 in breast cancer cells 
results in constitutive ligand-independent activation of tyrosine kinase 
signaling which contributes to uncontrolled proliferation, resistance to 
apoptosis and increased motility. Liquid-state NMR is our main research tool, 
complemented with various biophysical techniques available either in-house or 
in the direct vicinity of the laboratory (especially SAXS and X-Ray diffraction 
at the nearby synchrotron SOLEIL). Cellular biologists are also involved in 
this project, who will perform cellular analyses including cell proliferation 
and cell migration, thus allowing integrating the structural data in a cellular 
context.
The candidate should have a strong interest in structural biology, with good 
skills in protein biochemistry and molecular biology.  A background in 
liquid-state NMR spectroscopy is not necessary but the candidate should have a 
strong motivation to use NMR. Interested candidates should have a PhD in 
biochemistry, biophysics, chemistry or structural biology. The successful 
applicant will be exposed to a wide variety of techniques in the area of 
structural biology and possibly cellular biology. Good communication skills in 
English are required.

Our group is located at the Institute of Chemistry of Natural Compounds (ICSN) 
in Gif-sur-Yvette (45mn by train from the center of Paris) in a research campus 
mainly devoted to chemistry and biology 
(http://www.dr4.cnrs.fr/delegation/laboratoires/liste_gif.htm). The campus is 
part of the “Campus Paris Saclay” 
(http://www.campus-paris-saclay.fr/en/The-FCS), that gathers more than 1 
researchers from all research area, among which a strong research community in 
Structural Biology centered in the CNRS (french National Scientific Research 
Center) campus in Gif-sur-Yvette, Paris 11 university in Orsay, the CEA centre 
of Saclay in Gif and the French national synchrotron facility SOLEIL in Gif.  
Our laboratory is particularly well equipped with 4 NMR high field 
spectrometers ranging from 600 to 950MHz equipped with state-of-the-art 
cryoprobes for solution state protein NMR, all the equipment for protein 
production, purification and characterization and complementary biophysical 
techniques. 
Gif-sur-Yvette is an agreeable town, easily accessible from Paris, at the 
border of the «vallée de Chevreuse» regional nature reserve. 

The project is funded by the French National Research Agency, the position is 
offered for a duration of 2 years, possibly with extension, based on additional 
funding.

Motivated candidates should send their application by e-mail to 
carine.van-heijeno...@cnrs.fr. 

Applications must include a CV, a covering letter, and the names and contact 
details of at least two references.

Carine van Heijenoort, phD
ICSN-CNRS
Laboratoire de Chimie et Biologie Structurale
1 avenue de la terrasse
91190 Gif-sur-Yvette

[ccp4bb] postdoctoral position available

[Qiang Ning]

 
A postdoctoral position
in structural biology is available at Dr. Hong Ling's Laboratory in the
Department of Biochemistry, University of Western Ontario, Canada. The research
is focused on translesion DNA replication and regulation of DNA damage response.
The current projects are built on our success in cloning, expression and
purification of the key proteins in the biological systems. Combined approaches
in molecular biology, biophysics and X-ray crystallography are employed in the 
structure-function
studies of the key proteins. The laboratory is fully equipped for molecular
biology, biochemistry, biophysics and X-ray crystallography analyses. 
 



The position
requires a Ph.D. degree with experience in molecular cloning, protein 
purification,
crystallization and structure determination with prior publications. 
 
The University of Western Ontario is located in London, Ontario. London is a
comfortable city (population: 350,000) with a reasonable cost of living. It is 
close to major North American cities,
such as Toronto and Detroit.
 



Please send CV and the names of three references to Dr. Hong Ling by email
at hli...@uwo.ca. 
 
For more information, please visit 
http://www.biochem.uwo.ca/fac/ling/ling.html(http://www.biochem.uwo.ca/fac/ling/ling.html;
 target=_blankwww.biochem.uwo.ca/fac/ling/ling.html 





Hong Ling, PhD
M334 Medical Sciences Bldg.
Department of Biochemistry  
University of Western Ontario

London, Ontario
Canada N6A 5C1
Tel: 519 661-3557
Fax: 519 661-3175
Email: hli...@uwo.ca

a href=)

[ccp4bb] postdoctoral position available

[Federico Forneris]

Dear all,

We seek to appoint a Post-doctoral Training Fellow to join the newly
established Armenise-Harvard Laboratory of structural biology at the
University of Pavia. The group will focus on the molecular characterization
of extracellular ligand and receptors involved in synapse formation using a
combination of techniques including structural biology, biochemistry and
biophysics. 

More information on http://www.unipv.it/biocry/fornerislab/ 

The position will be initially available for one year and may be extended
upon positive evaluation. The application should include curriculum vitae,
publications, a cover letter explaining research interests and fit for the
position. Please also include a minimum of two personal references (name,
email and phone number).  The application should be sent via e-mail to Dr.
Federico Forneris (f.forne...@uu.nl).

Review of applications will begin immediately and the position will remain
open until filled.

Best,
F.

Federico Forneris, PhD
---
Crystal and Structural Chemistry
Bijvoet Center for Biomolecular Research - Utrecht University
Padualaan 8
3584 CH UTRECHT - The Netherlands
Tel. +31 (0) 30 253 4179 - Fax +31 (0) 30 253 3940 
http://www.crystal.chem.uu.nl/~forneris/ 
http://www.unipv.it/biocry/fornerislab/ 

[ccp4bb] Postdoctoral position available @ EMBL-Hamburg, SAXS

[margret]

Dear All,

I would like to inform you that a postdoctoral position is available at 
the EMBL Hamburg Unit in the research group of Dmitri Svergun.
I attach a brief description of the Vacancy Notice below. Deadline for 
application is 15th December 2013.
Further Detailed Information can be found under : 
http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668 
http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668


*Postdoctoral Positon, Reference HH_00053

* Applications are invited for a postdoctoral position in computational 
methods development for Biological SAXS in the BioSAXS group 
http://www.embl-hamburg.de/research/unit/svergun/index.html. The 
position is within BioStruct-X, an integrated project funded by Seventh 
Framework Programme (FP7) of the European Commission (www.biostruct-x.eu 
http://www.biostruct-x.eu). The successful candidate will participate 
in the design of an automated data analysis system to construct and 
validate 3D structural models from solution scattering data. The 
developments envisage hybrid applications of SAXS with other structural, 
biophysical and computational methods, including MX, NMR, electron 
microscopy and bioinformatic approaches..


The successful candidate will work on computational methods development 
for automated data analysis, storage and tracking, and on the 
cross-validation of SAXS models using the information from experimental 
techniques and also bioinformatic approaches. These developments are to 
be implemented at the high brilliance BioSAXS beamline of the EMBL at 
the Petra-III storage ring and also at the beamlines of the BioStruct-X 
partners.



Regards
Margret Fischer

[ccp4bb] Postdoctoral Position Available - ISMB, London

[Cara Vaughan]

A postdoctoral position is available in the Institute of Structural and 
Molecular Biology to undertake structural analysis of complexes of the 
molecular chaperone Hsp90. The position is funded by the BBSRC for two years 
and 5 months within the group of Cara Vaughan.

The researcher will be involved in all aspects of the project, from assembling 
complexes to determination of structure using both protein crystallography and 
single particle electron microscopy. The project would suit a highly motivated 
scientist interested in the molecular mechanisms of protein folding, cancer 
biology and structural biology.

Applicants must have at least a PhD in structural molecular biology with 
experience in protein crystallography or single particle electron microscopy, 
and a track record of peer-reviewed publications. Experience of eukaryotic 
multi-protein complex expression and purification will be an advantage.

The post is available from January 2014.  Informal enquires may be made to Cara 
Vaughan (c.vaug...@mail.cryst.bbk.ac.uk). Formal applications must be made via 
the website www.bbk.ac.uk/jobs, (search using reference number 11148) must be 
submitted before 10 November 2013. 

[ccp4bb] Postdoctoral Position Available

[Emmanuel Skordalakes]

A post-doctoral position is immediately available in the Skordalakes laboratory 
at The Wistar Institute  UPENN to study protein Nucleic acid assemblies that 
participate in the replication and maintenance of telomeres. We are looking for 
highly motivated candidates that have recently acquired a Ph.D. in biochemistry 
or a related field and have a record of peer reviewed publications. Preference 
will be given to candidates with prior training in RNA work and structural 
biology. Additional information regarding our research program can be found at 
the laboratory's web sites

 http://webdev.chem.upenn.edu/chem/research/faculty.php?id=52

http://www.wistar.org/lab/emmanuel-skordalakes-phd

Interested applicants should submit their CV along with three letters of 
recommendation to:

Emmanuel Skordalakes, Ph.D., Associate Professor Gene Expression and Regulation 
Program, The Wistar Institute  UPENN, 3601 Spruce St Philadelphia, PA 19104, 
sko...@wistar.org

 

 

[ccp4bb] Postdoctoral position available at The Institute of Cancer Research, London, UK.

[Rob Van Montfort]

The Institute of Cancer Research (ICR) is one of the world’s most influential 
cancer research institutes. Our mission is to make the discoveries that defeat 
cancer. We have a long and distinguished history of research with a major 
impact on the outcome for cancer patients. Our unique partnership with The 
Royal Marsden NHS Foundation Trust (RMH) makes us the largest comprehensive 
cancer centre in Europe, performing high quality original basic research and 
translational studies. The ICR was ranked as the UK’s top academic research 
centre in the 2008 Higher Education Funding Council Research Assessment 
Exercise. Based on our publication record, citations and impact we rank among 
the world’s leading cancer research centres.
The Cancer Research UK Cancer Therapeutics Unit (CTU), embedded within the 
Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' 
centre, comprising around 160 staff dedicated to the discovery and development 
of novel therapeutics for the treatment of cancer. The Cancer Therapeutics 
Unit’s exciting goal is to discover high quality drug candidates for validated 
biological targets and to progress these candidates to clinical trial. All the 
scientific disciplines are in place to make this possible, including medicinal 
chemistry, biology, drug metabolism and clinical specialists.

