Ben:   MT: Venter has changed everything
today - including the paradigms that govern both science and AI..
Ben:  Lets not overblow things -- please note that Venter's team has not yet
synthesized an artificial organism.

Here's why I think Venter's so important - to quote a post of mine to an evo-psych group [I also recommend here BTW Dennis Noble's "The Music of Life" - re "genetic keyboard"]:

"Over and above its immediate, technological significance for Artificial Life, I see this as the end of an era in science. I think the defining scientific paradigm of the last 50 years - the genetic code, or program, and with it the idea that we are determined by our genes - is now dead (or in its death throes). [I would define genetic determinism BTW as ALLOWING for, and in no way excluding, environmental influences].

I think the replacement for that paradigm is now clear, even if it hasn't been exactly defined, and that is - the genetic keyboard. That might not be immediately obvious. But if you think about it, what has happened - Craig Venter & co creating a new genome - is an example of the genetic keyboard playing on itself, i.e. one genome [Craig Venter] has played with another genome and will eventually and inevitably play with itself. Clearly it is in the nature of the genome to recreate itself - and not just to execute a program. (And indeed, had the computational paradigm been properly thought through, it would have been noted that it is in the nature of programs - as actually produced and existing on computers - that they are NOT stable entities but are normally, and more or less demand to be, endlessly reprogrammed - by the use, as it happens, of a keyboard).

Craig Venter has disavowed genetic determinism: "There are two fallacies to be avoided," Dr Venter's team write in the journal Science. "Determinism, the idea that all characteristics of a person are 'hard-wired' by the genome; and reductionism, that now the human sequence is completely known, it is just a matter of time before our understanding of gene functions and interactions will provide a complete causal description of human variability."

More significantly for EP, Venter has also disavowed natural selection:

"The key problem is that far from being the simple computer code we once thought it was, DNA is fabulously complex. When I last interviewed Venter a decade ago, he said our DNA was too complex to be designed by man and probably even too complex for natural selection. The problem has worsened: "With the publication now of the full genome, it's clearly more complicated than ever.

"All our data from the environment and other places is telling us there are different components to our personalities. Certainly step by step everything's just a point mutation and things change. But I don't think that can explain everything. People have this simplistic view of Darwinian evolution as random point mutations in the genetic code followed by natural selection. No, I don't think that would have got us out of our genome."

http://www.timesonline.co.uk/tol/news/uk/science/article2752196.ece

P.S. I would acknowledge that there is still philosophical/scientific work to be done - the case for the changeover of paradigms has been not fully made. But it is now inevitable.

P.P.S. The full new paradigm is something like - "the self-driving/ self-conducting machine" - it is actually the self that is the rest of the body and brain, that interactively plays upon, and is played by, the genome, (rather than the genome literally playing upon itself). And just as science generally has left the self out of its paradigms, so cog sci has left the indispensible human programmer/operator out of its computational paradigms.

To bring in the Gudrun discussion, you could say that science is about to tell us that what you - your self - do with your body (as distinct from how it works) is not science but art (and, let's not forget, technology). The idea that you are deterministically destined to play only one kind of music on your keyboard is quite mad - a keyboard, by definition, like your body and brain, offers you an infinite range of possibilities.



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