A postdoctoral position for a protein crystallographer is available in Dr Rob 
van Montfort’s Hit Discovery and Structural Design Team within the CTU 
(Ref:1362263). The Post-doc will be involved in high-throughput X-ray 
crystallography, fragment-based screening and structure-based drug design and 
will be responsible for crystallisation and structural analysis of 
protein-ligand complexes from one of the CTU’s drug discovery programmes. The 
successful candidate will interact closely with the biology, computational 
chemistry and medicinal chemistry teams at the CTU as well as with the protein 
crystallographers in the Division of Structural Biology in which the 
crystallography efforts of Dr van Montfort’s team are embedded. Therefore the 
successful candidate will be expected to work across the two sites in Chelsea, 
London and Sutton, Surrey.

Applicants must have a PhD in a biological or physical science, and experience 
in macromolecular crystallography (to include protein biochemistry, protein 
crystallisation,  protein crystallography). Experience in molecular biology 
and/or structure-based drug design will be an advantage.
The starting salary for the position will be in the range £28,425 to £40,628 
p.a. inclusive (based on previous post-doctoral experience) and the post is 
offered initially on a fixed term contract of 1 year in the first instance. 
Informal enquiries to 
rob.vanmontf...@icr.ac.ukmailto:rob.vanmontf...@icr.ac.uk or 
isaac.westw...@icr.ac.ukmailto:isaac.westw...@icr.ac.uk. Please DO NOT send 
your application to Dr van Montfort or Dr Westwood; applications must be 
submitted in line with the instructions on our website: 
http://www.icr.ac.ukhttp://www.icr.ac.uk/. Closing date: 30 September 2013.
Dr. Rob van Montfort
Team Leader Hit Discovery and Structural Design
Sections of Cancer Therapeutics and Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG
UK

Tel:
+44-(0)20-8722-4364 (Sutton)
+44-(0)20-7153-5142 (Chelsea)
Email: rob.vanmontf...@icr.ac.ukmailto:rob.vanmontf...@icr.ac.uk


The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company 
Limited by Guarantee, Registered in England under Company No. 534147 with its 
Registered Office at 123 Old Brompton Road, London SW7 3RP.

This e-mail message is confidential and for use by the addressee only.  If the 
message is received by anyone other than the addressee, please return the 
message to the sender by replying to it and then delete the message from your 
computer and network.

[ccp4bb] Postdoctoral position available: Structural biology of integral membrane proteins

[S Yuan]

Postdoctoral Position Available
Laboratory of Robert Stroud
Department of Biochemistry and Biophysics
University of California San Francisco, USA

SUMMARY DESCRIPTION:
Structural Biology
The Stroud Laboratory seeks a postdoctoral fellow to pursue the
structural characterization of integral membrane proteins critical to
metabolism in cancer. The successful candidate will work with
top-tier biological collaborators and forefront technologies.
Experience with expression in eukaryotic cells.

The successful candidate will have the opportunity to:
1. Express biologically relevant integral membrane proteins in a
variety of systems (mammalian, insect, yeast, bacterial)
2. Purify target membrane proteins to homogeneity
3. Crystallize and determine the macromolecular structure of these
proteins, both alone and, where applicable, in complex with their
ligand(s)

START DATE: Immediately

REQUIREMENTS:
1. Experience in the expression of eukaryotic proteins using
eukaryotic systems
2. Some experience in protein purification and biochemical characterization
3. A desire to learn about membrane protein biochemistry and
macromolecular protein crystallography.

APPLICATION:
Please send (1) your CV, (2) your resume, describing your relevant
skills, and (3) a list of three references to: stroud...@gmail.com

[ccp4bb] PostDoctoral position available at Sanofi RD in Paris area

[Alexey Rak]

Dear All,
I would like to bring to the ccp4b attention that a PostDoc position in 
bio-physics is available in structural biology labs at Sanofi RD in Paris area.
Please see the announcement below.
Best regards,
Alexey

Alexey RAK, PhD
Structure-Design-Informatics / LGCR / Sanofi RD
13, Quai Jules Guesde - BP 14Phone: +33 (0) 1 58 93 86 93
94403 Vitry sur Seine Cedex   Fax: +33 (0) 1 58 93 80 63
FRANCE 
alexey@sanofi.commailto:alexey@sanofi.com
[cid:image002.jpg@01CE6D97.C9B4ED50]
Please consider the environment before printing this email!


_


A post-doctoral fellowship is available for a period of 18 months in the 
department Structure, Design  Informatics at SANOFI RD, Vitry-sur-Seine, 
France, in the field of BioPhysics.

The post doc project is aiming at developing novel biophysical applications to 
characterize biomolecular interaction for a wide range of affinities, molecules 
size and experimental conditions, to be routinely applied in current small 
molecule and biologics projects. The methods will focus on protein interaction 
characterization as well as on kinetic and thermodynamic parameters evaluation.
Candidates must hold a PhD degree in Biophysics or Biochemistry or related 
fields. They must have experience documented by peer-refereed publications in 
the biomolecular interaction characterization. They must have experience with 
NMR, SPR, ITC and DSF methods, structural biology or recombinant protein 
biochemistry experience is an advantage.
Outstanding commitment to successfully perform research and meet the project 
objectives is required as well as capacities in team work and interdisciplinary 
communication.  Mastering scientific English, both written and spoken, is 
essential; knowledge of French is beneficial although not required.
If you meet the requirements and wish to contribute to this project, please 
send before July 15, 2013 a complete resume with a cover letter to Marie Pouyet 
at Sanofi marie.pou...@sanofi.commailto:marie.pou...@sanofi.com. In the 
application, please, include name and contact details of three scientific 
referees.

The starting date is September - December 2013.
Location : Vitry-sur-Seine - Paris areas
Sanofi, an integrated global healthcare leader, discovers, develops and 
distributes therapeutic solutions focused on patients' needs. Sanofi has core 
strengths in the field of healthcare with seven growth platforms: diabetes 
solutions, human vaccines, innovative drugs, consumer healthcare, emerging 
markets, animal health and the new Genzyme.

inline: image001.jpg

[ccp4bb] postdoctoral position available in the Pyle lab at Yale

[Marco Marcia]

Dear all
on behalf of Prof. Pyle, I would like to inform you that a postdoctoral 
position is available in our lab at Yale. Please, see announcement below.

Kind regards
Marco Marcia


The Pyle laboratory at Yale (www.pylelab.org) is looking for an 
exceptional and highly motivated postdoctoral candidate to work on 
structural and functional analysis of proteins involved in RNA 
recognition and remodeling, or with an interest in RNA tertiary 
structure. An interest in the development of small molecules for 
targeting RNAs and RNA-protein complexes is also welcome. See recent 
examples of our work in Luo D., et al. (2011) Cell 147, 409, Luo D., et 
al. (2012) Structure 20, 1983, Marcia and Pyle (2012) Cell 151, 497. 
Candidates must have experience in protein or nucleic acid structure 
determination by X-ray crystallography and solid and demonstrated 
success in molecular biology, protein expression, purification, and 
crystallization. Excellent communication skills are essential. At Yale, 
our lab is part of an interactive group of structural biologists sharing 
common home source X-ray facilities and dedicated access to beamlines at 
APS.
Applicants must have a PhD and less than one year of postdoctoral 
experience. Please send CV, including the names and addresses of three 
references, to


Anna Marie Pyle, Ph.D., Professor
Yale University, KBT, Room 826
PO Box 208103, 219 Prospect Street
New Haven, CT 06520-8103
Tel: +1-203-809-5585
E-mail: anna.p...@yale.edu



--
_

Dr. Marco MARCIA
Yale University, KBT 834
266, Whitney Avenue
New Haven, CT - 06511
USA

phone (lab): +1-203-432-6370
phone (office): +1-203-432-5546
fax: +1-203-432-5316
email: marco.mar...@yale.edu
web: http://www.pylelab.org

[ccp4bb] postdoctoral position available in the Pyle lab at Yale

[Marco Marcia]

Dear all
on behalf of Prof. Pyle, I would like to inform you that a postdoctoral
position is available in our lab at Yale. Please, see the announcement below.
Kind regards
Marco Marcia


The Pyle laboratory at Yale (www.pylelab.org) is looking for an
exceptional and highly motivated postdoctoral candidate to work on
structural and functional analysis of proteins involved in RNA
recognition and remodeling, or with an interest in RNA tertiary
structure. An interest in the development of small molecules for
targeting RNAs and RNA-protein complexes is also welcome. See recent
examples of our work in Luo D., et al. (2011) Cell 147, 409, Luo D., et
al. (2012) Structure 20, 1983, Marcia and Pyle (2012) Cell 151, 497.
Candidates must have experience in protein or nucleic acid structure
determination by X-ray crystallography and solid and demonstrated
success in molecular biology, protein expression, purification, and
crystallization. Excellent communication skills are essential. At Yale,
our lab is part of an interactive group of structural biologists sharing
common home source X-ray facilities and dedicated access to beamlines at
APS.
Applicants must have a PhD and less than one year of postdoctoral
experience. Please send CV, including the names and addresses of three
references, to

Anna Marie Pyle, Ph.D., Professor
Yale University, KBT, Room 826
PO Box 208103, 219 Prospect Street
New Haven, CT 06520-8103
Tel: +1-203-809-5585
E-mail: anna.p...@yale.edu




--
_

Dr. Marco MARCIA
Yale University, KBT 834
266, Whitney Avenue
New Haven, CT - 06511
USA

phone (lab): +1-203-432-6370
phone (office): +1-203-432-5546
fax: +1-203-432-5316
email: marco.mar...@yale.edu
web: http://www.pylelab.org

[ccp4bb] Postdoctoral position available @ EMBL-Hamburg, SAXS

[margret]

Dear All,

I would like to inform you that a postdoctoral position is available at 
the EMBL Hamburg Unit in the research group of Dmitri Svergun.
I attach a brief description of the Vacancy Notice below. Deadline for 
application is 31st August 2013.
Detailed information can be found under : 
http://ig14.i-grasp.com//fe/tpl_embl01.asp?newms=jjid=51531aid=15470 
http://ig14.i-grasp.com/fe/tpl_embl01.asp?newms=jjid=51531aid=15470


*Postdoctoral Positon, Reference HH_00046*

Applications are invited for a postdoctoral position in computational 
methods development for biological SAXS in the BioSAXS group 
http://www.embl-hamburg.de/research/unit/svergun/index.html.The 
position is funded by *BioStruct-X*, an integrated project within the 
Seventh Framework Programme (FP7) of the European Commission 
(www.biostruct-x.eu http://www.biostruct-x.eu).


The fellow will participate in the design of an automated data analysis 
system to construct and validate structural models from solution 
scattering data. The developments envisage hybrid applications of SAXS 
with other structural, biophysical and computational methods, including 
MX, NMR, electron microscopy and bioinformatic approaches.


The candidate should have a PhD in physics, mathematics or biology and 
knowledge in computational and numerical methods. Experience in the use 
of programming languages (Fortran, C/C++ and/or Python) is essential. We 
specifically welcome applicants with background in computational 
crystallography, NMR, electron microscopy and/or bioinformatics. Good 
communication skills and the ability to collaborate with international 
teams are required.


on behalf of Dmitri Svergun

Margret Fischer

[ccp4bb] Postdoctoral position available at University of Texas Southwestern Medical Center

[Diana Tomchick]

This message is posted for Eric Olson, Ph.D. (Chair of Molecular Biology), who 
is looking for a postdoctoral fellow to join his lab to work on a novel 
membrane protein (first described in Nature, in press). See project description 
below and if interested please contact him at:

Email: eric.ol...@utsouthwestern.edumailto:eric.ol...@utsouthwestern.edu

Eric N. Olson, Ph.D.
Chair and Professor
Department of Molecular Biology
UT Southwestern Medical Center at Dallas
5323 Harry Hines Blvd.
Dallas, TX 75390-9148
214-648-1187 phone
214-648-1196 fax
http://www4.utsouthwestern.edu/olsonlab/index.html

Project Description:
We have discovered a novel muscle-specific membrane protein that is necessary 
and sufficient to induce the fusion of muscle cells to form multinucleated 
muscle fibers.  The process of myoblast fusion has been the focus of intense 
interest for decades but, until now, no muscle-specific fusigen has been 
discovered.  This fusigenic protein is highly hydrophobic and localized to the 
plasma membrane.  One of our major goals is to understand at the structural 
level how such a protein can promote the merger of membranes between cells.  We 
hope to recruit a structural biologist to determine the crystal structure of 
this fusigenic protein and then to introduce mutations to perturb its structure 
to further understand the mechanistic basis of its actions.  This project has 
the potential to yield important new insights into general properties of 
membrane fusion.  This project will offer a unique opportunity for a young 
scientist to establish a reputation in an important area of cell biology and to 
independently extend this work in the future.

Facilities Description:
State-of-the-art equipment is shared between the members in the Structural 
Biology community at UT Southwestern and consists of one Rigaku FR-E 
SuperBright high brilliancy X-ray generator equipped with one set of 
high-resolution and one set of high-intensity X-ray optics, two imaging-plate 
X-ray detectors (one R-Axis IV++ and one R-Axis IV), two X-Stream crystal 
cooling devices, and one automated sample-mounting device (ACTOR) for the 
unattended screening of crystals; a Phoenix crystallization robot, plus two 
Desktop Minstrel imaging systems and a Gallery-160 Plate Hotel; 30 days per 
year of beamtime at beamlines 19ID at the Advanced Photon Source (APS), 
Argonne, IL; several NMR spectrometers (one 800 MHz, three 600 MHz, two 500 
MHz), cryo-probes and robotic sample changer.  These facilities are 
supplemented by a variety of biophysical instruments supporting the study of 
macromolecules using CD, dynamic light scattering, analytical 
ultracentrifugation, stopped-flow kinetics, isothermal titration calorimetry, 
microscale thermophoresis and mass spectrometry. Several investigators in the 
UT Southwestern Structural Biology community are expert membrane protein 
crystallographers, and have access to specific equipment and expertise related 
to construct optimization, crystallization and structure solution of membrane 
proteins.

Diana

* * * * * * * * * * * * * * * * * * * * * * * * * * * *
Diana R. Tomchick
Professor
University of Texas Southwestern Medical Center
Department of Biophysics
5323 Harry Hines Blvd.
Rm. ND10.136EB (until the end of July)
Dallas, TX 75390-8816, U.S.A.
Email: 
diana.tomch...@utsouthwestern.edumailto:diana.tomch...@utsouthwestern.edu
214-645-6383 (phone)
214-645-6353 (fax)









UT Southwestern Medical Center
The future of medicine, today.

[ccp4bb] Postdoctoral position available at University of Wisconsin at Madison

[Yongna Xing]

 
You are invited to apply for a postdoctoral position in the structural biology 
lab of McArdle Cancer Institute of University of Wisconsin at Madison. We are 
interested in understanding the structural basis of protein phosphatase 2A 
(PP2A) regulation and its cross-talk to cellular and viral kinases in 
controlling signaling proteins involved in cell cycle, DNA damage response, and 
cell metabolism. One important aspect of the study is to elucidate mechanisms 
of protein chaperones in modulating the function of diverse PP2A complexes, 
kinases and nuclear receptors in response to cellular and environmental signals 
using structural biology techniques in combination of biochemical and 
biophysical methods and cell biology approaches. Initial results of this 
specific aspect of study can be found in our recent publications (Nat. Commun., 
4:1699, 2013; Molecular Cell 41, 1–12, 2011).
 
 
 
The lab is equipped with a state-of-the-art setup for x-ray crystallographic 
studies, including crystallography robot, and have convenient monthly access to 
powerful x-ray beamlines at APS. The researcher will work in a 
multidisciplinary setup, including cell biology, biophysics, proteomics, and 
protein biochemistry, in addition to protein crystallography. 
 
 
 
Candidates should hold a PhD in protein biochemistry and crystallography and 
have a good working knowledge of molecular biology techniques. The candidates 
should be highly motivated, goal-driven, and dedicated individuals who can 
think critically and work both independently and collaboratively with good 
verbal and written communication skills. It is also important that the 
candidates are creative in problem solving and have a strong desire to seek 
answers to questions related to the molecular basis of cellular processes. 
Experience in cell culture techniques and writing scientific research papers 
would be advantageous. Eligibility to training grant is appealing, but not 
essential.
 
 
 
This is a full-time position with a starting salary of $39,264 – 44,340 per 
year depending on skills and experience.
 
 
 
Review of applications will begin immediately and continue until the positions 
are filled.
 
 
 
To apply: Please send a cover letter, CV and the names and contact information 
for three references to Dr. Yongna Xing, 1400 University Avenue, McArdle 
Laboratory for Cancer Research, University of Wisconsin-Madison-Madison, WI 
53706. Email: yx...@oncology.wisc.edu.

[ccp4bb] Postdoctoral Position available at Brown University, Providence, RI

[Page, Rebecca]

The Page Laboratory at Brown University has an opening for a highly
motivated postdoctoral research scientist to undertake structural analysis
of signaling complexes, with a focus on the interactions between
phosphatases, kinases and their regulatory proteins. Most studies typically
employ a combination of x-ray crystallography, NMR spectroscopy and SAXS.
Applicants with a strong background in biochemical techniques and structure
determination are encouraged to apply.

The Page laboratory is housed in a 105,000 sq. ft. research laboratory in
Providence, RI. The laboratories are open-lab-space facilities and allow
for close interactions with the adjunct structural biology and molecular
biology groups at Brown University. Recent upgrades to the Brown University
structural biology infrastructure include new X-ray crystallography
instrumentation (Rigaku FR-E+ SuperBright with VariMax-HF ArcSec optics, a
Saturn 944 CCD detector and ACTOR robotic crystal mounting system), a
BIOSAXS-1000 small angle X-ray scattering instrument, and the addition of
an 850 MHz NMR spectrometer.

Providence, RI, is located on the coast between Boston (45 min.) and New
York City (3 hours). Starting date, salary and project details are
negotiable.

Please e-mail a Cover Letter and CV to Rebecca Page (rebecca_p...@brown.edu),
Brown University, Box G-E4, Providence, RI 02912.

[ccp4bb] Postdoctoral Position Available at AstraZeneca in Waltham, MA

[Prince, D Bryan]

At AstraZeneca, we're constantly striving to make new discoveries.
Discoveries that will make a meaningful difference to health globally.
We already have an exceptional product pipeline, and everyone here has a
part to play in making sure that pipeline fulfills its potential.  This
is your opportunity to join them - and to fulfill your own.



We have an exciting opportunity for a biochemist / biophysicist /
crystallographer to join the Structure  Biophysics group at AstraZeneca
in Waltham, MA.  This is a collaborative effort with the laboratory of
Professor Jamie Cate at the University of California Berkeley to
understand the structural basis of mechanism-based toxicity to
antibiotic treatment.  Success in generating chimeric ribosomes will
result in novel means to assess antibacterial sensitivity using a suite
of genetic, biochemical and biophysical approaches.



This position provides an opportunity to explore the gene-to-structure
process in an industrial setting.  You'll be exposed to a variety of
aspects within the drug discovery cascade, and will interact with
scientists in a cross-disciplinary environment.  You'll also be expected
to deliver your novel research results within AstraZeneca, and
externally via scientific conferences and peer-reviewed publications.



* Build an understanding of antibiotic selectivity for the bacterial
ribosome through the design and analysis of the functional activity of
chimeric ribosomes
* Assess the antibacterial sensitivity of recombinant bacterial strains
containing chimeric ribosomes against a panel of known ribosomal
inhibitors

* Understand the structural basis of ribosomal inhibitor selectivity by
performing crystallography on chimeric ribosomes in complex with
antibiotics

* Work collaboratively with scientists across various disciplines to
achieve project objectives

* Externally present results at scientific conferences, and publish
scientific papers in high quality peer-reviewed journals

A PhD in one or more of the following areas:
* Protein/RNA biochemistry

* Biophysics, crystallography, ribosome biology, molecular microbiology


* Molecular biology, expression and purification skills to independently
produce high-quality RNA-protein complexes
* Experience with multiple biochemical and biophysical techniques to
assess the quality, stability and function of RNA-protein complexes
* Experience in performing antibacterial sensitivity assays
* Experience in designing complex reagents for biophysical and
crystallographic studies
* Crystallographic experience is highly desirable
* Strong written and oral communication skills


As one of the world's leading pharmaceutical companies, our business is
focused on providing innovative, effective medicines that make a real
difference in important areas of healthcare. What's more, we support and
encourage our people in discovering their own potential. Excellent
learning and development opportunities will be available to you
throughout your career here.



Please follow this link to view the full advertisement and online
application:



http://jobs.astrazeneca.com/jobs/23176-postdoctoral-position-synthetic-b
iology-to-probe-ribosomal-inhibitor-selectivity




--
Confidentiality Notice: This message is private and may contain confidential 
and proprietary information. If you have received this message in error, please 
notify us and remove it from your system and note that you must not copy, 
distribute or take any action in reliance on it. Any unauthorized use or 
disclosure of the contents of this message is not permitted and may be unlawful.
 

[ccp4bb] Postdoctoral position available @ EMBL-Hamburg, SAXS

[margret]

Dear All,

I would like to inform you that a postdoctoral position is available at 
the EMBL Hamburg Unit in the research group of Dmitri Svergun.
I attach a brief description of the Vacancy Notice below. Deadline for 
application is 14th April 2013.
Further Detailed Information can be found under : 
http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668


*Postdoctoral Positon, Reference HH_00042

*Applications are invited for a postdoctoral position in the BioSAXS 
group http://www.embl-hamburg.de/research/unit/svergun/index.html. The 
position is within BioStruct-X, an integrated project funded by Seventh 
Framework Programme (FP7) of the European Commission (www.biostruct-x.eu 
http://www.biostruct-x.eu). In the framework of this project BioSAXS 
group develops novel hardware and software components for the high 
brilliance SAXS beamlines and for the interdisciplinary use of SAXS with 
other structural, biophysical and bioinformatic methods.


The successful candidate will work on computational methods development 
for automated data analysis, storage and tracking, and on the 
cross-validation of SAXS models using the information from experimental 
techniques and also bioinformatic approaches. These developments are to 
be implemented at the high brilliance BioSAXS beamline of the EMBL at 
the Petra-III storage ring and also at the beamlines of the BioStruct-X 
partners.



Regards
Margret Fischer

[ccp4bb] Postdoctoral position available : Crystallization of CFTR

[Cedric Govaerts]

Nanobody-aided crystallization and structure determination of CFTR

Start date : march  1st 2013

The project: 
Cystic Fibrosis (CF or mucoviscidosis), is a fatal genetic disorder affecting 
one in 2500 newborn. It is caused by mutation in the CFTR, a chloride channel, 
leading to destabilization, degradation and malfunctioning of the protein. 
Obtaining the molecular structure of CFTR will represent a major breakthrough 
both for our understanding of the protein function /dysfunction but also to 
provide new avenues for therapeutic strategies.  The project aims at obtaining 
the crystal structure of CFTR by combining cutting edge methodologies  such as 
Lipidic Cubic Phase-based crystallography and nanobody stabilization of CFTR. 

Host  laboratories: 
As a joint effort between 3 laboratories, the project is coordinated by Dr C. 
Govaerts at the Structure and Function of Membrane Biology Laboratory (SFMB,) 
affiliated with the Université Libre de Bruxelles and is located in Brussels, 
Belgium, the capital of Europe.  A large part of the training and of the 
crystallization work will take place in the laboratory of Prof Martin Caffrey, 
Trinity College Dublin, Ireland, a pioneer in the LCP methodology. Finally, 
part of the work will be performed in the laboratory of Prof John Riordan, a 
discoverer of CFTR, located at University of North Carolina in Chappell Hill, 
USA. 

Profile: 
Candidates should have a PhD and have a background in biochemistry, protein 
expression and purification, preferably with membrane proteins.  Experience 
with structural biology, specifically protein crystallization is a plus. The 
successful candidate must be creative, self-motivated,  persistent, resourceful 
and be willing to travel between the different labs and enjoy working both 
independently and in a collaborative setting. 

Applications: 
Send a CV, a list of publications, a short overview of research activities and 
the name of two or more references to cedric.govae...@ulb.ac.be. Preselected 
applicants will be requested to travel to Brussels for a lecture and an 
interview.

[ccp4bb] Postdoctoral position available@SAXS, EMBL Hamburg

[margret]

Dear All,

I would like to inform you that a postdoctoral position is available at 
the EMBL Hamburg Unit in Small Angle Scattering in the research group of 
Dmitri Svergun.
I attach a brief description of the Vacancy Notice below. Deadline for 
application is 15th July 2012.
Further Detailed Information can be found under : 
http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668


Regards
Margret Fischer
---


*Postdoctoral Positon, Reference HH_00028*
Applications are invited for a postdoctoral position in the BioSAXS 
group (www.embl-hamburg.de/research/unit/svergun), which develops new 
approaches
to analyze the structure of biological macromolecules in solution using 
synchrotron radiation. The successful candidate will work on the 
interdisciplinary project
to understand the physical principles in the self-assembly of immature 
human immunodeficiency virus type 1 particles. The approach, supported 
by a grant
from the Human Frontiers Science Program, brings together teams from the 
USA, Germany and the Netherlands involving experts in retroviral 
molecular biology,
theoretical physics, materials chemistry and structural biology. The 
fellow is expected to design and perform time-resolved and anomalous 
synchrotron SAXS
experiments and to build structural models for the subunit assembly on 
specific templates, in close collaboration with the partners on the project.

[ccp4bb] Postdoctoral Position Available in Structural Biophysics and Protein Engineering in Rockville, Maryland, USA

[Scott Walsh]

A NIH funded postdoctoral position is available at the Institute for Bioscience 
 Biotechnology Research (IBBR) at the University of Maryland in Rockville, 
Maryland, USA.  Several research projects are available to study the 
interleukin-7 signaling 
pathway at the structural, biochemical, and biophysical levels.  Candidates 
must have a Ph.D. degree in biochemistry or a related field, with experience in 
molecular biology, bacterial/insect cell protein expression and purification.  
Prior experience in structural (X-ray crystallography or NMR spectroscopy) and 
biophysical techniques is preferred.  Salary will be commensurate upon 
experience.  For further information 
(http://www.ibbr.umd.edu/profiles/scott-walsh) or to apply for the position 
please send a cover letter, CV, and two references to Dr. Scott Walsh (email: 
swals...@umd.edu).

Re: [ccp4bb] Postdoctoral Position Available in Houston

[Spudich, John L]

Description:  A postdoctoral position is available immediately to study the 
structure and function of microbial sensory rhodopsins, including 
channelrhodopsins. The position requires a recent Ph.D. in one of the natural 
sciences relevant to structural biochemistry. Applicants must be highly 
motivated and have experience with protein purification and crystallization.  
Experience with membrane proteins is an advantage.  Salary will be commensurate 
with experience and will be in addition to a fringe benefit package.  Our lab 
in the Center for Membrane Biology, Department of Biochemistry  Molecular 
Biology, University of Texas Health Science Center at Houston, is well equipped 
for molecular biology, protein chemistry, and protein crystallography.  In 
addition, our University is part of the Molecular Biology Consortium that 
operates its own high flux MAD-capable x-ray beamline at ALS Berkeley, 
California. Apply to 
john.l.spud...@uth.tmc.edumailto:john.l.spud...@uth.tmc.edu including your CV 
and names of 3 references.

[ccp4bb] Postdoctoral position available in UCSF to study structural biology of HIV-host interaction

[Robert Stroud]

Postdoctoral Position Available
Laboratory of Professor Robert M. Stroud, Ph.D. (
http://www.msg.ucsf.edu/stroud/index.htm)
Department of Biochemistry and Biophysics
University of California San Francisco, USA

SUMMARY DESCRIPTION: Structural biology of HIV-host interaction

The Stroud Laboratory seeks a postdoctoral fellow to pursue the structural
characterization of protein-protein complexes between HIV-1Integrase (IN)
and Vpu and their human interacting partners. The HIV initiative in Stroud
lab is part of larger effort in UCSF to understand HIV-host interaction (
http://harc.ucsf.edu/). This position offers the opportunity to work in
highly collaborative and intellectually stimulating environment.

The successful candidate will have the opportunity to:

1. Express and purify HIV-host protein-protein complexes
3. Crystallize and determine the macromolecular structure of these proteins
and protein-protein complexes

START DATE: Preference will be given to candidates who can start immediately

REQUIREMENTS:
Ph.D. in biochemistry, biophysics and structural biology. Experience with
expression of recombinant proteins in variety of hosts (E.coli, SF9 etc.)
and purification of proteins to a high degree of homogeneity are required.
Prior experience with protein crystallization and structure determination is
strongly desirable. Experience with biochemical assays and analyzing
protein-protein interactions is also desirable.

APPLICATION:
Please send your CV/Resume describing your relevant skills and a list of
three references to:  stroud...@gmail.com

[ccp4bb] Postdoctoral position available

[Brian Mark]

POSTDOCTORAL POSITION AVAILABLE

Applications are invited for a postdoctoral position to investigate the 
structural and cellular biology of viral immune evasion tactics and assembly 
mechanisms of Bunyaviruses, the largest family of negative-strand RNA viruses.  
The family Bunyaviridae includes a number of emerging viruses of human and 
agricultural importance and much remains to be discovered about their life 
cycle and the mechanisms they use to subvert the innate immune system.  
The following is an example of our recent work in this area:  James TW, et al. 
(2011). Proc Natl Acad Sci U S A. 108(6):-7.

A number of exciting projects are underway and ready to carry forward.  More 
information about our lab can be found at: 
http://home.cc.umanitoba.ca/~bmark/Welcome.html
 
We seek enthusiastic applicants who hold a PhD in biochemistry or related 
field. Candidates must have a strong background in molecular biology and 
protein X-ray crystallography. Expertise in mammalian cell culture and 
fluorescence microscopy would be considered strong assets.
 
Our group is located in the Department of Microbiology, University of Manitoba, 
Winnipeg, Canada. The laboratory includes state-of-the-art X-ray 
instrumentation (Rigaku) and crystallization robotics (Art Robbins).  We have 
routine access to the Canadian Light Source Synchrotron via mail-in service, 
remote control of robotics, or in person (within driving distance).
 
The University of Manitoba (http://umanitoba.ca/) is the largest University in 
the province (over 30,000 students, faculty, and staff) and hosts a dynamic 
biomedical research community.  Winnipeg is a vibrant, multicultural city with 
numerous cultural events, festivals and a brand new NHL hockey team 
(http://www.destinationwinnipeg.ca/).  With over 110,000 fresh water lakes in 
our province alone, there is also much to explore for those who love the 
outdoors.
 
Salary will be in accordance with the Canadian Institutes of Health Research 
(CIHR) (http://www.cihr.ca/ ) standards.  Fellowship funding is also available 
through agencies such as the CIHR and the Manitoba Health Research Council 
(MHRC) (http://www.mhrc.mb.ca/).
 
All qualified candidates are encouraged to apply.
 
Please direct formal and informal inquiries and CV's (including names of three 
referees) to my email address:
 
brian_m...@umanitoba.ca


=
Brian Mark, MSc, PhD
Associate Professor
Manitoba Research Chair in Structural Biology
Department of Microbiology
 Department of Biochemistry and Medical Genetics

Mailing/Courier address:
Department of Microbiology
418 Buller Building
University of Manitoba
Winnipeg, Manitoba 
CANADA R3T 2N2

Phone (204) 480-1430
Fax (204) 474-7603
Web:  http://home.cc.umanitoba.ca/~bmark/Welcome.html

[ccp4bb] Postdoctoral position available at Caltech

[Andre Hoelz]

The Hoelz laboratory at the California Institute of Technology seeks to recruit 
an outstanding postdoctoral scientist in structural biology. Our laboratory 
focuses on the structure-function relationships of multi-protein macromolecular 
assemblies. Major research themes are (1) the nuclear pore complex and 
evolutionarily-related vesicle coats, and (2) histone modifying enzymes and 
their resident multi-protein complexes.

For recent publications, see, for example, Stavropoulos et al., NSMB, 2006; 
Hsia et al., CELL, 2007; Melcak et al., SCIENCE, 2007; Debler et al., MOL. 
CELL, 2008; Nagy et al., PNAS, 2009; Hsia et al., PNAS, 2010; Hoelz et el., 
Annu Rev. Biochem., 2011.

This position requires a recent Ph.D. degree in biochemistry/biophysics with a 
strong background in x-ray crystallography. The successful applicant should be 
a highly motivated individual with good organizational, communication, and 
interpersonal skills, who is able to carry out a structure determination 
project from protein expression to structure refinement.

The laboratory is newly constructed, well-funded, and well-equipped with modern 
biophysical instrumentation and current crystallization robotics. Importantly, 
Caltech has an exceptional infrastructure for macromolecular crystallography, 
including 40 % access to a high intensity, completely automated, 
state-of-the-art crystallography beamline equipped with a PILATUS detector at 
the Stanford Synchrotron Radiation Lightsource (SSRL).

The position is available immediately and funded for 2+ years. Depending on 
performance, the position can be extended for up to five years.

To apply, please send your CV, a statement of research interests, and the names 
and contact information of at least two references to André Hoelz 
(ho...@caltech.edu).

[ccp4bb] Postdoctoral position available: Structural biology of human tight junction membrane proteins

[Laboratory of Professor Robert Stroud]

Postdoctoral Position Available
Laboratory of Professor Robert M. Stroud, Ph.D.
Department of Biochemistry and Biophysics
University of California San Francisco, USA

SUMMARY DESCRIPTION: Structural biology of human tight junction membrane 
proteins

The Stroud Laboratory seeks a postdoctoral fellow to pursue the structural 
characterization of a family of integral membrane proteins critical to tight 
junction formation and function. These proteins are widely expressed and are 
implicated in the pathogenesis of many human diseases, including breast and 
ovarian cancers, inflammatory bowel disease, inherited deafness, hepatitis 
virus infection, and renal tubule electrolyte transport disorders. As this work 
is funded by a NIH PSI Biology grant, the successful candidate will work with 
top-tier biological collaborators.

The successful candidate will have the opportunity to:

1. Express biologically relevant integral membrane proteins in a variety of 
systems (mammalian, insect, yeast, bacterial)
2. Purify target membrane proteins to homogeneity
3. Crystallize and determine the macromolecular structure of these proteins, 
both alone, and, where applicable, in complex with their ligand(s)

START DATE: Immediately

REQUIREMENTS:
1.  Experience in the expression of eukaryotic proteins using eukaryotic  
systems
2.  Some experience in protein purification and biochemical characterization
3.  A desire to learn about membrane protein biochemistry and macromolecular 
protein crystallography.

APPLICATION:
Please send (1) your CV, (2) your resume, describing your relevant skills, and 
(3) a list of three references to:  stroud...@gmail.com

[ccp4bb] Postdoctoral position available

[Stewart Turley]

This notice is posted on behalf of Wim Hol.  Please send inquiries to him at 
the email address at the bottom of the page.


Postdoctoral Position Available 
Laboratory of Wim Hol
Department of Biochemistry, School of Medicine
University of Washington, Seattle, USA

Structural Biology of the type II secretion system 
from pathogenic bacteria 

The projects in Wim Hol’s protein crystallography group at the University of 
Washington are all focused on providing a basis for development of new 
therapeutics for tropical diseases. This particular postdoctoral position is 
within a collaborative project which aims to unravel the architecture, 
mechanism of action and biogenesis of the” type II secretion system” (T2SS).  
The sophisticated T2SS occurs in many pathogenic bacteria.  This machinery is 
responsible for translocating a wide variety of proteins in a folded state from 
the periplasm across the outer membrane into the extracellular milieu. One of 
these proteins is cholera toxin which has been studied intensively in the Hol 
lab. The large T2SS consists of  ~14 different proteins that span the inner and 
the outer membrane, and is associated with  a secretion ATPase in the cytoplasm 
which provides the energy for the secretion process. Another remarkable feature 
of the T2SS is a helical sub-assembly in the periplasm !
 which is likely serving as a piston pushing cholera toxin and other 
exoproteins through a pore in the outer membrane.

The successful candidate will have the opportunity to: 
(i) carry out protein expression and protein chemistry studies to obtain 
insight into protein-protein interactions involving the T2SS from pathogenic 
bacteria like Vibrio cholera, enterotoxigenic E. coli, and other bacteria;
(ii) purify and characterize multi-membrane protein complexes;
(iii) determine high resolution crystal structures of multi-protein 
sub-complexes of the machinery; 
(iv) apply electron microscopy techniques in the laboratory of Dr. Tamir Gonen 
to enhance our insight into the architecture and functioning of the T2SS;
(v) combine the results of electron microscopy and crystallography.

For more information regarding the laboratory of Wim Hol see the following 
websites:
http://www.bmsc.washington.edu/WimHol/
http://depts.washington.edu/biowww/faculty/hol.html
and regarding the laboratory of Tamir Gonen:
http://depts.washington.edu/biowww/faculty/gonen.html


START DATE: Immediately

INSTITUTION: Department of Biochemistry 
Biomolecular Structure Center
School of Medicine
Box 357742
University of Washington
Seattle, WA, 98195  USA


Requirements
Experience with membrane protein preparation, characterization and 
crystallography.

Application
If you are interested, please send your CV, including a description of your 
experience and technical know-how, a list of publications and presentations, 
and names and email addresses of three references able to assess your 
scientific experience and capabilities to: wg...@u.washington.edu

[ccp4bb] Postdoctoral Position Available in London

[Steiner, Roberto]

Dear CCP4-ers,
_
Postdoctoral position in reactive oxygen species (ROS) biology

A postdoctoral position supported by the King’s College London British Heart 
Foundation Centre of Excellence is available at King’s College London in the 
field of ROS biology. The project is a collaborative effort amongst the groups 
of Prof Ajay Shah MD (Cardiovascular Division, King’s College London), Dr Conte 
and Dr Steiner (Randall Division of Cell and Molecular Biophysics, King’s 
College London) aimed at elucidating the molecular mechanism of controlled ROS 
production in higher organisms.

The project is highly interdisciplinary and will combine structural biology 
(X-ray and NMR) with biophysical (ITC), biochemical and cell biology work. The 
post requires experience in molecular biology/protein biochemistry. Proven 
prior experience in protein expression using the baculovirus system is also 
considered very important. Additional experience with biophysical methods 
complementary to structural biology and/or oxygen biochemistry is welcomed.

The post is available immediately and funding is initially available for 18 
months. Salary will be commensurate to prior experience and qualifications. 
Interested applicants should contact Dr Roberto A Steiner 
(roberto.stei...@kcl.ac.ukmailto:roberto.stei...@kcl.ac.uk ) directly by 
submitting their CV together with the names of three referees. Informal 
inquiries are welcome.
Deadline for this application is 21st March 2011.
_

Best wishes
Roberto

[ccp4bb] Postdoctoral position available at the Noble Foundation

[Wang, Xiaoqiang]

A Postdoctoral position is available in the Structural Biology
Laboratory in the Plant Biology Division at the Samuel Roberts Noble
Foundation, Ardmore, Oklahoma, USA, to study structures of proteins
involved in natural product biosynthesis, nutrient uptake, and gene
regulation by using crystallography as the main experimental technique.
The lab is well equipped with state-of-the-art equipment for molecular
biology, protein biochemistry, and crystallography, including
AKTAPurifers, Phoenix crystallization robot and an R-AXIS IV++ detector
with a RU-H3R rotating anode generator and X-stream cryosystem.
Applicants should have a Ph.D. with experience in crystallography and
protein expression and purification. Starting salaries begin at $41,200
with excellent benefits. Informal inquiries can be made to Dr. Xiaoqiang
Wang (Email: xw...@noble.org mailto:xw...@noble.org ).



Application Instructions: Applicants are requested to apply online by
completing the application and submitting a resume, contact information
for three references, and a cover letter explaining interest in the
position and career goals.  Applications will be accepted until a
candidate is hired.  Interested applicants should apply at 

http://www.noble.org/Jobs/WebsiteEmployment/WebsiteEmployment.aspx
(Position ID PB-S095-52). 

 
Xiaoqiang Wang, Ph.D

Associate Professor

Plant Biology Division

Samuel Roberts Noble Foundation

2510 Sam Noble Parkway

Ardmore OK 73401, USA

Tel.: 5802246720; Fax: 5802246692

Email: xw...@noble.org

http://www.noble.org/PlantBio/Wang/lab.html

 

[ccp4bb] Postdoctoral Position Available - Structural Cell Biology

[Anand Kolatkar]

Postdoctoral Position - Structural  Cell Biology
The Scripps Research Institute in La Jolla, CA


A Postdoctoral position is available to study the structure and function of 
protein-protein interactions involved in tumor growth. The position requires a 
recent Ph.D. in one of the natural sciences relevant to structural 
biochemistry.  Applicants must be highly motivated and must have demonstrated 
experience (i.e. relevant publications) with 3D protein structure 
determination, protein purification, and crystallization. Our laboratory at The 
Scripps Research Institute in La Jolla, CA is fully equipped for protein 
chemistry and protein crystallography.  In addition, the laboratory has access 
to synchrotron beamlines at SSRL and APS. Apply to Dr. Peter Kuhn, Professor, 
Dept. of Cell Biology (k...@scripps.edumailto:k...@scripps.edu), including 
your CV, statement of research interests, and names of 3 references.

[ccp4bb] Postdoctoral position available in Bethesda, Maryland

[Shuishu Wang]

A postdoctoral position is available immediately at the Department of
Biochemistry, Uniformed Services University to perform structural and
biochemical research on potential drug target proteins from
Mycobacterium tuberculosis.  The candidate will be involved in
recombinant protein expression and purification, biochemical analysis,
and crystal structure determination.  Qualified applicants must have a
recent Ph.D. degree in biochemistry or a related field, with
experience in bacterial protein expression and purification.  Prior
experience in X-ray crystallography is preferred. Uniformed Services
University is located across the street from the National Institute of
Health (NIH) campus in Bethesda, Maryland.  To apply for the position,
please send CV with names and contact information of at least two
referees by e-mail to:

Shuishu Wang
Assistant Professor
Department of Biochemistry
Uniformed Services University
4301 Jones Bridge Road
Bethesda, Maryland 20814
e-mail: shuis...@gmail.com

[ccp4bb] Postdoctoral Position Available

[Richard Baxter]

Dear All,

A position is available for a postdoctoral fellow to pursue structural and 
functional studies of proteins involved in the innate immune response of 
Anopheles gambiae to malaria infection. The successful candidate will be part 
of a new research group combining biophysical techniques such as x-ray 
crystallography and small-angle x-ray scattering with biochemical 
characterization and in vivo validation through collaborative studies. The 
position offers access to in-house x-ray diffraction facilities within the 
Chemistry Dept., numerous local core facilities, synchrotron access at NSLS and 
APS, and expanding opportunities for high-throughput biology at Yale's West 
Campus facility.

Please email a cover letter, resume and contact information for three 
references to richard.bax...@yale.edu, or visit http://baxterlab.sites.yale.edu 
for further contact information. For scientific details see the following 
publications:

Baxter, R.H.G., et. al (2010) A heterodimeric complex of the LRR proteins 
LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae PNAS 
107, 16817-16822.
[doi:10.1073/pnas.1010575107, PMID:20826443]

Fraiture, M. et. al (2009) Two mosquito LRR proteins function as complement 
control factors in the TEP1-mediated killing of Plasmodium Cell Host Microbe 
5, 273-284. 
[doi:10.1016/j.chom.2009.01.005, PMID 19286136]

Baxter, R.H.G. et. al (2007) Structural basis for conserved complement 
factor-like function in the antimalarial protein TEP1 PNAS 104, 11615-11620.
[doi:10.1073/pnas.0704967104, PMID:17606907]

[ccp4bb] Postdoctoral position available at Caltech

[André Hoelz]

The Hoelz laboratory at the California Institute of Technology seeks  
to recruit an outstanding postdoctoral scientist in structural  
biology. Our laboratory focuses on the structure-function  
relationships of multi-protein macromolecular assemblies. Major  
research themes are (1) the nuclear pore complex and evolutionarily- 
related vesicle coats, and (2) histone modifying enzymes and their  
resident multi-protein complexes.


For recent publications, see, for example, Stavropoulos et al., NSMB,  
2006; Hsia et al., CELL, 2007; Melcak et al., SCIENCE, 2007; Debler et  
al., MOL. CELL, 2008; Nagy et al., PNAS, 2009; Hsia et al., PNAS, 2010.


This position requires a recent Ph.D. degree in biochemistry/ 
biophysics with a strong background in x-ray crystallography. The  
successful applicant should be a highly motivated individual with good  
organizational, communication, and interpersonal skills, who is able  
to carry out a structure determination project from protein expression  
to structure refinement.


The laboratory is newly constructed, well-funded, and well-equipped  
with modern biophysical instrumentation and current crystallization  
robotics. Importantly, Caltech has an exceptional infrastructure for  
macromolecular crystallography, including 40 % access to a high  
intensity, completely automated, state-of-the-art crystallography  
beamline equipped with a PILATUS detector at the Stanford Synchrotron  
Radiation Lightsource (SSRL).


The position is available immediately and funded for 2+ years.  
Depending on performance, the position can be extended for up to five  
years.


To apply, please send your CV, a statement of research interests, and  
the names and contact information of at least two references to André  
Hoelz (ho...@caltech.edu).

[ccp4bb] Postdoctoral position available

[Harmer, Nicholas]

A postdoctoral position is available to join the lab of Dr. Nicholas Harmer, at 
the University of Exeter, UK, from 1st October 2010. The position is funded by 
the BBSRC to work on the structure and function of three novel proteins 
involved in the biosynthesis of the capsular polysaccharide of Burkholderia 
pseudomallei, an emerging pathogen and bioterror threat. Diffraction quality 
crystals are already available for one of these proteins. The position will 
involve protein purification, biochemistry and crystallography.

A full advertisement, containing further details of the position and how to 
apply, is available at 
http://admin.exeter.ac.uk/personnel/jobs.php?action=jobareaid=4jid=4847. For 
informal inquiries about the position, please e-mail me  
(n.j.har...@exeter.ac.uk).

Thanks,

Nic Harmer

[ccp4bb] Postdoctoral Position available

[Wolfgang Peti]

One postdoctoral X-ray crystallographer positions is immediately available in 
the group of Wolfgang Peti at Brown University (Providence, Rhode Island, USA).
The person will focus on the characterization of ser/thr protein phosphatase 1 
and its role in cancer and diabetes – an example of the work can be seen @ Nat 
Struct Mol Biol. 2010 Apr;17(4):459-464.
The laboratory has in-house access to a full range of protein production (E. 
coli  BV), as well as biophysical instruments (ITC (VP-ITC + ITC200), CD, DSC, 
fluorescence, light scattering, etc.). Access to in house X-ray crystallography 
(Rigaku) and necessary crystallization equipment (Art Robbins Phoenix, Cryscam 
etc).  Furthermore, the laboratory extensively uses NMR spectroscopy 
(cryo-probe 
equipped Bruker 500  800 NMR spectrometer) and SAXS/WAXS for low resolution 
data analysis. Work ethic in the laboratory is based on collaboration of highly 
motivated individuals within the group and with a large number of 
collaborations 
outside of Brown University. 

Brown University is an Ivy-League University and one of the leading research 
universities in New England (Northeast of US). Providence is a small enough 
city 
to settle quickly, however provides many amenities of large cities. It is also 
one of the most affordable cities in the New England area.

How to apply
Interested candidates, with a background in protein production and X-ray 
crystallography should email a CV and the names of at least two references to 
Wolfgang_Peti at brown.edu. 



Wolfgang Peti
Associate Professor of Medical Science
Associate Professor of Chemistry
Brown University


  

[ccp4bb] Postdoctoral Position Available

[Emmanuel Skordalakes]

A post-doctoral position is immediately available in the Skordalakes laboratory 
at The Wistar Institute, UPENN to study protein nucleic acid assemblies that 
participate in the replication and maintenance of telomeres. We are looking for 
highly motivated candidates that have recently acquired a Ph.D. in biochemistry 
and/or macromolecular crystallography.  Additional information regarding our 
research program can be found at the laboratory's web site(s)


http://www.chem.upenn.edu/chem/research/faculty.php?id=52

http://www.wistar.org/research_facilities/skordalakes/research.htm

Interested applicants should submit their curriculum vitae to Emmanuel 
Skordalakes at sko...@wistar.org


Emmanuel Skordalakes, Ph.D.
Assistant Professor
Gene Expression and Regulation Program

The Wistar Institute
3601 Spruce St
Philadelphia, PA 19104
215-495-6884 Office
215-898-2202 Lab
sko...@wistar.org




-- 
This email was Anti Virus checked by Astaro Security Gateway. 
http://www.astaro.com

[ccp4bb] Postdoctoral Position Available in Structural Biophysics and Protein Engineering in Rockville, Maryland, USA

[Scott Walsh]

Postdoctoral Position Available in Structural Biophysics and Protein 
Engineering in Rockville, Maryland, USA

A NIH funded postdoctoral position is available for a highly motivated 
individual at the Center for the Advanced Research in Biotechnology (CARB) at 
the University of Maryland Biotechnology Institute in Rockville, Maryland, USA. 
 Several research projects are available to study the interleukin-7 signaling 
pathway at the structural and biophysical levels.  Candidates must have a Ph.D. 
degree in biochemistry or a related field, with experience in molecular 
biology, bacterial and insect cell protein expression and purification.  Prior 
experience in structural (X-ray crystallography or NMR spectroscopy) and 
biophysical techniques (circular dichroism, calorimetry, fluorescence, etc.) is 
preferred.  Salary will be commensurate upon experience.  For further 
information or to apply for the positions please send a cover letter, CV, and 
two references to Dr. Scott Walsh (email: wal...@umbi.umd.edu).

[ccp4bb] Postdoctoral position available in Bethesda, Maryland, USA

[Shuishu Wang]

Postdoctoral Position in Protein Crystallography

A postdoctoral position is available immediately at the Department of
Biochemistry, Uniformed Services University of the Health Sciences to
perform structural and biochemical research on potential drug target
proteins from Mycobacterium tuberculosis.  Job duties include protein
expression and purification, biochemical analysis, and crystal
structure determination.  Candidates must have a recent Ph.D. degree
in biochemistry or a related field, with experience in protein
expression and purification and  in protein X-ray crystallography.

Uniformed Services University is located next to the National
Institute of Health (NIH) campus in Bethesda, Maryland, and within a
short Metro ride to Downtown Washington D.C.  The position offers a
competitive salary with generous fringe benefits. To apply for the
position please send CV with names of at least two referees by e-mail
to:

Shuishu Wang
Assistant Professor
Department of Biochemistry
Uniformed Services University
4301 Jones Bridge Road
Bethesda, Maryland 20814

e-mail: shuis...@gmail.com

[ccp4bb] Postdoctoral position available in structural virology

[Frank Lee]

Applications are invited for a postdoctoral position in Dr. Fang Li's
lab at the Department of Pharmacology, University of Minnesota Twin
Cities. Research involves biochemical and structural studies on
proteins that guide invasion and replication of important viral
pathogens.

Strong background in molecular biology and protein
biochemistry is required. Experience in insect cell culture and protein 
crystallography is preferred. Candidates must have completed PhD at
the time of the appointment. Salary commensurates with experience. The
position starts immediately. For more information about Dr. Li's lab,
visit http://www.msi.umn.edu/~lifang/



Interested applicants should send (1) a resume, (2) a one-page summary
of previous research experience, and (3) arrange three letters of
recommendation to Dr. Fang Li via emai: lif...@umn.edu



  

[ccp4bb] Postdoctoral position available

[Hernando Sosa]

A post-doctoral position to study cystoskeletal macromolecular 
assemblies using cryo-electron microscopy is available in the Sosa lab. 
For this position the ideal candidate will  be interested in solving 
problems related to the structure and function of proteins and will be 
willing to learn or develop new experimental techniques as needed for 
the project.  Experience in any one of these areas is desirable: 
Electron Microscopy, Image Analysis, Cellular Light Microscopy, Protein 
Expression and Purification.


In our lab we employ a variety of approaches such as site-directed 
mutagenesis, cryo-electron microscopy and single molecule fluorescence 
microscopy to investigate cystoskeletal motors at the molecular level 
(e. g. see: Tan et al., Structure 16: 1732-9, 2008; Asenjo  Sosa  PNAS 
106: 5657-62, 2009).  We have access to state of the art facilities for 
cryo-em work located at the Albert Einstein College of Medicine and at 
the New York Structural Biology Center that include several cryo-em 
microscopes (Tecnai 200, Tecnai G2 F20, JEOL 1230, JEOL 2100F, JEOL 
3200FSC). Our laboratory is located in the Albert Einstein College of 
medicine in New York City, which offers excellent opportunities for 
scientific interaction within the college and with many other scientific 
institutions in the New York area.  Interested candidates please send a 
letter (or email), CV and reference names to:


Hernando Sosa
Dept. of Physiology and Biophysics
Albert Einstein College of Medicine
1300 Morris Park Av.
Bronx NY 10461
Office: 718-430-3456
Lab: 718-430-3451
FAX: 718-430-8819
Email: hernando.s...@einstein.yu.edu

The Albert Einstein College of Medicine is an equal opportunity employer.

--
---
Hernando Sosa
Dept. of Physiology and Biophysics
Albert Einstein College of Medicine
1300 Morris Park Av.
Bronx NY 10461
phone   (718) 430-3456
FAX (718) 430-8819
email   hernando.s...@einstein.yu.edu
---

[ccp4bb] Postdoctoral Position Available in Structural Biology/Biophysics in Maryland, USA

[Scott Walsh]

A NIH funded postdoctoral position is available at the Center for the Advanced 
Research in 
Biotechnology (CARB) at the University of Maryland Biotechnology Institute in 
Rockville, 
Maryland, USA.  Several research projects are available to study the 
interleukin-7 signaling 
pathway at the structural, biochemical, and biophysical levels.  Candidates 
must have a 
Ph.D. degree in biochemistry or a related field, with experience in molecular 
biology, 
bacterial/insect cell protein expression and purification.  Prior experience in 
structural (X-
ray crystallography or NMR spectroscopy) and biophysical techniques is 
preferred. Salary 
will be commensurate upon experience.  For further information or to apply for 
the position 
please send a cover letter, CV, and two references to Dr. Scott Walsh (email: 
wal...@umbi.umd.edu).

[ccp4bb] Postdoctoral position available in Bethesda, Maryland, USA

[Shuishu Wang]

Postdoctoral Position in Protein Crystallography

A postdoctoral position is available immediately at the Department of
Biochemistry, Uniformed Services University of the Health Sciences to
perform structural and biochemical research on potential drug target
proteins from Mycobacterium tuberculosis.  Job duties include protein
expression and purification, biochemical analysis, and crystal
structure determination.  Candidates must have a recent Ph.D. degree
in biochemistry or a related field, with experience in protein
expression and purification and  in protein X-ray crystallography.
Uniformed Services University is located across the street from the
National Institute of Health (NIH) campus in Bethesda, Maryland.  The
position offers a competitive salary with generous fringe benefits.
Interested persons please send CV with names of at least two referees
by e-mail to:

Shuishu Wang
Assistant Professor
Department of Biochemistry
Uniformed Services University
4301 Jones Bridge Road
Bethesda, Maryland 20814

e-mail: shuis...@gmail.com

[ccp4bb] Postdoctoral position available: Protein recognition of anesthetics

[Patrick Loll]

A postdoctoral position will be available Fall 2009 in Philadelphia,  
PA, USA. The successful candidate will join a collaborative research  
effort between the Eckenhoff laboratory at the University of  
Pennsylvania and the Loll laboratory at the Drexel University College  
of Medicine. This collaboration is aimed at studying the structural  
basis of anesthetic recognition by proteins (see for example  FASEB  
J.,19: 567-576 (2005)  ACS Chem. Biol. 1: 377-384 (2006)). Ideally,  
applicants will have experience in macromolecular crystallography, as  
well as one or more of the following areas: preparative protein  
biochemistry, experimental assessment of ligand binding by proteins,  
and/or the biophysical analysis of proteins.


 The Departments of Anesthesiology and Critical Care at Penn and  
Biochemistry and Molecular Biology at Drexel feature excellent  
resources, including instrumentation for fluorescence and circular  
dichroism spectroscopy, calorimetry, and mass spectrometry, and a  
complete X-ray diffraction facility furnished with state-of-the-art  
equipment.
The collaborating laboratories are conveniently located in downtown  
Philadelphia, and offer collegial and stimulating environments with  
many opportunities for collaboration.  Philadelphia is a vibrant and  
eminently livable city with a large biomedical research community.   
The city offers outstanding cultural and recreational activities, and  
is close to New York City and Washington DC, as well as Atlantic  
Ocean beaches and the Pocono mountains.


Please send a CV and a cover letter explaining your research  
interests to Dr. Roderic Eckenhoff: roderic.eckenh...@uphs.upenn.edu.



 
---

Patrick J. Loll, Ph. D. 
Professor of Biochemistry  Molecular Biology
Director, Biochemistry Graduate Program
Drexel University College of Medicine
Room 10-102 New College Building
245 N. 15th St., Mailstop 497
Philadelphia, PA  19102-1192  USA

(215) 762-7706
pat.l...@drexelmed.edu

[ccp4bb] Postdoctoral position available

[Stewart Turley]

Postdoctoral Position available in the Laboratory of Wim Hol
Department of Biochemistry, School of Medicine,
University of Washington, Seattle, USA

Structural Biology and structure-based inhibitor design of the invasion
machinery of the malaria parasite.



JOB DESCRIPTION:

This project aims to unravel the structure of the invasion machinery of 
the
malaria parasite and to design inhibitors to interfere with the proper
functioning of the machinery. Such inhibitors might be the foundation for new
anti-malarials.

The malaria parasite invades two types of cells when in the human host:
hepatocytes and erythrocytes. This invasion is a fascinating and very complex
process, but some features are shared in the invasion of these two different
cell types. These include aldolase (yes, the glycolytic enzyme is moonlighting
here...) interacting with an actin filament, a specific myosin motor interacting
with the actin, a myosin-tail interacting protein (MTIP), and a number of
so-called GAP proteins. We have elucidated several structures of interacting
proteins in this system. There are also exciting invasion-blocking compounds
which we try to co-crystallize with their target protein.

The aims for the project in the next few years are; (i) to obtain 
additional
structural information about additional proteins and multi-protein complexes of
the machinery; and, (ii)
to assist in structure-based design of invasion inhibitors.

The project is an interdisciplinary collaboration with molecular 
modeling,
chemical synthesis, parasitolology and biochemical groups, in the Biomolecular
Structure Center of the University of Washington, Seattle, and Drexel
University, Philadelphia.

The successful candidate will have the opportunity to: (i) carry out 
protein
expression and protein chemistry studies to obtain insight into protein-protein
interactions involving the invasion machinery of the malaria parasite; (ii)
determine high resolution crystal structures of individual proteins as well as
multi-protein sub-complexes of the machinery; (iii) solve crystal structures of
invasion proteins in complex with small molecule inhibitors. There will also be
opportunities to carry out biophysical binding assays. Several expression
systems are already available for preparing soluble proteins from the invasion
machinery.

For further information regarding our studies on the invasion machinery 
see:

Bosch, J., Turley, S., Daly, T. M., Bogh, S. M., Villasimil, M. L., Roach, C.,
Zhou, N., Morrisey, J. M., Vaidya, A. B., Bergman, L. W.  Hol, W. G. J. (2006).
Structure of the Plasmodium MTIP-MyoA complex, a key component of the malaria
parasite invasion motor. Proc. Natl. Acad. Sci. USA 103, 4852-4857.

Bosch, J., Buscaglia, C. A., Krumm, B. E., Ingason, B., Lucas, R., Roach, C.,
Cardozo, T., Nussenzweig, V.  Hol, W. G. (2007). Aldolase provides an unusual
binding site for TRAP in the invasion machinery of the malaria parasite. Proc.
Natl. Acad. Sci. USA, 104, 7015-8020.
Bosch, J., Turley, S., Roach, C., Daly, T. M., Bergman, L. W.  Hol, W. G.
(2007) The Closed MTIP-MyosinA-tail Complex from the Malaria Parasite Invasion
Machinery. J Mol Biol. 372, 77-88.

And for information regarding the research in our lab see the websites:
http://www.bmsc.washington.edu/WimHol/
http://depts.washington.edu/biowww/faculty/hol.html

JOB REQUIREMENTS:  - Experience with:
- protein expression and purification methods
- characterization of purified soluble proteins
- protein crystallization
- At least three years of experience with protein structure determination
methods, including:
X-ray diffraction data collection and data processing; experimental and
molecular replacement phasing methods; density modification; crystallographic
refinement.
- Excellent interpersonal skills to function optimally in the malaria invasion
project team and to cooperate with collaborators in other groups and
institutions.


Experience in one or more of the following fields would be a plus:
- Molecular biology for protein overexpression
- Purification and characterization of multi-protein complexes
- Biophysical binding assays
- Molecular modeling for inhibitor design.


START DATE: Immediately

INSTITUTION:Department of Biochemistry
Biomolecular Structure Center
School of Medicine
Box 357742
University of Washington
Seattle, WA, 98195  USA

Please send your CV, including a description of your experience, a list of
publications, and names and email addresses of three references able to assess
your scientific experience and capabilities to: wg...@u.washington.edu

[ccp4bb] postdoctoral position available in Cambridge

[Matthew Higgins]

Postdoctoral Vacancy

Research Associate

A Wellcome Trust funded postdoctoral position is available to work with Dr 
Matt Higgins in the Department of Biochemistry, Cambridge University on 
the structural biology and biochemistry of cell surface proteins involved 
in severe and cerebral malaria. Experience in protein expression, 
purification and crystallography would be a major asset for this position.


Applications are welcomed from talented scientists, who hold (or will be 
shortly be receiving) a PhD in a relevant biological discipline.


Applications should include a covering letter describing relevant research 
experience to date, a CV, PD18 form with parts 1 and 3 completed and the 
names and addresses of two referees. These should be sent quoting the 
reference by email by to j...@bioc.cam.ac.uk or post to The Principal 
Assistant, Department of Biochemistry, Building O, Downing Site, Tennis 
Court Road, Cambridge, UK, CB2 1QW.


Informal enquiries can be made to Matt Higgins on mk...@cam.ac.uk

Salary: 27,183-35,469 pa
Limit of Tenure 36 months in the first instance

Quote Reference: PH04897  Closing Date: 3 April 2009

[ccp4bb] Postdoctoral position available

[Howard S. Young]

Applications are invited for a postdoctoral position to work on the  
structure determination of membrane transport proteins critical in  
cardiovascular function. The transporters we study have been linked to  
human disorders such as cardiomyopathy, ischemia-reperfusion injury,  
and various cancers. Our aim is to understand the molecular regulation  
of the transporters with the goal of rational design of novel  
inhibitors and activators. We seek an enthusiastic candidate  
experienced in macromolecular x-ray or electron crystallography.  
Experience with membrane protein biochemistry would be an asset. In  
addition, the successful candidate should be well-versed in one or  
more of the following areas: molecular biology, protein purification,  
crystallization, and membrane protein and lipid biochemistry.


This is an opportunity to join a lab experienced in the expression and  
crystallization of membrane proteins [See Biophysical Journal (2006)  
90:4213-23, JBC (2007) 282:9748-57, and JBC (2008) 283:4145-54]. Our  
department provides interaction with numerous structural biologists.  
In addition, the University of Alberta Membrane Protein Research Group  
provides a dedicated forum for membrane protein research that includes  
14 research laboratories (http://www.mprg.med.ualberta.ca/index.php ).


The University of Alberta, located in Edmonton, Alberta (Canada), is  
home to a large and interactive community of biomedical scientists  
http://www.med.ualberta.ca/; support and facilities for structural  
biology are excellent. A state-of-the-art facility is available for  
electron microscopy at the National Institute for Nanotechnology,  
University of Alberta  
(http://nint-innt.nrc-cnrc.gc.ca/research/micro/index_e.html), and a  
newly commissioned synchrotron facility is located a short drive away.  
Edmonton, having a population of approximately 1 million, offers a  
cosmopolitan environment with world class performing arts, sports,  
culinary and recreational opportunities.  In addition, the city’s  
proximity to the Rocky Mountains including the towns of Jasper and  
Banff is an additional bonus.


Salary is commensurate with training and experience at the CIHR  
standard rates. A medical and dental benefit package is included with  
salary. Funding is also available through several competitive funding  
agencies, including CIHR (http://www.cihr.ca/ ) and Alberta Heritage  
Foundation for Medical Research (http://www.ahfmr.ab.ca/ ). The  
University of Alberta hires on the basis of merit. We are committed to  
the principle of equity in employment. We welcome diversity and  
encourage applications from all qualified women and men, including  
persons with disabilities, members of visible minorities, and  
Aboriginal persons. The records arising from this competition will be  
managed in accordance with provisions of the Alberta Freedom of  
Information and Protection of Privacy Act (FOIPP).


Please direct CV's or inquiries to the following email address:  
hyo...@ualberta.ca.


Howard S. Young
Associate Professor
Department of Biochemistry
University of Alberta
Medical Science Bldg, room 327
Edmonton, AB, Canada
T6G 2H7

National Institute for Nanotechnology,
National Research Council of Canada

Membrane Protein Research Group
(http://www.mprg.med.ualberta.ca/group-members.php)

[ccp4bb] Postdoctoral position available at The Institute of Cancer Research

[Rob vanMontfort]

The Institute of Cancer Research



Section of Structural Biology / Section of Cancer Therapeutics



		Post-doctoral Training Fellow Structural  
elucidation of phosphatase cancer target



(Chelsea, London  Sutton, Surrey)



The Institute of Cancer Research is one of the world's leading cancer  
research organisations and is internationally renowned for the  
quality of its science.  Our mission is the relief of human suffering  
by pursuing excellence in the fight against cancer.




An Institute of Cancer Research-funded Postdoctoral position is  
available immediately in Dr. Rob van Montfort’s Structure-Based Drug  
Design group. The successful candidate will work on the structure  
elucidation of a phosphatase implicated in cancer and be involved in  
subsequent structural studies to investigate the protein-ligand  
interactions of small molecule inhibitors bound to the protein. The  
post-doc will be expected to interact closely with biologists,  
computational chemists and medicinal chemists throughout The  
Institute and will work across two sites in Chelsea, London and  
Sutton, Surrey.




The Structure-Based Drug Design group is a joint initiative between  
the Section of Structural Biology and the Section of Cancer  
Therapeutics at the ICR.  The Institute is exceptionally well  
equipped for all aspects of drug discovery, with state-of-the-art  
laboratories for molecular biology, recombinant expression in  
bacterial and eukaryotic systems, biochemistry, X-ray crystallography  
and medicinal chemistry.




Applicants must have a PhD in a biological or physical science, and  
experience in macromolecular crystallography / crystallisation (to  
include protein biochemistry, protein crystallisation,  protein  
crystallography). Experience in molecular biology, protein  
purification, and/or Structure-Based Drug design will be an advantage.




The starting salary for the position will be in the range £29,256 to  
£31,551 p.a. inclusive (based on previous post-doctoral experience)  
and the post is offered initially on a fixed term contract of up to  
18 months.  Informal enquiries to [EMAIL PROTECTED] Please  
DO NOT send your application to Dr. van Montfort; CVs must be  
submitted in line with the instructions below.




For further particulars and details of how to apply, please visit our  
website at www.icr.ac.uk.  Alternatively you may call our 24 hour  
recruitment line on 020 7153 5475 quoting reference number C183.




Closing date:  Friday 31 October 2008

Interviews to be held:Week commencing 17 November 2008


Dr. Rob van Montfort
Team Leader Structure-Based Drug Design
Sections of Cancer Therapeutics and Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG
UK

Tel:
+44-(0)20-8722-4364 (Sutton)
+44-(0)20-7153-5142 (Chelsea)
Email: [EMAIL PROTECTED]


The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company 
Limited by Guarantee, Registered in England under Company No. 534147 with its 
Registered Office at 123 Old Brompton Road, London SW7 3RP.

This e-mail message is confidential and for use by the addressee only.  If the 
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computer and network.

[ccp4bb] Postdoctoral Position Available

[Emmanuel Skordalakes]

Postdoctoral Position in Macromolecular Crystallography at The Wistar  
Institute


A post-doctoral position is immediately available in the laboratory  
of E. Skordalakes, Department of Gene Expression and Regulation at  
The Wistar Institute to study protein nucleic acid assemblies that  
participate in the replication and maintenance of telomeres.


We are looking for a highly motivated candidate that has recently  
acquired a Ph.D. in biochemistry and/or macromolecular  
crystallography. Experience or interest in drug design would be a  
plus. Interested candidates should send their CV and contact  
information of three references to E. Skordalakes at [EMAIL PROTECTED]



Emmanuel Skordalakes, Ph.D.
Assistant Professor
Gene Expression and Regulation Program

The Wistar Institute
3601 Spruce St
Philadelphia, PA 19104
215-495-6884 Office
215-898-2202 Lab
[EMAIL PROTECTED]